In the case of several
major tumor types, the collagen matrix plays a critical role, Eliceiri says.
The Wnt pathway is known to be inappropriately activated in many
major tumor types, including colon, breast, liver, lung and pancreatic cancers, and is critical for the function of CSCs.
Not exact matches
Cancer stem cells, a
type of self - renewing cell found in
tumors, are of particular interest because they are the main cell
type responsible for
tumor progression and for resistance to chemotherapy and radiotherapy, and therefore a
major cause of
tumor recurrence after treatment.
A
major challenge in creating any
type of organoid is determining the unique mixture of nutrients, growth factors, and tissue culture techniques that will transform patient
tumor cells into miniature
tumor organoids in a petri dish.
A
major new insight is the realization that different
tumors of the same
type may rely on entirely different
tumor stem cell populations.
«But we know that
tumors generally develop from a single cell or a small number of cells of a specific cell
type, which is one of the
major determinants of the characteristics of
tumor cells,» explains postdoctoral researcher and co-author Dinorah Friedmann - Morvinski.
Around 700 individual
tumors representing 17
major cancer
types were characterized in the studies above.
This single - celled algae also increases the activity of Natural Killer (NK) cells, a
type of white blood cell that plays a
major role in host rejection of
tumors.