BUILDING artificial tissue could become child's play, if Lego - like blocks
made of human cells can be assembled into working organs.
Q2 «Fetus is
made of human cells and has a independent heart (however primitive)?
Being
made of human cells irrelevant, as you can find Jesse James» human cells, and he isn't alive.
Not exact matches
While we thrive thanks to lightning speed Internet connections,
cell phones that are smarter than the average
human being and other neat gadgets that
make our lives feel and seem easier, we are exhausting a number
of non-renewable resources.
Prior to the development
of a fully functioning nervous system, and the activation
of said system, a
human embryo is «alive» in the same sense a tumor is «alive»: the individual
cells that
make it up are alive, but there is no higher - level functionality.
Proponents
of human cloning assert that this is the only method
of producing pluripotent stem
cells with the same genetic
make - up as adult patients.
This depends upon there being a brain, an arrangement
of cells in a particular part
of the body which by reason
of its peculiar coordination
makes the given routing able to «know» in a distinctively
human manner — quite different from, although certainly continuous with, the sort
of «knowing» that is possible for the higher grades
of animal life.
They include going after the damage to
cells done by free radicals,
making use
of hormone therapy, or caloric restrictions, or vitamin supplements, or, most dramatically, healthy gene selection through pre-implantation genetic diagnosis and even repairing the entire
human genome.
------------- And if 90 %
of dust particles are
made up
of human skin
cells, then I think there's a naked man living under my bed... And he's HAIRY!
Some people would
make an exception
of one
cell, the fertilized
human ovum.
Modern psychosomatic medicine has
made some progress in analyzing along these lines; for example, it seems quite possible that the emotional tone
of my soul may directly alter the patterns
of physical feeling in my stomach.4 Still, we should not suppose too quickly that the aims
of a
human personality have any very effective direct influence on the molecules
of body
cells, other than those in the brain.
Specifically, when capsaicin frequently binds to receptors within the
human central nervous system's TRPV1 channel (the sensory receptor system for pain and heat detection), these receptors deplete and this depletion results in a whole host
of benefits for the central nervous system at large, including terminating cancer
cells, increasing the metabolic rate and digestive efficiency, increasing circulatory blood flow, and combatting inflammation, and
making you feel better about the world.
This approach revealed a highly sensitive portrait
of the genes being expressed in
human milk -
making cells.
For a long time, insulin was not thought to play a direct role in regulating the milk -
making cells of the
human breast, because insulin is not needed for these
cells to take in sugars, such as glucose.
By the 4 - 8
cell stage
of life,
human embryos have to «turn on» their own genes and start
making their own proteins.
Visually, she is filming and analyzing time - lapse images
of human embryos in the incubator and has been able to correlate various parameters
of how
cells divide with the probability that the embryos will
make it to a full blastocyst stage by day 5 - 6
of culture.
Frankenbunnies Embryos
made by Chinese researchers who fused
human skin
cells with rabbit eggs, hoping to create a source
of stem
cells.
Martin Fussenegger
of the Swiss Federal Institute
of Technology in Zurich and his colleagues
made this implant by genetically altering
human skin
cells so that they would become darker in colour when exposed to rising calcium levels.
To
make the HSCs, the Harvard group used
human skin
cells to create induced pluripotent stem
cells (iPSCs), adult
cells researchers genetically reprogram to an embryonic - stem -
cell state, where they can grow into any kind
of cell.
Introducing
human prostate cancer
cell lines into mice, Wu and his colleagues saw a particular enzyme called MAOA activate a cascade
of signals that
made it easier for tumor
cells to invade and grow in bone.
That success represents a dilemma for neuroscience, said bioethicist Hank Greely
of Stanford University: «When you
make a chimera with
human cells in its brain, the closer the resulting brain is to
human» in structure and function and «the greater the ethical and public concern.»
If true, this would be the first method to complete the final steps in
making human sperm, although other labs have managed to push
cells through some
of the earlier stages.
Hammer and colleagues Dennis Discher and Frank Bates attempted to scale up this process to
make vesicles more than 10 micrometers in diameter — the size
of human cells.
A new type
of human stem
cell, never seen in nature, should be better at
making replacement organs than existing stem
cells
Trials
of cells made from
human embryonic stem
cells are also poised to begin in people with type 1 diabetes and heart failure, the first time embryonic stem
cells have been used in the treatment
of major lethal diseases.
The man responsible for one
of the original sequences
of the
human genome as well as the team that brought you the first living
cell running on
human -
made DNA now hopes to harness algae to
make everything humanity needs.
In the study, the researchers loaded a hydrogel — a half - inch disc
made of a biodegradable sugar naturally found in the
human body — with drugs that activate dendritic
cells.
Yet, whereas the
cells of bacteria and other microbes are small and simple, all visible life, including us
humans, is generally
made up
of large and complex
cell types.
«Today's findings exemplify the many advances we've
made in using CRISPR - Cas9 and
human induced pluripotent stem
cell technologies and the amazing discoveries that have resulted,» said Hideyuki Okano, MD, PhD,
of the Keio University School
of Medicine in Tokyo, Japan.
Scientists have long experimented with organs - on - chips: tiny representations
of human organs, such as lungs, hearts and intestines,
made from
cells embedded on plastic about the size
of a computer memory stick.
But the factor that may
make the discovery very significant is that umbilical cord blood can be saved, stored and multiplied without any
of the ethical dilemmas facing embryonic stem
cell use, which are derived from
human fetuses.
Nor do they need to be nourished from underneath by «feeder layers»
of animal
cells which have been shown to contaminate
human cells grown,
making them unsuitable for use in medical treatments.
John Glass, a senior microbiologist in the synthetic biology group at the J. Craig Venter Institute in Rockville, Maryland, puts it this way: If you can imagine a set
of genes that will program a
cell to do something — anything — then you can
make them «at a reasonable cost and test your hypothesis... so it will be possible to attempt to design organisms that have extraordinary properties to solve
human needs.»
The patch is
made of eye
cells made from
human embryonic stem
cells, and it has been designed for treating the «dry» form
of macular degeneration, which accounts for 90 per cent
of all cases, and affects 1.7 million people in the US.
The same observations were
made in organoids (artificially grown masses
of cells that resemble an organ) created from unique basal progenitor
cells that were isolated from the gastroesophageal junction in mice and
humans.
The Duke researchers who
made this discovery say it may help explain how a relatively small number
of genes can create the dazzling array
of different
cell types found in
human brains and the nervous systems in other animals.
Another interesting aspect to the work is that it demonstrates the possibility
of adding new machinery to
human cells to enable them to
make therapeutic agents in response to disease signals.»
«One
of the broader goals
of our research is to
make regenerative treatments more accessible and clinically relevant by developing easy, efficient and cost - effective ways to engineer
human cells and tissues,» said Shyni Varghese, a bioengineering professor at UC San Diego and senior author
of the study.
«We have identified the molecular mechanisms by which the Tat protein
made by HIV interacts with the host
cell to activate or repress several hundred
human genes,» said Dr. Iván D'Orso, Assistant Professor
of Microbiology at UT Southwestern and senior author
of the study.
Geron, the biotech wunderkind, last
made big news in November 1998 when scientists they funded — James A. Thomson
of the University
of Wisconsin and John D. Gearhart
of Johns Hopkins — independently isolated two sorts
of so - called
human pluripotent stem
cells.
His laboratory discovered that some
of the same RNA that is inside
human cells are also present in saliva and can be used to detect diseases — a surprising finding, he said, because enzymes in saliva can degrade RNA,
making the mouth «a hostile environment.»
In
humans, the goal
of SCNT is «nonreproductive cloning» —
making embryos, then removing stem
cells from the embryo and cultivating them to grow into tissues that could cure diseases, replace organs and heal injuries.
Twelve people with Stargardt's macular dystrophy will be treated with retinal
cells made from
human embryonic stem
cells (hESCs) in the hope
of improving, or at least halting loss
of sight.
Most animals, including
humans, have two copies
of their genome — the full set
of instructions needed to
make every
cell, tissue, and organ in the body.
Physician David Nathan, director
of the diabetes center at Massachusetts General Hospital in Boston, notes in an email message that «what is ironic here is that [free radicals are] generally thought to be bad in
human diabetes,» because they lead to dysfunction in the
cells that
make insulin and vascular complications.
In studies with
human fibroblasts that
make up connective tissue, Boger's team tested whether NOD1 activity could affect CMV replication in cultures
of cells grown in the lab.
«It's taken years
of trial and error,
making educated guesses and taking baby steps to finally produce functioning
human muscle from pluripotent stem
cells,» said Lingjun Rao, a postdoctoral researcher in Bursac's laboratory and first author
of the study.
An initial library
of 15 biodegradable particle formulations was tested for their ability to carry siRNAs into
human glioblastoma
cells that were genetically engineered to
make green fluorescent protein (GFP).
The report, from a committee
made up
of 11 members
of Parliament, also recommends legalizing research involving embryos
of chimeras and hybrids, which includes
cells created by fusing
human and animal nuclei.
The results obtained by Afsaneh Gaillard's team and that Pierre Vanderhaeghen at the Institute
of Interdisciplinary Research in
Human and Molecular Biology show, for the first time, using mice, that pluripotent stem
cells differentiated into cortical neurons
make it possible to reestablish damaged adult cortical circuits, both neuroanatomically and functionally.