Not exact matches
The ability of these children to maintain an intact
immune system in the face of ongoing viral replication and in the absence of antiretroviral therapy can provide us with new insights into hitherto unknown
defense mechanisms, which could eventually benefit other HIV patients,» says Professor Oliver T. Keppler, Chair of Virology at the Pettenkofer Institute, and former head of the German Reference Center for Retroviruses in Frankfurt am
Main.
In people with SCID, the stem cells that would become T cells — one of the
immune system's
main lines of
defense against infection — lack a crucial protein receptor that tells them to start reproducing.
The
main mechanism includes phagocytosis of macrophages which play a critical role in nonspecific
defense (innate immunity) and, moreover; they have a role as antigen presenters which also help initiate specific
defense mechanisms (adaptive immunity) by recruiting other
immune cells such as lymphocytes.