Sentences with phrase «major epidemics of»

One of the first major epidemics of the disease in the U.S., it devastated America's early capital.

Ingmar Bergman's famous 1957 movie The Seventh Seal takes place during the 14th century, when Europe is in the midst of a major epidemic of the bubonic plague — the Black Death — which ultimately killed about half the population.

While we have a major epidemic of obesity, we have a parallel epidemic of younger people trying to achieve unhealthily low body weights.»

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

President Donald Trump made combating America's opioid addiction and prescription painkiller epidemic a major plank of his 2016 campaign.

It's been a busy week for health care news between some high - profile setbacks for certain major cancer drug makers, high - profile victories for others, the confirmation of a new FDA chief, health care merger drama, and a slew of public health reports about the opioid epidemic, hepatitis C, and U.S. life expectancy.

During President Donald Trump's «major briefing» on the opioid epidemic Tuesday, he said it was «a problem the likes of which we have never seen.»

«Acapulco is the state of Guerrero, and Guerrero is a major heroin - producing state, and right now heroin is a very lucrative market because we're suffering from an epidemic here in the United States,» Vigil told Business Insider.

A partial but not complete list of worries includes: China melt down, Yuan reevaluation after effects or Taiwan action, global biomedical epidemics, e.g. Avian Flu, or bioterrorism outbreaks, trade wars (China, EU), major hedge fund bankruptcies, a PBGC (Pension Benefit Guaranty Corp.) shortfall crisis, major junk bond or emerging market bond default, a bank derivative blowup, Fannie Mae issues plus possible assorted natural disasters.

The report is one of the first from a major Wall Street bank focused on the growing epidemic killing more than 90 Americans every day.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

Panama was one of the first countries to experience major epidemics.

Considering this year there will be 78 million members of the Immoral Majority («moms and dads» of aborted children), yes indeed abortion will be a major topic in this election as will be the S - TD epidemic.

And when I started looking into health statistics, I realized that there is a major health epidemic among Black women in this country that is hidden under the veneer of strength.

The Australian Beef industry is recognized as being free of all major epidemic diseases of cattle including Foot and Mouth Disease (FMD) and is one of the few in the world to be declared a «Negligible Risk» country of Bovine Spongiform Encephalopathy (BSE) by the World Organization for Animal Health Industry.

The researchers were surprised with the findings: «This was a major surprise for us — that soybean oil is causing more obesity and diabetes than fructose — especially when you see headlines everyday about the potential role of sugar consumption in the current obesity epidemic.

As the leading nonprofit health and fitness certification organization, our mission is to get people moving, because we believe physical activity can play a major role in preventing and reversing the epidemic of chronic, lifestyle - related diseases spreading the globe.

I think that medicalized birth practices resulting in inter-generational deprivation of our basic human rights has been a major contributor epidemics of diabetes and obesity and mental health problems.

Some members of the Erie County Legislature and the Comptroller's Office are criticizing County Executive Mark Poloncarz for trying to shell out big bucks on a long list of county programs — including major priorities like the heroin drug epidemic — with some of an $ 18 millions surplus they're not sure exists entirely.

Moderated by Pattern's President & CEO Jonathan Drapkin, the three county executives discussed some of the major issues facing the lower Hudson Valley, including high taxes, the opioid epidemic, and the need for infrastructure upgrades.

Nielsen pointed to remarks Poloncarz made at a recent Opiate Epidemic Task Force meeting, where he touted Erie County's recent lawsuit filing against major pharmaceutical companies for misrepresenting the addictive properties of their opioid - based painkillers.

Erie County is celebrating the first major sign of success in its battle against the opioid epidemic.

EAST NEW YORK — The six major mayoral candidates accused Mayor Michael Bloomberg of turning his back on the victims of Superstorm Sandy Thursday night, and warned the mold epidemic that has emerged in its wake is now a public health emergency.

«Holding major financial companies accountable for misdeeds, securing safer streets, addressing the heroin epidemic, protecting consumers from fraud and standing up against wage theft are just some of the ways Eric Schneiderman has earned CSEA's support.»

Poor diet and a lack of physical activity are major contributors to the world's obesity epidemic, but researchers have also identified common environmental pollutants that could play a role.

And you also identify in the article a couple of other major developments that have contributed to the worldwide obesity epidemic.

Steve: And you also identify in the article a couple of other major developments that have contributed to the worldwide obesity epidemic.

Although 18th and 19th century archaeologists had discovered plenty of diseased remains at prehistoric sites in the Americas, they found no traces of the disease in European bones until a major epidemic hit Europe about 1500, just after Columbus returned from his 1493 voyage.

This suggests that a greater understanding of the mechanisms that drive inter-pandemic influenza epidemics may increase our capacity to predict the timing of major outbreaks associated with novel pandemic influenza viruses in the future.

American cities have gone through two other major crime epidemics in the last century one in the late 1960s into the early 1970s and another at the tail end of the 1980s into the early 1990s, when the nationwide murder rate hit an all - time high.

Crowley and Canzater identify five critical actions that should be priorities for monitoring HCV: 1) expand and standardize reporting to the CDC, 2) utilize electronic medical records to collect data on HCV cases and the cure cascade, 3) fund epidemiologic research using clinical data sets, 4) integrate improved monitoring of HCV with responses to the opioid epidemic, and 5) establish and monitor HCV elimination plans across major US health systems.

In addition to this, there was a drastic drop in the number of specimens in the 20th century due to its persecution, the destruction of its habitat, and two major viral epidemics suffered by the rabbit, its main food source.

More than two in three adults in the United States are considered overweight or obese, with substantial biomedical and clinical evidence suggesting that chronic overconsumption of a «western diet» — foods consisting high levels of sugars and fats — is a major cause of this epidemic.

Asia, for example, once had an epidemic driven mainly by sex work and injecting drug use, but heterosexual sex in China and Indonesia, each of which has enormous populations, now has become a major mode of transmission.

The results suggest that drugs capable of targeting similar molecular pathways in human fat cells could one day become major tools for fighting the growing worldwide epidemics of obesity and type 2 diabetes, according to senior investigator Shingo Kajimura, PhD, an assistant professor of cell and tissue biology in UCSF's School of Dentistry.

An epidemic of the deadliest form of plague, pneumonic, has hit major cities and towns in Madagascar and is spreading fast.

«The vast majority of scientifically collected data and analysis continues to support the case that the major driving factor for the African AIDS epidemic is sexual transmission,» he says.

«To my knowledge, there is only one really major historical case of a pneumonic plague epidemic, and that was in Manchuria in 1910,» he says.

A study published in Science [subscription required] in April mapped the virus's spread across the globe and found that every epidemic of the major strain of Influenza A since 2002 could be traced back to eastern and Southeast Asia.

But even if biology is a major driver of Russia's drug - resistant TB epidemic, public - health officials can still beat it back, says Dye.

«To rid the world of meningitis epidemics altogether, we need to go after all the major strains in one public health vaccine,» noted Adar Poonawalla, CEO and executive director of Serum Institute of India Private Ltd. «We are partnering with PATH on a pentavalent meningitis vaccine — targeting five meningitis strains, A, C, W, X, and Y — and will begin clinical trials this year.»

In a letter to the British Medical Journal, New Zealand researchers say the trend supports their argument that fenoterol, a drug used to relieve acute attacks, was a major factor in the epidemic of asthma deaths in the country in the 1980s.

Putting in the final piece of the puzzle, Sharp said the virus must have reached a major city to start the AIDS epidemic.

He often warns about the threat of epidemics and exotic mosquitoes; when the Asian bush mosquito (Aedes japonicus) showed up in the Netherlands, for instance, Knols said it might be able to transmit Zika, and, if so, a major door - to - door eradication effort would be called for.

The review, co-written by Dr. Tracey and Clifford S. Deutschman, professor of Anesthesiology and Critical Care at the University of Pennsylvania, notes that unlike other major epidemic illnesses, treatment for sepsis is nonspecific and limited primarily to support of organ function and administration of intravenous fluids, antibiotics and oxygen.

Up to 2014 wheat stem rust was not considered of major importance in Western Siberia, but severe epidemics in 2015 and 2016 has changed the situation.

Areas of focus include three major groups of human pathogens (Candida albicans, Cryptococcus neoformans, and the dimorphic fungi), obligate pathogens of diverse hosts (Microsporidia and Pneumocystis), and the wheat rust fungi (Puccinia sp) that cause current agricultural epidemics.

In the rare chance that an Olympic traveler catches Zika and exports the virus to another country with mosquitoes that could spread it around, Scott Weaver, a leading Zika specialist and the director of the Institute for Human Infections and Immunity at the University of Texas Medical Branch in Galveston, says there's likely little reason for worry: «It is likely that rates of human immunity in many other parts to the world that are permissive for circulation, such as tropical Africa and Asia, are already high enough to preclude major epidemics like we are seeing in the completely naive populations of the Americas.»

As a result C. difficile bacteria are now widespread in many hospitals and they are capable of causing major epidemics that are becoming increasingly frequent and severe.

Periodic outbreaks of the disease in sub-Saharan Africa, including an epidemic between 2013 and 2016, caused major loss of life and serious economic disruption in the three countries where it occurred: Sierra Leone, Guinea and Liberia.