It is no longer debated that the chromatin structure is crucial to
maintain cell identity, but the how remains.
DNA binding proteins called transcription factors are required for
maintaining cell identity.
Not exact matches
A very interesting finding was that this mechanism is important for
maintaining the
identity of the
cells.
At each division, our DNA code and a whole machinery of supporting components has to be faithfully duplicated to
maintain the
cell's memory of its own
identity.
In the normal
cells, PDX1
maintains the
cells»
identity as pancreas
cells and epithelial
cells.
By controlling the transport of histones to our DNA, TLK and Asf1 ensure that the chromatin architecture and its information are copied correctly during
cell division, so that
cell identity is
maintained,» explains Ilnaz Klimovskaia.
This information is crucial to understand how
cells maintain their
identity and protect their genome, which is essential to avoid cancer development,» says associate professor Anja Groth, who has been heading the research team.
The team has also found that high density lipoproteins (HDL)-- more commonly known as «good cholesterol» — counteract this process, helping the protective immune
cells maintain their
identity and keep arteries clear.
«This, in turn, activates another group of proteins, called ETS transcription factors, and it is this signaling relay — from Vegf to MAPKs to ETS factors — that turns on an
maintains Dll4 activity, helping the arterial
cells grow and gain their cellular
identity over time.»
Barton Lab discovers how stem
cells maintain identity (12/1/16) The Barton lab is leading the way in understanding the functions of non-coding RNAs, especially at the convergence of stem -
cell biology and epigenetics.