Technological advances have
made genomic approaches critical for understanding basic biological processes, so that genomic research now impacts all areas of life science research.
Not exact matches
The U.S. National Institutes of Health (NIH) has
made major investments in network
approaches in many areas, including cancer biology, cardiovascular and metabolic diseases, neurophysiology, and human genetics and
genomics.
In theory, insights into the genetic underpinnings of cancer,
made possible through
genomic sequencing, will allow people with even the hardest - to - treat diagnoses to benefit from individualized treatment
approaches.
A more useful
approach, he says, would be to find a way to
make genomic data public without allowing individuals to be identified.
Without this
approach, the results of
genomic sequencing would have been swamped with DNA from normal cells,
making it difficult to detect cancer - linked DNA errors, Papp says.
Glass and his Venter Institute colleagues are now using synthetic biology and synthetic
genomics approaches developed at the JCVI to create cells and organelles with redesigned genomes to
make microbes that can produce biofuels, pharmaceuticals, and industrially valuable molecules.
Not so long ago, the advent of powerful
genomic tools and genetic engineering techniques
made it seem that studies involving mice engineered to carry human disease genes would be the best
approach for exploring human disorders, superior to looking at cells isolated in a laboratory.
The current explosion of
genomic sequence
makes this an exciting time to study insect immunity, and although further work will be necessary to extend the analyses we present here, the combination of genome and transcriptome sequencing provides a scalable
approach to characterize the inducible immune response across a broad taxonomic range.