Sentences with phrase «major causes of this disease»

For example, Eli Lilly & Co. (NYSE: LLY) has a phase 3 study of solanezumab under way in mild to moderate Alzheimer's disease patients that may slow disease progression by breaking up amyloid plaque buildups thought to be a major cause of the disease.

Residual leukemic cells that remain in the bone marrow following treatment are a major cause of disease relapse and can also act as an early indicator to the effectiveness of a given treatment strategy.

Malignant cells that remain in the bone marrow following treatment are a major cause of disease relapse.

Yes, according to the science of Ayurveda, toxins can be produced inside the digestive system during the process of digestion and can become a major cause of disease.

Many people having read the work of Dr. Robert Young or Edgar Cayce know that over-acidity is a major cause of disease and seek to address this via an alkaline diet.

Practitioners of natural medicine believe that the accumulation of toxins in the body is a major cause of disease.

Once laughed at by conventional medicine, dysbiosis (imbalanced intestinal flora) is now verified to be a major cause of disease.

Stress destroys your body from within and is one of the major causes of disease in today's society.

Obesity of course is a major cause of this disease in both cats and humans and with the reported decline in pet visits to the vet, the condition goes undiagnosed.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

(It should be noted that other major causes of deaths in America include lung disease, car accidents, and Alzheimer's.)

While obesity isn't a major cause of death — that would be cardiovascular disease and cancer — it contributes to shortened life - spans in contemporary society.

Even though alcoholism ranks as one of the country's three major health problems, along with cancer and heart disease; even though it accounts for approximately 98,000 deaths every year; even though it is the root cause of most pastoral - care crises (suicides, auto fatalities, child abuse, divorces, hospital admissions, accidental deaths and home violence); even though it costs the nation $ 120 billion annually in terms of lost work time, health and welfare benefits, property damage, medical expenses, insurance and lost wages; and even though its effects impair the educational process of every child in every classroom, still the church acts as though alcoholism does not exist.

The most common cause of death in young children in developing countries is diarrhea (also a major fatal disease in New York at the turn of the century).

Unfortunately, diet - related chronic diseases are currently a major cause of death and disability among Australians.

A small amount of bleach will kill some major disease causing organisms in water making it safe to drink, cook with, or clean pump parts.

Approximately 175000 cancer cases are diagnosed annually in children younger than age 15 years worldwide, 1 with an annual increase of around 0.9 % in incidence rate in the developed world, only partly explained by improved diagnosis and reporting.1, 2 Childhood cancer is rare and its survival rate has increased significantly over the years owing to advancement in treatment technologies; however, it is still a leading cause of death among children and adolescents in developed countries, ranking second among children aged 1 to 14 years in the United States, surpassed only by accidents.1, 3 Childhood cancer is also emerging as a major cause of death in the last few years in Asia, Central and South America, Northwest Africa, and the Middle East, where death rates from preventable communicable diseases are declining.2

A far - reaching study conducted by scientists at Cincinnati Children's reports that the Epstein - Barr virus (EBV)-- best known for causing mononucleosis — also increases the risks for some people of developing seven other major diseases.

From poisoning and injuring marine life to the ubiquitous presence of plastics in our food to disrupting human hormones and causing major life - threatening diseases and early puberty, the exponential growth of plastics is threatening our planet's survival.

Coronary artery disease is the most common cause of death in the world, and a major cause of hospitalisation.

«RB loss causes a major reprogramming of gene expression, allowing induction of pathways that promote features that induce characteristics of lethal disease,» said senior author Karen Knudsen, PhD, Director of the Sidney Kimmel Cancer Center (SKCC) at Thomas Jefferson University.

Dr McIntyre said: «Using data in this way can help us address the major threat of new diseases and the spread of existing diseases caused by climate change.

Diabetes is the seventh leading cause of death in the United States and a major risk factor for other life - threatening conditions, including heart disease and stroke.

These vulnerable patients, whose immune defenses have taken a dramatic double hit from both their original disease and the treatments required to repopulate their immune system with donor cells, are especially susceptible to a wide range of infections that typically don't cause major problems in healthy people.

According to the Centers for Disease Control and Prevention (CDC), stroke is the fifth leading cause of death in the U.S. and a major cause of adult disability.

They looked for mutations in healthy tissue, and focused on 60 genes known to be a major cause of at least some forms of the disease.

«It is a very major and resource - intensive endeavour to determine the causes of celiac disease.

People around the world are living longer, even in some of the poorest countries, but a complex mix of fatal and nonfatal ailments causes a tremendous amount of health loss, according to a new analysis of all major diseases and injuries in 188 countries.

Longer lifespans in industrialized countries have ballooned the caseload, advancing the disease to a major cause of death.

«Gastrointestinal diseases are a major cause of mortality in wild and captive pandas but scientists understand very little about their digestive process,» says co-author Ashli Brown Johnson, state chemist and Mississippi State University associate professor of biochemistry, molecular biology, entomology and plant pathology.

Kozai explains, «Dysfunction in glial cells has been implicated as a cause and / or major contributor to an increasing number of neurological and developmental diseases.

Dr. Chew leads the Age - Related Eye Disease Study (AREDS), which was designed to investigate a combination of nutritional supplements for slowing age - related macular degeneration (AMD), a major cause of vision loss among older Americans.

'' [H pylori] is the major cause of gastritis (80 percent) and gastroduodenal ulcer disease (15 percent - 20 percent) and the only bacterial pathogen believed to cause cancer,» according to background information in the article.

Both De Luca and Marinkovich's teams are exploring a similar gene therapy for another major form of the disease, called dystrophic EB, caused by a different genetic error affecting a larger protein.

An ill - behaved brain protein that escaped notice for over 90 years has unexpectedly emerged as a major possible cause of Alzheimer's disease.

Hepatic encephalopathy occurs when the liver can not remove certain toxins and chemicals, such as ammonia, from the blood.1 These toxins and chemicals then build up and enter the brain.1 Hepatic encephalopathy is one of the major complications of cirrhosis (scarring of the liver), and a leading cause of hospital re-admission due to its recurrence, despite treatment.1 It can occur suddenly in people with acute liver failure, but is seen more often in those with chronic liver disease.1 Symptoms of hepatic encephalopathy include mild confusion, forgetfulness, poor concentration and personality or mood changes, but can progress to extreme anxiety, seizures, severe confusion, jumbled and slurred speech and slow movement.1 The first step in treatment is to identify and treat any factors that cause hepatic encephalopathy.2 Once the episode has resolved, further treatment aims to reduce the production and absorption of toxins, such as ammonia.1 Generally, there are two types of medication used to reduce the likelihood of another hepatic encephalopathy episode — lactulose and rifaximin.2 However, it remains a leading cause of hospitalisations and re-hospitalisations in cirrhotic patients, despite the use of the above - mentioned standard of care treatment.

These new genomes are «a major step in understanding how this organism causes disease,» says John Iandolo, a microbiologist at the University of Oklahoma, Oklahoma City.

The top causes of death worldwide, ischemic heart diseases and stroke, together with another major source of illness, that is cancer, require proper imaging of blood vessels.

«This one - two punch of discoveries underscores the critical value of basic science — by uncovering the major cause of CD4 T cell depletion in AIDS, Dr. Greene's lab has been able to identify a potential new therapy for blocking the disease's progression and improving on current antiretroviral medications.»

This gene is the major genetic cause of Parkinson's disease, which is a movement disorder.

Waterborne diseases are a major cause of illness in developing countries and are responsible for sporadic and localised outbreaks of disease in the developed world.

Alzheimer's disease, a major source of dementia and memory loss in the elderly, is caused by the accumulation of protein plaques which choke neurons in the brain.

- In a study with potentially major implications for the future treatment of autoimmunity and related conditions, scientists from the Perelman School of Medicine at the University of Pennsylvania have found a way to remove the subset of antibody - making cells that cause an autoimmune disease, without harming the rest of the immune system.

«While the PURE study is a major advance in terms of scope and the use of very careful and consistent methodology, it does not allow us to conclude that low sodium intake causes death and cardiovascular disease outcomes,» she said.

Apps that increase physical activity levels are potentially valuable because insufficient physical activity is the second - leading preventable cause of death in the U.S., with links to heightened risk for major non-communicable diseases.

Dr Mark Ide, first author from the Dental Institute at King's College London says: «Gum disease is widespread in the UK and US, and in older age groups is thought to be a major cause of tooth loss.

Diabetic kidney disease is the leading cause of end - stage kidney disease, which is the eighth leading cause of death in the United States and a major risk factor for cardiovascular disease, the nation's leading killer.

However, preterm infants have an increased risk of developing bronchopulmonary dysplasia (BPD), a serious lung disease, which is a major cause of death and lifelong complications.

«We've found a possible treatment for a toxin that is a major cause of food - and waterborne disease in the world,» Linstedt says.

Clostridium difficile - associated disease (CDAD) is the major known cause of antibiotic - induced diarrhea and colitis, and the disease is thought to result from persistent disruption of commensal gut microbiota.