Not exact matches
By increasing the speed and accuracy for NGS data analysis like whole
genome sequencing (WGS), our computing platform
makes it easier to discover links between DNA
sequence variations and
human disease.»
The man responsible for one of the original
sequences of the
human genome as well as the team that brought you the first living cell running on
human -
made DNA now hopes to harness algae to
make everything humanity needs.
Their work has
made it increasingly clear that for all the popular attention devoted to
genome -
sequencing projects, the epigenome is just as critical as DNA to the healthy development of organisms,
humans included.
Experiments on it have illustrated what genes are
made of, confirmed Darwinian evolution, and helped
sequence the
human genome.
These retroviral gene
sequences make up about 8 per cent of the
human genome, and are part of what is called non-coding DNA because they don't contain genetic instructions to
make proteins.
The
sequencing of the
human genome has
made it possible: nowadays scientists can discover potential disorders for which there are no known patients.
The rationale for
sequencing and exploring the
human genome — to revolutionize the finding of new drugs, diagnostics and vaccines, and to tailor treatments to the genetic
make - up of individuals — is the same today.
Wheat and its wild ancestors have
genomes much larger than
humans, which
makes sequencing difficult.
His first book related the story of how he led a private effort that raced a government - funded consortium to decipher the DNA
sequence that
makes up the
human genome.
«The Neandertal
genome sequence just by itself will not tell us what
makes humans special, it will always be in conjunction with other work that really addresses the biology of a specific change,» he says.
Sequencing the
human genome cost roughly $ 500 million, and essentially all that scientists had to show for the money was a long string of letters that
make up
human DNA.
That map was constructed before the
human genome was
sequenced, which
made it hard to place genetic markers in the right order.
A New World monkey joins a growing list of primate species with
sequenced genomes, improving genomicists» ability to tell what genes
make primates — and
humans — unique.
Since the
sequencing of the
human genome was completed in 2003, researchers have been trying to figure out which parts of the
genome made some people more likely to develop certain diseases.
How the
Human Genome Project will
sequence the 3 billion pairs of chemical bases that
make up our DNA strands
Ever since researchers
sequenced the chimp
genome in 2005, they have known that
humans share about 99 % of our DNA with chimpanzees,
making them our closest living relatives.
Whereas the first
sequencing of the 3.2 billion base pairs of DNA that
make up the
human genome took many years and cost tens of millions of dollars, today your
genome can be
sequenced and digitized in minutes and at the cost of only a few hundred dollars.
These require grantees to
make public on a weekly basis raw information taken directly from
sequencing machines — more detailed data than were required from
human genome sequencers.
He says HGS was getting «diminishing returns» from its investment in TIGR since Venter had steered his outfit into
sequencing organisms of little medical importance, and into
human genome sequencing, also of limited value for a company like HGS that is interested in genes as drug targets (not untranslated DNA that
makes up most of the
genome).
The
sequencing of the
human genome (ScienceNOW, 14 April 2003:) gave scientists major new insights into what
makes us
human: Although we share more than 98 % of our genetic code with the chimpanzee, natural selection has turned us into a very different animal than the chimps, from whom our hominid ancestors split evolutionarily some 6 million years ago (ScienceNOW, 31 August).
«We are confident that NHGRI grantees will continue to
make major breakthroughs in the development of technologies that will eventually lead to the ability to
sequence a
human genome for $ 1,000 or less,» NHGRI Director Eric D. Green said.
In the post-genomic era, we are witnessing significant advances in the functional decipherment of the
human genome sequence that have been
made possible by new technological developments in the field of genomic medicine.
This expertise is coming into its own in the internationally collaborative 1000
Genomes Project: «While the
genome sequence is what
makes us
human, it's the differences in the
genome sequences between all of us that are really the interesting part,» says Paul.
The first ancient
human genome from Africa to be
sequenced has revealed that a wave of migration back into Africa from Western Eurasia around 3,000 years ago affected the genetic
make - up of populations across East Africa.
It was widely held that
sequencing the
human genome would uncover all that was needed to understand how the
human body works, what
makes us
human, and why we differ from each other.
She has
made an important contribution to several international research consortia in
human genomics, including the Genotype Tissue Expression (GTEx) Project, the 1000
Genomes Project and led the RNA -
sequencing work of the Geuvadis Consortium.
Over 100,000
genomes of individual
humans (based on various estimates) have been
sequenced allowing for deep insights into what
makes individuals and families unique and what causes disease in each of us.
Most of that is by design: the 1,000
Genomes Project generated and
made available
sequence data for more than 1,000 individuals in an effort to further characterize
human genetic variation.
Biology went that route with the launch of the
Human Genome Project, the international effort to determine the sequence of 6 billion molecular «letters» that make up human
Human Genome Project, the international effort to determine the
sequence of 6 billion molecular «letters» that
make up
humanhuman DNA.
And the dramatic decrease in the costs of
genome sequencing, spurred on by the Human Genome Project, makes production of this data a bargain by any estimate.&
genome sequencing, spurred on by the
Human Genome Project, makes production of this data a bargain by any estimate.&
Genome Project,
makes production of this data a bargain by any estimate.»
One
sequence, called Alu, has copied itself a million times and
makes up some 10 percent of the
human genome.
We have the capability of
sequencing genomes, the part of your cells that
make a
human a
human or a Roma tomato a Roma tomato.