Sentences with phrase «maintains telomere»

The SMC5 / 6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere - binding proteins.

She also discovered telomerase, an enzyme that repairs and maintains telomere ends.

In another clue that cancer cells persist because they maintain their telomeres, those cells that started out with longer telomeres in the experiment lived longer than those with shorter telomeres.

Such a lag time, says Hahn, could allow cancer cells to develop resistance to a drug by finding some other way to maintain their telomeres.

Here it is shown that most survivors have circularized all of their chromosomes, whereas a smaller number maintain their telomeres presumably through recombination.

Blasco is best known for her research on the enzymes that maintain telomeres — repetitive DNA sequences capping the chromosomes — and their role in cancer and aging.

As a safeguard, in cells such as egg, sperm, and stem cells, an enzyme called telomerase is responsible for preventing this wear and tear by maintaining telomere length.

Sierra Sciences of Reno, Nevada, is also developing possible pharmaceuticals to maintain telomeres.

An enzyme called telomerase maintains telomeres in our reproductive and stem cells but not in the rest of the body.

Indeed, a non-negligible proportion of cancer cells use recombination instead of telomerase to maintain telomere length.

However, maintaining a healthy lifestyle, including a healthy diet and regular exercise, may also maintain telomere length.

Greider, a Nobel laureate, directs a group of scientists studying both the role of short telomeres in age - related disease and cancer as well as the regulatory mechanism that maintain telomere length.

Anti-aging sirtuin molecules regulate DNA repair, and help to maintain telomere length — an important longevity factor.

Not exact matches

And in cancer cells, which unfortunately do not seem to age, telomere length is maintained virtually indefinitely.

According to the new theory, the telomeres are short in precancerous cells because telomerase is turned on just enough to maintain but not lengthen the telomeres.

«One of our killifish mutants recapitulates, but in a rapid manner, a human disease called Dyskeratosis congenita, which is due to deficits in a complex involved in maintaining the end of chromosomes, or telomeres,» says lead author Dr. Itamar Harel, a postdoctoral research fellow in genetics.

One of them was used to reproduce acquired aplastic anemia: due to various types of damage, some of the stem cells die, and those that remain need to divide more frequently in order to maintain the production of blood cells; as a result of so many divisions, the telomeres shorten and the disease appears.

Telomerase is an enzyme that replicates the ends of chromosomes (sections of DNA called telomeres), replacing the DNA lost when chromosomes are copied before cell division and, therefore, maintaining the stability of the genome.

Just as youthful stem cells use telomerase to offset telomere length loss, cancer cells employ telomerase to maintain their aberrant and destructive growth.

Research from other scientists at Johns Hopkins, he says, had suggested that some tumors, particularly those that affect the nervous system, have mutations in the ATRX gene, which produces proteins that appear to maintain the length of telomeres, repetitive segments of DNA on the ends of chromosomes that typically shorten each time a cell divides.

«And perhaps as a result, they were more susceptible to infections at 6 to 12 months and maintained these short telomeres into adulthood.»

Partial copies of the extrachromosomal ribosomal DNA (rDNA) element are found at the ends of each chromosome, suggesting a novel telomere structure and the use of a common mechanism to maintain both the rDNA and chromosomal termini.

The method by which telomerase and associated regulatory factors physically interact and function with each other to maintain appropriate telomere length is poorly understood.

The enzyme telomerase maintains the length of telomeres, the protective ends on chromosomes, and most cancer cells use large amounts of the enzyme to ensure their immortality.

One of them was used to reproduce acquired aplastic anaemia: due to various types of damage, some of the stem cells die, and those that remain need to divide more frequently in order to maintain the production of blood cells; as a result of so many divisions, the telomeres shorten and the disease appears.

Vitamin D deficiencies are linked to chronic disease, and optimal levels are linked to an actual preservation of our telomeres, the part of your chromosomes that maintain our youth!

For example, Dr. Janossy maintains that detoxifying bone marrow helps the body produce a greater number of stem cells, while helping to enhance the telomeres (the «caps» at the ends of chromosomes that are associated with longevity).

We know that stress increases inflammatory hormonal imbalances which contribute to oxidative stress within the body, and it's been found that meditation can reduce the stress arousal process and may also assist with maintaining healthy telomeres.

that also helps maintain a healthy weight, possibly by producing a compound that acts to protect the telomeres.

Exercise is an important lifestyle choice with anti-aging effects that also helps maintain a healthy weight, possibly by producing a compound that acts to protect the telomeres.

(source) This enzyme maintains or lengthen telomeres, which is significant because telomeres directly impact cellular aging.