Sentences with phrase «major economic costs»

This poses major economic costs and human risks, although these impacts are closely linked to the design of the structure.

Not exact matches

Sidenote: Chew is also one of the few biopharma execs I've ever spoken to who voluntarily brought up the Institute for Clinical and Economic Review (ICER), a tough drug pricing critic organization which insists on proven outcomes (and has consequently become a major biopharma gadfly), because the group actually validated the cost - effectiveness of Omada's tech.

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Actual operational and financial results of SkyWest, SkyWest Airlines and ExpressJet will likely also vary, and may vary materially, from those anticipated, estimated, projected or expected for a number of other reasons, including, in addition to those identified above: the challenges and costs of integrating operations and realizing anticipated synergies and other benefits from the acquisition of ExpressJet; the challenges of competing successfully in a highly competitive and rapidly changing industry; developments associated with fluctuations in the economy and the demand for air travel; the financial stability of SkyWest's major partners and any potential impact of their financial condition on the operations of SkyWest, SkyWest Airlines, or ExpressJet; fluctuations in flight schedules, which are determined by the major partners for whom SkyWest's operating airlines conduct flight operations; variations in market and economic conditions; significant aircraft lease and debt commitments; residual aircraft values and related impairment charges; labor relations and costs; the impact of global instability; rapidly fluctuating fuel costs, and potential fuel shortages; the impact of weather - related or other natural disasters on air travel and airline costs; aircraft deliveries; the ability to attract and retain qualified pilots and other unanticipated factors.

Of course it matters to anyone who wants to understand the economic cost of the adjustment, but arguments about whether the reported data are overstated, and by how much, have become part of the bull vs bear debate about whether Chinese growth is merely slowing temporarily, and not as part of a major economic reversal of the growth model.

Unlike other crisis - hit countries such as Spain and Greece, Italy has yet to implement major economic overhauls or to push down labor and other business costs to levels that would make its industries more competitive abroad.

While it is too early to assess the economic cost of the south Asian tsunami fully, at this stage the overall impact on GDP is expected to be limited as the major population and industrial centres were largely undamaged.

While you shouldn't move overseas solely because a country is a cheap place to live, in today's current economic climate, cost of living is a major factor.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

Lack of breast feeding is significantly associated with higher use and cost of health care.28 Improved short and long term health of breastfed children, improved wellbeing of mothers who have breast fed, and the cost of goods consumed are major factors leading to economic benefits from the promotion of breast feeding.6 29 30 31 Future research should compare the specific cost effectiveness of such strategies for improvement of breastfeeding practice.

Kinderhook, NY — April 5, 2016... Citing New York's outrageous property taxes as a major cause of Upstate's economic decline, Congressional candidate John Faso (R - Kinderhook) today announced that, if elected, he will introduce legislation amending federal law (42 USC 1396a) to eliminate a state's ability to impose a local government share of Medicaid costs.

«The EPSERP will have a major positive impact on the private sector through the substantial reduction in the cost of doing business for all economic sectors, particularly in the formal and informal manufacturing and service activities which are seriously constrained by the power supply gaps.

«We need Europe to wake up to the costs of agricultural protectionism and also what we have seen in the last few months - restrictive practices by some of the major economies in Europe where they are blocking takeovers and trying to operate what are called economic patriot policies,» he said.

One could frame the debate in the advantages of using less fossil fuel, which range from lower costs to people (an all electric car has operating costs about 1/4 that of a gasoline vehicle), to balance of payments (less capital flowing out of the country, especially relevant to countries who import most of their oil), to terrorism (not funding it, and western influence leaving the ME, which is the basis of most ME terrorist organizations) to conflict in general (most of the major conflicts in the last 30 years have involved ME oil), to finite supply (when we run out, we'll be facing a global economic meltdown).

Major issues also included reducing municipal pension costs and reducing regulations to spur economic growth.

The paper estimates the Total Cost of major NPP Promises in their manifesto and assesses the Party's proposed tax cuts on economic growth and revenue generation to finance the cost of the promiCost of major NPP Promises in their manifesto and assesses the Party's proposed tax cuts on economic growth and revenue generation to finance the cost of the promicost of the promises.

Abstract The paper estimates the Total Cost of major NPP Promises in their manifesto and assesses the Party's proposed tax cuts on economic growth and revenue generation to finance the cost of the promiCost of major NPP Promises in their manifesto and assesses the Party's proposed tax cuts on economic growth and revenue generation to finance the cost of the promicost of the promises.

Failing to address these issues will have major human, social and economic costs.

As high cost of petrol pump price cripples economic activities in Akwa Ibom state, the leadership of the state Chapter of Independent Petroleum Marketers Association of Nigeria (IPMAN), has accused Major Oil Marketers Association of Nigeria (MOMAN) for the high cost of the product in the state

Poor sanitation can demand high environmental cleanup costs, and are a major drag on economic growth, notes Jaehyang So, manager of the Water and Sanitation Program at the World Bank.

Mark Hildebrand, a researcher at the Scripps Institution of Oceanography at the University of California, San Diego, says, «A major consideration» in development of such technology «is the economic costs of production.»

The Organisation for Economic Co-operation and Development (OECD) says that taxes in major economies are far below the cost of pollution from the use of fossil fuels on climate and the environment, urging governments to do more to make polluters pay.

Brain illness, comprising neurological disorders, mental illness and addiction, is considered the major health challenge in the 21st century with a socio - economic cost greater than cancer and cardiovascular disease combined.

Intestinal parasite damage is difficult to spot, but intestinal worms can cause major economic losses as a result of inefficient growth, lack of uniformity and increased production costs.

Recognizing the need to support curatorial talent and provide low - cost practical training in the current economic climate, Independent Curators International (ICI) initiated the Curatorial Intensive — the first major short - course training program for emerging curators in the United States.

The Organisation for Economic Co-operation and Development (OECD) says that taxes in major economies are far below the cost of pollution from the use of fossil fuels on climate and the environment, urging governments to do more to make polluters pay.

Gasoline indirect cost calculated based on International Center for Technology Assessment (ICTA), The Real Price of Gasoline, Report No. 3 (Washington, DC: 1998), p. 34, and updated using ICTA, Gasoline Cost Externalities Associated with Global Climate Change: An Update to CTA's Real Price of Gasoline Report (Washington, DC: September 2004), ICTA, Gasoline Cost Externalities: Security and Protection Services: An Update to CTA's Real Price of Gasoline Report (Washington, DC: January 2005), Terry Tamminen, Lives Per Gallon: The True Cost of Our Oil Addiction (Washington, DC: Island Press, 2006), p. 60, and Bureau for Economic Analysis, «Table 3 — Price Indices for Gross Domestic Product and Gross Domestic Purchases,» GDP and Other Major Series, 1929 — 2007 (Washington, DC: August 2007); U.S. Department of Energy (DOE), Energy Information Administration (EIA), This Week in Petroleum (Washington, DC: various issucost calculated based on International Center for Technology Assessment (ICTA), The Real Price of Gasoline, Report No. 3 (Washington, DC: 1998), p. 34, and updated using ICTA, Gasoline Cost Externalities Associated with Global Climate Change: An Update to CTA's Real Price of Gasoline Report (Washington, DC: September 2004), ICTA, Gasoline Cost Externalities: Security and Protection Services: An Update to CTA's Real Price of Gasoline Report (Washington, DC: January 2005), Terry Tamminen, Lives Per Gallon: The True Cost of Our Oil Addiction (Washington, DC: Island Press, 2006), p. 60, and Bureau for Economic Analysis, «Table 3 — Price Indices for Gross Domestic Product and Gross Domestic Purchases,» GDP and Other Major Series, 1929 — 2007 (Washington, DC: August 2007); U.S. Department of Energy (DOE), Energy Information Administration (EIA), This Week in Petroleum (Washington, DC: various issuCost Externalities Associated with Global Climate Change: An Update to CTA's Real Price of Gasoline Report (Washington, DC: September 2004), ICTA, Gasoline Cost Externalities: Security and Protection Services: An Update to CTA's Real Price of Gasoline Report (Washington, DC: January 2005), Terry Tamminen, Lives Per Gallon: The True Cost of Our Oil Addiction (Washington, DC: Island Press, 2006), p. 60, and Bureau for Economic Analysis, «Table 3 — Price Indices for Gross Domestic Product and Gross Domestic Purchases,» GDP and Other Major Series, 1929 — 2007 (Washington, DC: August 2007); U.S. Department of Energy (DOE), Energy Information Administration (EIA), This Week in Petroleum (Washington, DC: various issuCost Externalities: Security and Protection Services: An Update to CTA's Real Price of Gasoline Report (Washington, DC: January 2005), Terry Tamminen, Lives Per Gallon: The True Cost of Our Oil Addiction (Washington, DC: Island Press, 2006), p. 60, and Bureau for Economic Analysis, «Table 3 — Price Indices for Gross Domestic Product and Gross Domestic Purchases,» GDP and Other Major Series, 1929 — 2007 (Washington, DC: August 2007); U.S. Department of Energy (DOE), Energy Information Administration (EIA), This Week in Petroleum (Washington, DC: various issuCost of Our Oil Addiction (Washington, DC: Island Press, 2006), p. 60, and Bureau for Economic Analysis, «Table 3 — Price Indices for Gross Domestic Product and Gross Domestic Purchases,» GDP and Other Major Series, 1929 — 2007 (Washington, DC: August 2007); U.S. Department of Energy (DOE), Energy Information Administration (EIA), This Week in Petroleum (Washington, DC: various issues).

But there are three other major energy options that need to be considered to help fill this need for non-fossil energy by 2050, one or all of which may end up being more cost effective and thus less harmful to global economic growth: nuclear fission (chapter 7), fusion (chapter 8), and solar power collected in space rather than on Earth's surface (chapter 9).

Over the last couple of weeks, I've seen four major reports (details over the fold) from very different sources, all making the same point: decarbonizing the world economy will involve economic costs that are (a) small; and (b) far outweighed by the benefits And, the empirical evidence so far is strong.

The only thing that we can do at this point to reduce this projected rise, and the ancillary human and economic costs, is to greatly reduce carbon emissions which will involve a 30 year lag time for major atmospheric improvement.

You would think then that having the landfill last as long as possible would be a reasonable economic goal since the major costs are the initial startup and preparation expenses and not the operational expenses found in most enterprises.

Addressing the environmental and economic costs of oil is a major goal of Oregon's Clean Fuels Program, a flexible but ambitious program reauthorized in 2015 by the Oregon State Legislature.

The estimated economic costs are modest and major changes in Australia's economic structure would be unlikely as a result.

An analysis of the major economic climate models shows that the global benefits of temperature rises of up to 3 F to 4 F outweigh the costs.

Marine renewables could provide major economic benefits to the UK, while generating low - carbon power at low cost, according to a new report.

With economic public goods, it is usually difficult to determine and reach agreement on efficient policies because they involve estimating and balancing costs and benefits, where neither is easy to measure and both involve major distributional concerns.

88 % of respondents cited the compelling economic case for renewable electricity as a major driver — with 30 out of 74 reporting that renewable electricity was either cost competitive or delivered significant savings on energy bills;

The difference between Professor Nordhaus's optimal carbon tax policy and a fifty - year delay policy is insignificant economically or climatologically in view of major uncertainties in (1) future economic growth (including reductions in carbon emissions intensity); (2) the physical science (e.g., the climate sensitivity); (3) future positive and negative environmental impacts (e.g., the economic «damage function»); (4) the evaluation of long - term economic costs and benefits (e.g., the discount rate); and (5) the international political process (e.g., the impact of less than full participation).

... is a major new international initiative to analyse and communicate the economic benefits and costs of acting on climate change.

There's not really room on TreeHugger to go into all the nuances of why these different visions of economic planning have failed to protect Mother Earth from her rapacious creation known as homo sapiens doing its darndest to commit matricide, but the quick version is this: There has been no major economic system to date that has properly valued the environment, incorporating the true and full costs of depleting natural resources into the price paid for those resources.

We aren't willing to spend 5 % of GDP on a 1 in a million chance of that, and even less willing to spend that kind of money on an unlikely event that is adaptable to without major loss of life, just major economic (and social disruption and ecosystem) cost, should it strike.

People have responded successfully to other major environmental challenges such as acid rain and the ozone hole with benefits greater than costs, and scientists working with economists believe there are ways to manage the risks of climate change while balancing current and future economic prosperity.

WEO - 2017, the International Energy Agency's flagship publication, finds that over the next two decades the global energy system is being reshaped by four major forces: the United States is set to become the undisputed global oil and gas leader; renewables are being deployed rapidly thanks to falling costs; the share of electricity in the energy mix is growing; and China's new economic strategy takes it on a cleaner growth mode, with implications for global energy markets.

New nuclear projects in France and Finland have repeated the familiar problems of construction delays and major cost overruns, while wind power has been claimed as more economic in some contexts.

It's also another cost for employers, particularly at a time of major economic and political uncertainty.

Accordingly, anti-age discrimination in employment law aims at promoting various purposes to remedy these wrongs, including preventing opportunistic behaviour by employers, who are tempted to dismiss older workers when their labour costs are higher than their marginal productivity; promoting displaced older workers who experience major challenges to reemployment; protecting against ageist stereotypes and ageism; and alleviating social isolation, oppression and economic deprivation among older workers.

In many cases, these projects would create thousands upon thousands of jobs for Canadians... Unfortunately, there are environmental and other radical groups that would seek to block this... Their goal is to stop any major project no matter what the cost to Canadian families in lost jobs and economic growth.

Though $ 1,000 / hour billing rates aren't scaring off large firm clients, the high cost of lawyers» fees, particularly in recessionary economic times, is a major factor driving the growth of pro se representation, reports USA Today.

Mental health problems affect around one in five youth in Australia and internationally, 1 with major personal, societal and economic ramifications.2 3 Children's mental health problems are primarily externalising (eg, oppositional defiance, aggression) and internalising (eg, anxiety, depression) problems.1 Up to 50 % of preschool behaviour problems persist through childhood if left untreated, then into adolescence and adulthood.4 Approaches to improving children's mental health in the population would ideally involve effective prevention in addition to clinical treatment of severe problems.5 6 Behavioural parenting programmes have the strongest evidence of efficacy to date for treating children's established behaviour problems.2 7, — , 10 Although effective, parenting programmes to treat children's established behaviour problems are cost - and time - intensive, and require an available workforce trained in evidence - based treatments.

Poor nutrition is a major determinant of excess morbidity and mortality among Aboriginal and Torres Strait Islander peoples, 1 contributing to over 16 % of the burden of disease.2 In this issue of the Journal (page 549), consistent with the «economics of food choice» theory, 3 Brimblecombe and O'Dea report that the diet of a remote Aboriginal community was high in energy - dense, nutrient - poor foods — the cheapest options to satisfy hunger.4 This energy — cost differential restricts access to healthy food, and helps explain the persistently poor dietary patterns and deplorable health status of remote Indigenous communities.4 Placing nutrition issues in an economic framework highlights the investment required to improve Indigenous nutrition.4 But what has been learned to date about where resources should be directed?