When diseases like cancer and AIDS are impacting millions of people each year and rare but deadly infections like Ebola are moving faster than treatment, the race to
make effective drugs becomes a sprint.
Not exact matches
In the past few years companies like Braeburn Pharmaceuticals, Intarcia Therapeutics, and Proteus Digital Health have set out to create better medical mousetraps through devices that
make existing
drugs more
effective.
But a nonprofit is
making its own hepatitis C combination medication that it says is just as
effective as those created by for - profit
drug giants.
Regulatory authorities in the U.S. and Europe believe that real - world data can
make the
drug - development process more efficient and cost -
effective, as well as help better inform patients and physicians about the uses of new products.
«The current messages saying that bed sharing is dangerous only if you or your partner are smokers, have been drinking alcohol or taking
drugs that
make you drowsy, are very tired or the baby is premature or of low - birth weight, are not
effective,» the authors wrote in the study, adding that doctors need to «take a more definitive stance against bed sharing for babies under three months».
Drug companies used to stay one step ahead by continually introducing new medications, but bacteria have been mutating rapidly in response,
making the
drugs less
effective.
As
drug delivery via the lungs is generally more
effective than some other methods, says Peace, vaping could
make «already dangerous
drugs even more dangerous».
The trial of nusinersen was stopped in August when it became clear it was
effective,
making it unethical not to give the real
drug to those on the placebo.
«In fact, very little progress in finding more
effective drugs for epilepsy has been
made in the past 100 years.»
When administering SSRIs, the team saw that the
drug first collected in the lipid rafts, and afterward, the critical GαS protein moved out of the rafts, freeing it up and
making the protein more
effective.
These «designer» peptides could one day
make up a new class of therapeutic
drugs that is more
effective and results in fewer side effects.
Dr. McCabe said nanoparticles are a leading - edge technology also being studied for delivery of
drugs for other conditions, such as cancer, heart disease, and bacterial infections, in order to target specific cells to reduce toxicity and side effects of those medications and to
make them more
effective.
This could
make the
drug effective against autoimmune disease.
As a result, infectious disease experts currently try to find a balance between
making sure
drugs are
effective at knocking out harmful bacteria while keeping the treatment duration to the bare minimum required to stamp out an infection.
A panel of experts convened in 2007 by the prestigious Institute of Medicine estimated that «well below half» of the procedures doctors perform and the decisions they
make about surgeries,
drugs, and tests have been adequately investigated and shown to be
effective.
Since cows are so good at
making broadly neutralizing antibodies, it also might be possible to turn the cow's handiwork into
drugs for HIV treatment, if bovine antibodies are
effective at stopping the virus in other animals, he says.
«If we could load these virus shells with a different cargo, say a
drug, and target it to a particular place in the body, such as a tumor, it could then deliver the
drug to just that specific location,
making the
drug more
effective, or reducing side effects,» Lawrence said.
A blood pressure
drug may
make a type of lung cancer treatment more
effective, suggests a new study.
A key to the study is an understanding that using two, three or more antibiotics in combination does not necessarily
make the
drugs more
effective in combating bacteria — in fact, in many cases, their effectiveness is actually reduced when
drugs are used together — so the combinations must be chosen carefully and systematically.
To
make a compound work better against a specific disease target, medicinal chemists optimize the
drug, tweaking its structure or physical properties to
make it more
effective and safer.
«If we really want to
make a difference,» Khatri said, «our test has to be more cost -
effective than the
drug itself.»
With the help of the diamonds, the
drug stayed in the bloodstream 10 times longer than usual,
making it much more
effective.
Neural machine translation has been a latecomer to the game of deep learning, a method of
making predictions about everything from
effective marketing pitches to potential
drug candidates.
Achim Harder, head of anthelmintic research at Bayer, the German company that
makes praziquantel, says it is not clear why the
drug is less
effective in Senegal.
So Charlotte Willans from the University of Leeds, UK, and colleagues subjected silver to the same treatment as platinum to see if they could
make an
effective cancer
drug.
They suggest that the frequent questioning of these
drugs in media is unjustified and may
make depressed patients refrain from
effective treatment.
Poirier hopes that with further funding and support, his studies will lead to the development of
drugs targeted to specific genotypes,
making them safer and more
effective and reducing side effects.
What's more, the women in both the heparin and control groups also received injections of the
drug for 42 days after birth, potentially helping to protect them against blood clots that may manifest themselves at that point, but possibly diluting the results —
making it appear that heparin was not as
effective as it may have been.
In addition, «since no animal models of fibromyalgia exist, our model provides a much - needed tool for understanding what
makes current fibromyalgia
drugs efficacious and for finding more
effective drugs,» the researchers wrote.
A: Yea, it's possible it could lead to that, but we need to recognize that these are
effective drugs in treating short - term pain in particular, and we need to
make sure there is an opportunity for people with pain to have opioids as part of their treatment.
«We hope to get initiatives like this all over the subcontinent, and they could all join together, and that would put pressure on the national governments to
make the
drug bans more
effective,» says Chris Bowden, the Bangaluru, India — based program manager for Saving Asia's Vultures from Extinction, a consortium of conservation groups and government agencies.
To
make things worse, no antiviral
drugs currently available have proven
effective against it, and because scientists do not know where the virus resides between outbreaks, environmental control is impossible.
Current antimalarial
drugs are becoming less
effective as the parasite develops resistance to the
drugs,
making the search for new targets that can kill all species of malaria critical.
To stop hepatitis C, any
effective drug also had to incorporate itself into the virus's genetic code, where it would need to halt the virus's ability to
make new copies of its genes and thus to
make new virus.
Sentinel will treat the consumer market like one giant observational study to
make sure the
drugs are as safe and
effective as believed.
This molecule plays an important role in some cancers and
drugs that block it are already available to patients — but
making drugs that are more
effective and less damaging to healthy cells could lead to patients living longer and reduce side effects.»
«Not only is this new pathway exciting from a discovery perspective, it could ameliorate some of the side effects of cancer and cardiovascular
drugs to
make them safer and more
effective.»
As a result, Shaw's team has begun another clinical trial with a more potent ALK inhibitor — LDK378, a
drug made by Novartis — that might take over when Xalkori becomes less
effective.
«Our research adds weight to the idea that
effective antifungal
drugs can target even those mitochondrial proteins that are highly conserved in humans and fungi, and that this could be a way to
make a broad spectrum antifungal combination therapy that would be less susceptible to resistance,» says Benjamin Vincent, a former graduate student in Whitehead Member Susan Lindquist's lab who is now a scientist at Yumanity Therapeutics.
Or it could be that chance just happened to
make drug A appear more
effective in that trial.
One
effective approach is to deliver
drugs made from small molecules of ribonucleic acid, or RNA, which are used to inhibit gene expression.
The
drug works by inhibiting replication of the hepatitis C virus; researchers noted that both hepatitis C and Zika belong to the same viral family and bore strong structural similarities that could
make sofosbuvir
effective against the latter.
As nanotechnology to ferry
drugs to their destinations is tested in both the laboratory and in clinical trials, scientists have
made a surprising discovery about the kinds of nanoparticles that might be most
effective for eventually transporting a number of different cancer - fighting therapies throughout the body.
These compounds can
make drugs more selective,
effective, or potent.
Recently a series of
drug recalls have pulled back the curtain to show how the media, the public, and some doctors can misinterpret medical studies or take them out of context in ways that
make medical treatments look safer and more
effective than they actually are.
Painkillers were not much better, and the most
effective drugs made your patient exhausted and constipated.
When we go to the doctor, we assume that the
drugs he or she prescribes have been carefully tested to
make sure they are both safe and
effective.
Discovering the structure of this enzyme will provide valuable insight into how this protein functions and could provide blueprints for designing
drugs that inhibit or increase certain protein functions, which would
make those
drugs more
effective.»
Highly dependent on their estrogen receptors for growth and survival, these tumor cells are sensitive to hormonal therapies,
making drugs like tamoxifen and fulvestrant
effective first - line therapies for many patients.
A new method has been developed to
make drugs «smarter» using nanotechnology so they will be more
effective at reaching their target.