Sentences with phrase «maintaining robust activity»
«We hypothesized that for a given pair of targets that differ by a single point mutation, a set of mismatches could be identified in the guide RNA that would eliminate Cas9's activity on the normal sequence while maintaining robust activity on the one with a deleterious point mutation.
https://www.sciencedaily.com/ Not exact matches
They identified enhanced - specificity variants (eSpCas9) that display reduced off - target cleavage while maintaining robust on - target activity