Sentences with phrase «major cognitive defects»
In 2013, a team led by Gerard Karsenty, the Paul A. Marks Professor and chair of the department of genetics and development at Columbia University Medical Center, showed that mice lacking osteocalcin have major cognitive defects.
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After creating a pathological mouse model deficient for this gene, through the Gencodys Consortium (Genetic and Epigenetic Networks in Cognitive Dysfunction; http://www.gencodys.eu/), scientists from PHENOMIN and the IGBMC showed major memory defects, as well as significant symptoms of hyperactivity on this model.