A team led
by Young - sup Yoon, MD, PhD developed a new method for generating
endothelial cells, which
make up the lining of blood vessels, from human induced pluripotent stem
cells..
Josin researchers
made two major findings: They identified the mechanisms
by which GLP - 1 can induce protective actions on the glomerular (renal)
endothelial cells by inhibiting the signaling pathway of Ang II and its pro-inflammatory effect; and demonstrated a dual signaling mechanism
by which hyperglycemia, via PKCβ activation, can increase Ang II action and inhibit GLP - 1's protective effects
by reducing the expression of GLP - 1 receptors in the glomerular
endothelial cells.