Inclusion Criteria: Subjects must have histologically or cytologically confirmed metastatic cutaneous or mucosal melanoma, Able to swallow and retain orally administered medication, Adequate hematological, renal, hepatic, and coagulation laboratory assessments Exclusion Criteria: Clinically significant bleeding within 4 weeks of screening, Current use of warfarin, factor Xa inhibitors, and direct thrombin inhibitors, Infection requiring anti-infective treatments within 1 week of study enrollment, Anti-tumor therapy,
Major surgery within 28 days
• Subject has had
major surgery within 4 weeks prior to the first study dose.
Not exact matches
The
major risk associated with the
surgery itself is inadvertent damage to the parathyroid glands — these are small glands that lie close to, or
within, the thyroid glands themselves, and have a crucial role in maintaining stable blood calcium levels.
My 4 - year old American Bulldog, Mogli, recently had to undergo
major GI
surgery to remove a necrotic piece of his small intestine and part of his colon, after his small intestine became tangled
within his abdominal wall.
If you've not had
major surgery, you health is well controlled with medications or minor treatment, and your height to weight ratio (also called BMI) is
within reason, you may qualify.