Sentences with phrase «major types of cells»

The pancreas is a flat, thin organ located in the front of the abdomen of the dog, near the stomach, that contains two major types of cells.

«If gdf3 is not supplied to the egg by the mother, the fertilized egg can not produce two of the three major types of cells required for development,» Burdine said.

Not exact matches

Each person's blood is one of four major types: A, B, AB, or O. Blood types are determined by the types of antigens on the blood cells.

Transplants of the cells might help some major types of anaemia

The service also allows for characterization of all major immune cell types and detects infiltrating immune cells.

Trials of cells made from human embryonic stem cells are also poised to begin in people with type 1 diabetes and heart failure, the first time embryonic stem cells have been used in the treatment of major lethal diseases.

This system plays a major role in the regulation of gene activity, and enables the selective expression of different functions in differentiated cell types.

In the second Cell paper, researchers collaborated with scientists at the University of Cambridge, McGill University in Canada and several UK and European institutions to explore the role that epigenetics plays in the development and function of three major human immune cell types: CD14 + monocytes, CD16 + neutrophils and naïve CD4 + T cells, from the genomes of 197 individuCell paper, researchers collaborated with scientists at the University of Cambridge, McGill University in Canada and several UK and European institutions to explore the role that epigenetics plays in the development and function of three major human immune cell types: CD14 + monocytes, CD16 + neutrophils and naïve CD4 + T cells, from the genomes of 197 individucell types: CD14 + monocytes, CD16 + neutrophils and naïve CD4 + T cells, from the genomes of 197 individuals.

Within this «optic cup», six major types of retinal cells were identified.

In 2008 the National Institutes of Health launched the $ 190 - million Roadmap Epigenomics Project with the goal of cataloguing the epigenetic marks in the major human cell types and tissues.

Another type of white blood cells — B cells or B lymphocytes — plays a major role in activating the autoreactive T cells (T lymphocytes) that then destroy the pancreatic beta cells leading to type 1 diabetes.

Inindividuals with albinism, genetic alterations interfere with the melanocytes» production of pigment or their ability to distribute it to keratinocytes, the major cell type of the skin's outer layer.

Building upon their earlier research on the biology of fat metabolism, Joslin scientists discovered that microRNAs - small RNA molecules that play important roles in regulation in many types of tissue — play a major role in the distribution and determination of fat cells and whole body metabolism.

The team established that an enzyme called LPCAT3 (Lysophosphatidylcholine acyltransferase 3) is involved in the biosynthesis of phosphatidylcholine (PC), a type of compound lipid that is a major component of cell membranes.

«We've shown that a specific type of these cells, known as follicular helper T (Tfh) cells are not only necessary, but are a limiting factor that differentiates between an average and a potent antibody response to HIV,» says Crotty, a scientific collaborator with the Center for HIV / AIDS Vaccine Immunology & Immunogen Discovery (CHAVI - ID), a major research consortium led by The Scripps Research Institute.

COUNTLESS research projects around the world into cancer and other major diseases are producing bogus or misleading results because investigators are studying the wrong type of cell.

«This is a major breakthrough and a beautiful example of convergent evolution where vertebrates at least five times have independently evolved» this ability «by modifying different cell types to serve the same function.»

The results suggest that drugs capable of targeting similar molecular pathways in human fat cells could one day become major tools for fighting the growing worldwide epidemics of obesity and type 2 diabetes, according to senior investigator Shingo Kajimura, PhD, an assistant professor of cell and tissue biology in UCSF's School of Dentistry.

Cancer stem cells, a type of self - renewing cell found in tumors, are of particular interest because they are the main cell type responsible for tumor progression and for resistance to chemotherapy and radiotherapy, and therefore a major cause of tumor recurrence after treatment.

The cells transformed into the six major types of retinal cells and spontaneously arranged themselves into a layered cup - like structure, mimicking the adult retina (Nature, DOI: 10.1038 / nature09941).

A major challenge in creating any type of organoid is determining the unique mixture of nutrients, growth factors, and tissue culture techniques that will transform patient tumor cells into miniature tumor organoids in a petri dish.

Calmodulin (CaM) is a major effector for the intracellular actions of Ca2 + in nearly all cell types.

Doctors have long figured that the major roadblock to recovery was the scar tissue formed by a type of glial cells called astrocytes.

The addition of a few nanometers of a thin layer of aluminum oxide protects a perovskite solar cell against humidity — still a major stumbling block to the commercial application of this new type of solar cell.

Experiments in three major types of biological organisms — human cells, algae, and fungi — found in each case that levels of magnesium in cells rise and fall in a daily cycle.

Several pieces of evidence suggest that B cells are major players in type 1 diabetes, Dr. Kissler says.

In contrast with most other reviews, it covers all major corneal cell types in a comprehensive way, showing similarities and differences in the healing process and the usage of stem cells for therapy.

Researchers at Joslin Diabetes Center now have pinpointed a major inflammatory role for «natural killer» (NK) immune cells in abdominal fat — a type of tissue strongly implicated in insulin resistance.

What is there — a spinal cord, all major regions of the brain, multiple cell types, signaling circuitry and even a retina — has the potential to dramatically accelerate the pace of neuroscience research, said Anand, also a professor of neuroscience.

«The ability to [match] the binding of the clam shell to the targeted cell type and use this as a trigger for delivery is a major step beyond the smart drugs of today.»

There are two major issues here: the differentiation of cells into a range of different types, and the assembly of cells into tissues, organs, and, ultimately, an intact organism.

Genodermatoses are characterized by genetic disorders of the skin affecting mainly either keratinocytes or melanocytes the two majors cell types of the epidermis.

natural killer (NK) cells - a type of cytotoxic lymphocyte that constitute a major component of the innate immune system.

The Polonis lab has also employed both cell line - based model systems, as well as primary cell types from uninfected humans, to investigate virus - antibody - host cell interactions and cross-subtype reactivities amongst the major subtypes of the HIV pandemic.

Endoderm cells are a type of cell found in the early embryo, and which eventually mature into the body's major organs — including the pancreas, the home of β - cells.

A major new insight is the realization that different tumors of the same type may rely on entirely different tumor stem cell populations.

«But we know that tumors generally develop from a single cell or a small number of cells of a specific cell type, which is one of the major determinants of the characteristics of tumor cells,» explains postdoctoral researcher and co-author Dinorah Friedmann - Morvinski.

In this effort, Dr. Zuniga made a major «hit» while a postdoctoral fellow at the Scripps Research Institute, when she initiated study into plasmacytoid dendritic cells, a subset of leukocytes that produce large quantities of the antiviral mediators type I interferons, and have significant developmental potential.

The team concluded that AIG1 and ADTRP, at least in the cell types tested, appear to work mainly to break down FAHFAs and not any other major class of lipid.

Endoderm cells are a type of cell found in the early embryo, and which eventually mature into the body's major organs — including the pancreas, the home of ß - cells.

Summary: University of Chicago researchers have developed the first practical method to limit activity of therapeutic genes to a specific cell type (smooth muscle cells), clearing a major safety hurdle facing gene therapy.

A major challenge that will be addressed in the second phase of LINCS is to optimize the combinations of cell types, perturbations and measurements of cellular responses to address a wider range of basic biological and disease - related problems than was possible in the program's initial pilot stage, said Alan Michelson, M.D., Ph.D., senior investigator, Laboratory of Developmental Systems Biology, NHLBI, and co-chair of the NIH LINCS Project Implementation Team.

The major gains in behavioral recovery and neuronal survival achieved by pre-differentiation of glial precursors to specific, beneficial astrocytic cell types prior to transplantation stresses the need to consider such manipulations as a critical component in the optimization of stem / precursor cell transplantation based therapies.

That these results held up not only in iPSCs, but also in cells derived from the stem cells showed that «CRISPRi holds a major advantage in making disease - relevant cell types,» coauthor Mohammad Mandegar of Gladstone said in the release.

Many of the novel motifs displayed occupancy patterns that were highly cell - type - specific, similar to the patterns observed among major developmental and tissue - specific regulators.

Scientific summary: Fibroblasts are the major mesenchymal cell type in connective tissue and deposit the collagen and elastic fibres of the extracellular matrix (ECM).

Small - cell lung cancer, or SCLC, is one of the 2 major types of lung cancer and accounts for 10 % to 15 % of all lung cancer cases.

Examining the genomic and epigenetic makeup of major types of immune cells from nearly 200 blood donors in the U.K., IHEC researchers found that genetics explain most of the epigenetic variation among individuals.

In the Drosophila testis, however, the whole system has been laid out, and stem cells can be readily identified — a major hurdle for most other types of stem cells.

Kidney cancer — also called renal cell cancer — is one of the major types of cancer for which new immune - based cancer treatments are currently in development.