The researchers believe this difference in B cell distribution among those with uncontrolled HIV adds to a list of reasons most people do not
make effective antibodies against the virus.
Not exact matches
Since cows are so good at
making broadly neutralizing
antibodies, it also might be possible to turn the cow's handiwork into drugs for HIV treatment, if bovine
antibodies are
effective at stopping the virus in other animals, he says.
Although the
antibody approach has been successful, it increases the risk of severe allergic reactions as well as the possibility that the patient's immune system will become sensitized, destroying the
antibodies and
making long - term treatment less
effective.
The researchers are now exploring additional proteins that could be added to the IL - 2 and
antibody combination to
make immunotherapy more
effective.
His research could help scientists develop more
effective vaccines and treatments for allergies and autoimmune diseases, which occur when our bodies
make antibodies wrong, and they end up attacking the body itself.
It would not be desirable in every case —
antibodies are more important in fighting some infections than others — but it potentially gives vaccine makers a new tool that could be used to
make vaccines more
effective.»
Currently, standard treatments consist of receiving FIX
made in animal cells (called recombinant), which is expensive to manufacture, must be administered several times per week and can trigger the development of immune
antibodies, rendering it less
effective over time.
So young pets need to be vaccinated several times during this period to
make sure that A: they're being protected as early as possible, and B: they are getting
effective antibody production around / after the loss of the maternal
antibodies.
Antibodies form in response to the Epogen injections however,
making repeated injections less and less
effective as the renal failure progresses.