Sentences with phrase «make precise changes»

CRISPR - Cas9 is an experimental gene editing technique used to make precise changes in DNA.

The specificity of this DNA cutting activity has made CRISPR - Cas the darling of gene therapy researchers, who have modified it to make precise changes in the genomes of cultured cells, laboratory animals, and even humans.

CRISPR — Cas9 (or CRISPR, for short) has given scientists a powerful way to make precise changes to DNA — in microbes, plants, mice, dogs and even in human cells.

For nearly five years, researchers have been wielding the molecular scissors known as CRISPR / Cas9 to make precise changes in animals» DNA.

Make some precise changes, with this in mind, and you'll start to see the benefits, guaranteed.

Yet CRISPR, he notes, «is less efficient at making precise changes.»

In lab cultures of human and yeast cells, the scientists stopped the harmful clumping of FUS proteins by exposing them to phosphorylation, a process that makes precise changes to the amino acid building blocks of proteins, increasing their negative electric charge.

Not exact matches

I know it doesn't seem like a huge change to make if you're used to it, but it can be hard to switch over to measuring in a whole new way and it can be tough to make sure the measurements are exact in grams / ounces (at least in my experience — for instance I keep having to spoon out extra flour out of the bowl if I added too much... it definitely takes a learning curve to be precise).

So, I'll just say a little more about why yeast; which is, over the decades, yeast molecular biologists have devised so many powerful tools that allow you to make very precise changes in yeast, in their DNA; exquisite control, where you can change a single base that you want in a particular place, you can put a whole gene in, take a whole gene out, swap genes etc..

Farren Isaacs of Yale University led the team that this week proves it is possible to make numerous and very precise changes in the genome of living cells.

Walker and Ritchie were part of a project at the Roslin Institute and spin - off PPL Therapeutics, aiming to make precise genetic changes to farm animals.

EdF has not made public the precise changes it wants to make at Mochovce, but Morris Rosen, an assistant director - general of the International Atomic Energy Agency, which has approved the plans, says the modifications will centre on improving the reactors» control and monitoring systems.

The development of efficient and reliable ways to make precise, targeted changes to the genome of living cells is a long - standing goal for biomedical researchers.

Dr. Zhang then turned to genome editing strategies, whereby precise changes to an organism's DNA can be made.

ROB STEIN, BYLINE: Scientists have recently developed powerful new techniques that let them make very precise changes in DNA.

Now that we've determined that an element of our school needs a change and we've framed the ideal situation as a goal, it's time to make a list of precise strategies and try one out.

The EPAS changes give it better feel and feedback and make it feel more precise and better off - center.

It's not only tight around the gate, but precise and intuitive and within three or four shifts your left hand drops instinctively to go up and down the ratios, no longer do you need to make a conscious effort to change gear and be prepared to wrestle it home.

Further making this Alfa Romeo an extension of the driver are rev - matching paddle shifts and precise gear changes as quick as 130 milliseconds at full throttle.

With a steering that's light and precise, it seems eager to change directions, but a little more steering feedback would have made this saloon more involving to drive.

Usually with a 1.6 litre engine you would think the only way to make sure desired progress was not impeded would be through precise gear changes.

And if lane changing might be child play for experienced drivers, it is now the same for the brain of the Mercedes limousine, after no less than 5,000 autonomous such tests, to make sure the Active Lane Change Assist works as precise as the Swiss watches.

The chassis feels very well balanced, and direction change is quick and precise, making it very nimble.

Adopted from the current 911 Turbo and the track - prepped 911 GT3, the steering system makes the Carrera more precise when changing lanes at higher speeds, while also ensuring greater maneuverability in city traffic thanks to a turning radius that is 1.6 feet smaller.

Precise adjustments were made to the lamps» curved profile, with each change evaluated and verified in wind tunnel and real - world driving tests.

The coupe's precise and nicely weighted electric rack - and - pinion steering tracks true with good feedback, making abrupt lane changes and sudden, tight curves a delight.

It is probably best to keep working with the neurologist as it is often possible to make a more precise diagnosis with time, as the symptoms change and the response to medications can be assessed.

I'm really confused, and we need to know the precise history of when the individual MBH98 records were posted, and when the various matlab format files were posted, and in response to what requests, and these latest changes that were made on Oct 29, 2003??

Hansen actually made some more precise predictions on various emissions scenarios and what the resulting temperature changes would be.

While the UN Intergovernmental Panel on Climate Change findings make clear that future climate policy will be needed to significantly reduce emissions, the timing of the precise policy measures that will implement those reductions remain unclear.

And perhaps rather than trying to formulate precise plans in terms of personal consumption or make radical immediate changes, its better to just get things pointing in the right general direction.

Limited availability of data and a variety of uncertainties relating to future changes in climate, social and economic conditions, and the responses that will be made to address those changes, frustrate precise cost and economic loss inventories.

Gaps in records from the last century and other issues make it difficult to be precise about the relative influences at this stage, but climate change is expected to dominate in the future.4

To point out just a couple of things: — oceans warming slower (or cooling slower) than lands on long - time trends is absolutely normal, because water is more difficult both to warm or to cool (I mean, we require both a bigger heat flow and more time); at the contrary, I see as a non-sense theory (made by some serrist, but don't know who) that oceans are storing up heat, and that suddenly they will release such heat as a positive feedback: or the water warms than no heat can be considered ad «stored» (we have no phase change inside oceans, so no latent heat) or oceans begin to release heat but in the same time they have to cool (because they are losing heat); so, I don't feel strange that in last years land temperatures for some series (NCDC and GISS) can be heating up while oceans are slightly cooling, but I feel strange that they are heating up so much to reverse global trend from slightly negative / stable to slightly positive; but, in the end, all this is not an evidence that lands» warming is led by UHI (but, this effect, I would not exclude it from having a small part in temperature trends for some regional area, but just small); both because, as writtend, it is normal to have waters warming slower than lands, and because lands» temperatures are often measured in a not so precise way (despite they continue to give us a global uncertainity in TT values which is barely the instrumental's one)-- but, to point out, HadCRU and MSU of last years (I mean always 2002 - 2006) follow much better waters» temperatures trend; — metropolis and larger cities temperature trends actually show an increase in UHI effect, but I think the sites are few, and the covered area is very small worldwide, so the global effect is very poor (but it still can be sensible for regional effects); but I would not run out a small warming trend for airport measurements due mainly to three things: increasing jet planes traffic, enlarging airports (then more buildings and more asphalt — if you follow motor sports, or simply live in a town / city, you will know how easy they get very warmer than air during day, and how much it can slow night - time cooling) and overall having airports nearer to cities (if not becoming an area inside the city after some decade of hurban growth, e.g. Milan - Linate); — I found no point about UHI in towns and villages; you will tell me they are not large cities; but, in comparison with 20-40-60 years ago when they were «countryside», many small towns and villages have become part of larger hurban areas (at least in Europe and Asia) so examining just larger cities would not be enough in my opinion to get a full view of UHI effect (still remembering that it has a small global effect: we can say many matters are due to UHI instead of GW, maybe even that a small part of measured GW is due to UHI, and that GW measurements are not so precise to make us able to make good analisyses and predictions, but not that GW is due to UHI).

Precise predictions of hurricane tracks and intensity; heavy rain; severe storms; fire weather; air quality and chemistry, and climate change address societal challenges that include disaster mitigation, economic decision making, health concerns, travel and workplace safety, long range planning, and day to day decisions (an umbrella or a heavy coat, for example).

The language that gets changed in the body is not changing the science; it's changing the descriptions of the science in a draft that has been edited, re-edited, re-edited, and re-edited to make sure the conclusions in the text are every bit as precise as the carefully considered summary.

Measurements from spacecraft avoid this problem, and the most precise of these, made continuously since 1979 (Fig. 2a, b), have revealed changes on all time scales — from minutes to decades — including a pronounced cycle of roughly eleven years.

Or to be perhaps even more precise, isn't the right test between stations where virtually no man - made changes have happened within a radius where they might affect a temperature change versus those where man - made changes have occurred?

1950s: Research on military applications of radar and infrared radiation promotes advances in radiative transfer theory and measurements = > Radiation math — Studies conducted largely for military applications give accurate values of infrared absorption by gases = > CO2 greenhouse — Nuclear physicists and chemists develop Carbon - 14 analysis, useful for dating ancient climate changes = > Carbon dates, for detecting carbon from fossil fuels in the atmosphere, and for measuring the rate of ocean turnover = > CO2 greenhouse — Development of digital computers affects many fields including the calculation of radiation transfer in the atmosphere = > Radiation math, and makes it possible to model weather processes = > Models (GCMs)-- Geological studies of polar wandering help provoke Ewing - Donn model of ice ages = > Simple models — Improvements in infrared instrumentation (mainly for industrial processes) allow very precise measurements of atmospheric CO2 = > CO2 greenhouse.

But now, to make sense of the precise link between greenhouse gases and climate change, researchers must first understand in much greater detail how the oceans and the land absorb atmospheric carbon, and in what quantities.

In contrast to frequently made statements, Bm is not necessarily a more precise indicator of climate change than is glacier length.

The judge questioned the expert on the precise changes he made as a result of those discussions and concluded the changes were significant.

Making change and keeping precise till.