Since HIV infection itself alters epigenetic processes in the immune system, the research team wondered whether a distinct DNA methylation profile,
a major epigenetic modification where methyl groups are added to DNA, occurs in those with HIV associated - cognitive impairment and whether it exists in distinct immune cell populations from the blood.
Not exact matches
The study found two
major events that wipe out, or reprogram,
epigenetic modifications.
The
major goals are to gain new knowledge into the ensemble of
epigenetic mechanisms including DNA methylation, non-coding RNAs and histone
modifications that are persistently altered by early experiences and how they are transmitted across generations.