Sentences with phrase «major cellular damage»

Not exact matches

Based on the previous evidences, it rusults important to maintain cellular NAD + availability especially in mitochondria when stresses induce a major consumption of NAD + and ATP and prone the organism more susceptible to ROS damages.

DNA damage is repairable, but PARPS consume up to 80 % of available NAD + in older humans, meaning it is a major cause of NAD + shortage, leaving less NAD + for cellular respiration, fighting inflammation, and disease (21)