Sentences with phrase «major diseases of our age»

This is perplexing, considering that it's well - established that the major diseases of our age, including heart disease, type - 2 diabetes, and colon cancer, are all largely caused by unhealthy diet and lifestyle practices (1, 10, 14).

Not exact matches

Approximately 175000 cancer cases are diagnosed annually in children younger than age 15 years worldwide, 1 with an annual increase of around 0.9 % in incidence rate in the developed world, only partly explained by improved diagnosis and reporting.1, 2 Childhood cancer is rare and its survival rate has increased significantly over the years owing to advancement in treatment technologies; however, it is still a leading cause of death among children and adolescents in developed countries, ranking second among children aged 1 to 14 years in the United States, surpassed only by accidents.1, 3 Childhood cancer is also emerging as a major cause of death in the last few years in Asia, Central and South America, Northwest Africa, and the Middle East, where death rates from preventable communicable diseases are declining.2

«There were four major events in the 19th century that removed medicine from its dark ages: the discovery of anesthesia, the discovery of antiseptic principles, the discovery of the germ theory of disease, and the discovery of the X-ray,» Burns says.

«We've known that aging is a major risk factor for most chronic diseases for some time, but recently, we've gained a better understanding of the aging process's basic underpinnings, which has allowed us to extend both life span and health — in animals at least,» says Felipe Sierra, director of the Division of Aging Biology at the National Institute on Aaging is a major risk factor for most chronic diseases for some time, but recently, we've gained a better understanding of the aging process's basic underpinnings, which has allowed us to extend both life span and health — in animals at least,» says Felipe Sierra, director of the Division of Aging Biology at the National Institute on Aaging process's basic underpinnings, which has allowed us to extend both life span and health — in animals at least,» says Felipe Sierra, director of the Division of Aging Biology at the National Institute on AAging Biology at the National Institute on AgingAging.

Obesity and a bigger waist size in older women are associated with a higher risk of death, major chronic disease and mobility disability before the age of 85, according to a study published by JAMA Internal Medicine, a JAMA Network publication.

«Having a healthy BMI or WC was associated with a higher likelihood of surviving to older ages without a major disease or mobility disability,» the study concludes.

Cohen's first breakthrough in this area occurred when he discovered, working with worms, that reducing the activity of the signaling mechanism conveyed through insulin and the growth hormone IGF1, a major aging regulating pathway, constituted a defense against the aggregation of the Aβ protein which is mechanistically - linked with Alzheimer's disease.

Dr. Chew leads the Age - Related Eye Disease Study (AREDS), which was designed to investigate a combination of nutritional supplements for slowing age - related macular degeneration (AMD), a major cause of vision loss among older AmericaAge - Related Eye Disease Study (AREDS), which was designed to investigate a combination of nutritional supplements for slowing age - related macular degeneration (AMD), a major cause of vision loss among older Americaage - related macular degeneration (AMD), a major cause of vision loss among older Americans.

New findings from large - scale studies of more than 3.6 million people who underwent screening for cardiovascular disease reveals that a person's age and gender affects the prevalence of certain types of peripheral vascular diseases (PVD), and that diabetes is a major risk factor for developing these diseases, even in patients without heart disease.

During 2015 Nottingham's cloned sheep underwent a series of comprehensive assessments for non-communicable diseases including obesity, hypertension and osteoarthritis — three major comorbidities in aged human populations.

Dr Mark Ide, first author from the Dental Institute at King's College London says: «Gum disease is widespread in the UK and US, and in older age groups is thought to be a major cause of tooth loss.

«But at such a tender age, the risks of major surgery, compounded by severe cardiac disease caused by his genetic syndrome, are traditionally prohibitive.»

Influenza remains a major health problem in the United States, resulting each year in an estimated 36,000 deaths and 200,000 hospitalizations.4 Those who have been shown to be at high risk for the complications of influenza infection are children 6 to 23 months of age; healthy persons 65 years of age or older; adults and children with chronic diseases, including asthma, heart and lung disease, and diabetes; residents of nursing homes and other long - term care facilities; and pregnant women.4 It is for this reason that the Centers for Disease Control and Prevention (CDC) has recommended that these groups, together with health care workers and others with direct patient - care responsibilities, should be given priority for influenza vaccination this season in the face of the current shortage.1 Other high - priority groups include children and teenagers 6 months to 18 years of age whose underlying medical condition requires the daily use of aspirin and household members and out - of - home caregivers of infants less than 6 months old.1 Hence, in the case of vaccine shortages resulting either from the unanticipated loss of expected supplies or from the emergence of greater - than - expected global influenza activity — such as pandemic influenza, which would prompt a greater demand for vaccination5 — the capability of extending existing vaccine supplies by using alternative routes of vaccination that would require smaller doses could have important public health implicdisease, and diabetes; residents of nursing homes and other long - term care facilities; and pregnant women.4 It is for this reason that the Centers for Disease Control and Prevention (CDC) has recommended that these groups, together with health care workers and others with direct patient - care responsibilities, should be given priority for influenza vaccination this season in the face of the current shortage.1 Other high - priority groups include children and teenagers 6 months to 18 years of age whose underlying medical condition requires the daily use of aspirin and household members and out - of - home caregivers of infants less than 6 months old.1 Hence, in the case of vaccine shortages resulting either from the unanticipated loss of expected supplies or from the emergence of greater - than - expected global influenza activity — such as pandemic influenza, which would prompt a greater demand for vaccination5 — the capability of extending existing vaccine supplies by using alternative routes of vaccination that would require smaller doses could have important public health implicDisease Control and Prevention (CDC) has recommended that these groups, together with health care workers and others with direct patient - care responsibilities, should be given priority for influenza vaccination this season in the face of the current shortage.1 Other high - priority groups include children and teenagers 6 months to 18 years of age whose underlying medical condition requires the daily use of aspirin and household members and out - of - home caregivers of infants less than 6 months old.1 Hence, in the case of vaccine shortages resulting either from the unanticipated loss of expected supplies or from the emergence of greater - than - expected global influenza activity — such as pandemic influenza, which would prompt a greater demand for vaccination5 — the capability of extending existing vaccine supplies by using alternative routes of vaccination that would require smaller doses could have important public health implications.

She directed The Johns Hopkins Center of Excellence for Aging Research, the Center on Aging and Health, and the Division of Geriatric Medicine and Gerontology, and led major multidisciplinary research programs on the causes and consequences of frailty, cardiovascular disease, cognitive impairment and disability in older adults, and approaches to prevention.

Senescent cells also promote inflammation, which is a common feature of all major age - related diseases.

In HD, the length of a person's CAG expansion is a major factor in the age of disease onset.

Mechanisms that link tumor suppression and the development of cancer to aging and the major diseases associated with aging

SALT LAKE CITY — Two major eye diseases and leading causes of blindness — age - related macular degeneration and diabetic retinopathy — can be reversed or even prevented by drugs that activate a protein found in...

LysoSENS - I always believe in sole one (might be to hopeful with bacterial enzyme - filled nanorobots clearing lipofuscin) Reversing Heart Disease, not just heart disease, reverting the major age pigment accumulation problem - lipofuscin in lysosomes that is a major cause of aging (by blocking the proteasome, blocking autophagy and mitophagy process (critical for cell surDisease, not just heart disease, reverting the major age pigment accumulation problem - lipofuscin in lysosomes that is a major cause of aging (by blocking the proteasome, blocking autophagy and mitophagy process (critical for cell surdisease, reverting the major age pigment accumulation problem - lipofuscin in lysosomes that is a major cause of aging (by blocking the proteasome, blocking autophagy and mitophagy process (critical for cell survival).

Moreover, PHENONIM - ICS is involved in European projects presenting a strong impact on human health: Interreg CARDIOGENE (Genetic mechanisms of cardiovascular diseases), GENCODYS (Genetic and epigenetic networks involved in cognitive dysfunctions), AgedBrainSYSBIO (Basic studies of brain aging), as well as projects in partnership with industry: MAGenTA (an Industrial Strategic Innovation project supported by Bpifrance about the treatment of major urogenital diseases) and CanPathPro (H2020 program), to develop a predictive modeling platform of signaling pathways involved in cancers.

In my own lab here at Indiana University School of Medicine, I am bringing some of those chemical biology techniques to bear on problems in eye disease and we continue to work on tumors of the eye, but we also developed a major focus on neovascular eye diseases, including wet, age - related macular degeneration (AMD).

First Major Gene Mutation for Hereditary Prostate Cancer Found After a 20 - year quest to find a genetic driver for prostate cancer that strikes men at younger ages and runs in families, researchers have identified a rare, inherited mutation linked to a significantly higher risk of the disease.

«The aging process itself is the main risk factor in cardiac disease, cancer, Alzheimer's and other major causes of death for humans,» says Harel.

The major drug companies make most of their profits on blockbuster drugs aimed at one of the above degenerative diseases of aging.

USC's Dr. Valter Longo has created the Fast Mimicking Diet, a five day partial eating diet that in research decreased risk factors / biomarkers for aging, diabetes, cardiovascular disease, and cancer without major adverse effects, providing support for the use of FMDs to promote healthspan.

Besides oxidation, glycation and the subsequent formation of AGEs is one of the major molecular mechanisms causing ongoing damage in your body, which leads to disease, (premature) aging and, eventually, death.

Some scientists feel that the failure of autophagy to keep pace with the accumulation of cellular debris is a major cause of chronic diseases linked to aging, says Dr. Andrew Weil, noted Holistic Health physician.

When consumed in excess, sugar acts as a toxin and drives multiple disease processes in your body, not the least of which is insulin resistance, a major cause of accelerated aging.

The major benefits of a strength program include looking trimmer and more youthful as one ages; increased metabolism and weight management; reduced stress and depression; prevention of the onset of diseases such as arthritis, osteoporosis, diabetes, hypertension and high cholesterol.

In fact, cells damage caused by free radicals appears to be a major contributor to aging and diseases, including cancer, heart disease, and weakening of immune system (2).

Obstructive sleep apnea and other symptoms of OSA are associated with probable major depression, regardless of factors like weight, age, sex or race, according to a new study from the Centers for Disease Control and Prevention.

It's the major component of our connective tissue, skin and bones, but as we age, collagen production tapers off, our skin wrinkles, and we become vulnerable to diseases such as osteoporosis.

The ongoing attack on DNA by free radicals is thought to play a major role in the age - related development of many diseases including cancer.

Oxidative stress and chronic inflammation are believed to reduce cellular antioxidant capacity and are deemed a major cause of age - related diseases and cancer, according to the National Institutes of Health.

It is believed to be a major cause of aging and various chronic diseases.

It's a fitting acronym because — along with oxidation — it's one of the major molecular mechanisms whereby damage accrues in your body, which leads to disease, aging and eventually death.

From literatures, it is apparent that there is a general concept that chronic inflammation can be a major cause of cancers and express aging processes... studies suggest that chronic inflammation could have serious roles in a wide variety of age - related diseases including diabetes, cardiovascular and autoimmune diseases.

«Modulating this crucial balance of pro- and anti-inflammatory processes has become a major focus of new geroscientific approaches that are attempting to more successfully treat - or prevent - major age - related diseases.»

Along with the chemo - preventive efficiency, asparagus also helps in elevating the levels of glutathione, an antioxidant and a detoxifying compound which plays a major role in aging and helps in the prevention of many diseases like HIV, AIDS, cystic fibrosis, Alzheimer's disease, anemia, cancer, diabetes, and various cardiac disorders.

In this article, we will review a host of new studies that detail the impact of vitamin K supplementation on preventing these and other major age - related diseases.

Free radicals play a major role in the development of degenerative diseases, strokes, cardiovascular diseases and aging.

«Our dietary choices play a major role in determining whether we are going to live into our 80s and 90s and even beyond with a good, functioning brain or like 50 % of people who live to be age 85, we will experience brain decline in the form of Alzheimer's which is a preventable disease.»

Increasing numbers of school age children with allergic disease is presenting schools with a major challenge around how to make school life for pupils with allergic disease as safe as possible.

Spaying at an early age prevents diseases of the ovaries and infections of the uterus, which are a major cause of illness in unspayed pets.

Any Scottie 7 years of age or older, with no evidence of urinary tract disease, in good health, with no diagnosis of any cancer or major organ dysfunction.

He says oral care is a particular concern with special - needs dogs, since aging, disease or medications can compromise the quantity or quality of saliva — a major component of oral health.

The biggest thing is making sure you can qualify for life insurance with SBLI, so lets cover (in general) what SBLI will and won't insure: SBLI Underwriting Uninsurable medical scenarios with SBLI: • Aids / HIV + status • ALS (Amyotrophic Lateral Sclerosis) • Alzheimer's disease or dementia or significant cognitive impairments related to functionality • Cancer diagnosis within last 2 years • Chronic pain treatment, severe, receiving disability, narcotic use • Cirrhosis of the Liver • Congestive heart Failure • COPD / Emphysema or chronic bronchitis - Severe or with current nicotine use • Cystic Fibrosis • Defibrillator use • Depression, severe, recurrent or with multiple in - patient hospitalization history • Diabetes with co-morbidities that include significant cardiac disease, or impairment of renal function or mobility • Heart / Cardiac Disease - multiple vessels diagnosed within 2 years or any past history with current nicotine use • Muscular Dystrophy • Multiple Sclerosis, if symptoms progressing • Organ Transplants, in most scenarios • Quadriplegia • Pulmonary hypertension • Renal failure, Renal insufficiency - severe • Stroke within 1 year • Suicide attempt within 5 years • Surgical repair of heart valves, aneurysms, intracranial tumors, major organs within six months, including gastric bypass Uninsurable non-medical scenarios: • Marijuana use, 4 or more times weekly • Substance abuse / misuse within last 5 years • Criminal activity - any history within the last 10 years • DUI, more than 2 or under age 25 if within 1 year • Unemployed (other than homemakers or retired) with minimal household income or dependent on SSI / disability benefits • Bankruptcy filing within 2 years • Liens / Judgements - outstanding activity that exceeddisease or dementia or significant cognitive impairments related to functionality • Cancer diagnosis within last 2 years • Chronic pain treatment, severe, receiving disability, narcotic use • Cirrhosis of the Liver • Congestive heart Failure • COPD / Emphysema or chronic bronchitis - Severe or with current nicotine use • Cystic Fibrosis • Defibrillator use • Depression, severe, recurrent or with multiple in - patient hospitalization history • Diabetes with co-morbidities that include significant cardiac disease, or impairment of renal function or mobility • Heart / Cardiac Disease - multiple vessels diagnosed within 2 years or any past history with current nicotine use • Muscular Dystrophy • Multiple Sclerosis, if symptoms progressing • Organ Transplants, in most scenarios • Quadriplegia • Pulmonary hypertension • Renal failure, Renal insufficiency - severe • Stroke within 1 year • Suicide attempt within 5 years • Surgical repair of heart valves, aneurysms, intracranial tumors, major organs within six months, including gastric bypass Uninsurable non-medical scenarios: • Marijuana use, 4 or more times weekly • Substance abuse / misuse within last 5 years • Criminal activity - any history within the last 10 years • DUI, more than 2 or under age 25 if within 1 year • Unemployed (other than homemakers or retired) with minimal household income or dependent on SSI / disability benefits • Bankruptcy filing within 2 years • Liens / Judgements - outstanding activity that exceeddisease, or impairment of renal function or mobility • Heart / Cardiac Disease - multiple vessels diagnosed within 2 years or any past history with current nicotine use • Muscular Dystrophy • Multiple Sclerosis, if symptoms progressing • Organ Transplants, in most scenarios • Quadriplegia • Pulmonary hypertension • Renal failure, Renal insufficiency - severe • Stroke within 1 year • Suicide attempt within 5 years • Surgical repair of heart valves, aneurysms, intracranial tumors, major organs within six months, including gastric bypass Uninsurable non-medical scenarios: • Marijuana use, 4 or more times weekly • Substance abuse / misuse within last 5 years • Criminal activity - any history within the last 10 years • DUI, more than 2 or under age 25 if within 1 year • Unemployed (other than homemakers or retired) with minimal household income or dependent on SSI / disability benefits • Bankruptcy filing within 2 years • Liens / Judgements - outstanding activity that exceedDisease - multiple vessels diagnosed within 2 years or any past history with current nicotine use • Muscular Dystrophy • Multiple Sclerosis, if symptoms progressing • Organ Transplants, in most scenarios • Quadriplegia • Pulmonary hypertension • Renal failure, Renal insufficiency - severe • Stroke within 1 year • Suicide attempt within 5 years • Surgical repair of heart valves, aneurysms, intracranial tumors, major organs within six months, including gastric bypass Uninsurable non-medical scenarios: • Marijuana use, 4 or more times weekly • Substance abuse / misuse within last 5 years • Criminal activity - any history within the last 10 years • DUI, more than 2 or under age 25 if within 1 year • Unemployed (other than homemakers or retired) with minimal household income or dependent on SSI / disability benefits • Bankruptcy filing within 2 years • Liens / Judgements - outstanding activity that exceeds $ 50K

Given that old age is a primary cause of diseases, the fact that there is no maximum entry age is a major bonus.

Main Outcome Measures At age 32 years, study members were assessed for the presence of 3 age - related - disease risks: major depression, high inflammation levels (high - sensitivity C - reactive protein level > 3 mg / L), and the clustering of metabolic risk biomarkers (overweight, high blood pressure, high total cholesterol, low high - density lipoprotein cholesterol, high glycated hemoglobin, and low maximum oxygen consumption levels.

Globally, harmful alcohol use is a major modifiable contributor to the burden of disease.1 The typical age of initiation of alcohol use is around mid-adolescence and for a significant minority of adolescents their alcohol use will result in substantial harms, the most costly of which is alcohol use disorder (AUD).2 Defined as a cluster of symptoms indicating continued alcohol use despite significant problems, AUD is common and imposes a significant burden on the individual, their family and the wider society.