All
this makes resistance genes a uniquely troubling sort of pollution.
Not exact matches
This
makes me happy: a research project has identified a
gene that gives wheat plants
resistance to one of the most deadly races of the wheat stem rust pathogen, Ug99.
Bacteria
make up about one - third of the solid matter in human stool, and Scott Weber, of the State University of New York at Buffalo, studies what happens to the antibiotic
resistance genes our nation flushes down its toilets.
Bacteriophages, or viruses that infect bacterial pathogens, may also act as vectors of virulence or of antibiotic
resistance genes, ultimately
making bacterial disease worse for the host.
Weber predicts that follow - up studies will show the
resistance genes have indeed
made the jump to sludge bacteria.
Sidney Altman and his colleagues at Yale University used one of the bacteria's own enzymes, called RNase P, to disable RNA
made from
genes that had been linked to drug
resistance.
Women with high levels of FGF1 were less likely to respond to platinum - based drugs, but blocking the
gene makes their cells lose their
resistance (British Journal of Cancer, DOI: 10.1038 / bjc.2012.410).
Nor would they be able to receive any
genes from natural bacteria that would endow them with antibiotic
resistance or the ability to
make toxins.
The first transgenic crop likely to be put forward for approval for open trials and commercial release is Bt cotton — which has added
genes from the Bacillus thuringiensis bacterium,
making the plant produce toxins that confer
resistance to some insect pests.
All that has to happen is the
genes that
make her be choosier about this have to survive better till the next generation by showing up in babies that survive better because their
resistance is perfect.
The
gene for colistin
resistance can be easily spread to other bacteria,
making it likely that colistin
resistance will become widespread in the future.»
«Plants with one type of glyphosate -
resistance mechanism
make multiple copies of the target site for glyphosate, a
gene called EPSPS.
«We
make (genetic) crosses to incorporate the right
genes needed for
resistance.»
Still, the qualities that
make it easier for certain bacteria to pick up the
resistance gene, and other
genes that enhance that one's performance, are unclear, the researchers report in the 1 March issue of Lancet Infectious Diseases.
To find out if their guess was right, Levin, Schrag, and Perrot
made some of the drug - resistant bugs susceptible again by replacing their
resistance gene with a
gene that conferred sensitivity.
The
genes encoding NDM - 1 and other antibiotic
resistance factors are usually carried on plasmids — circular strands of DNA separate from the bacterial genome —
making it easier for them to spread through populations.
Hyperthermophilic composting, therefore, has the potential to
make composting end products safer by reducing the abundance of unwanted antibiotic
resistance genes.
The researchers, led by Dr Charles Wondji, used a wide range of methods to narrow down how the
resistance works, finding a single mutation in the GSTe2
gene, which
makes insects break down DDT so it's no longer toxic.
That background
makes it important to characterize «both the natural occurrence of the antibiotic -
resistance genes and the anthropogenic load, and where those
genes come from, and it's good to do it in a quantitative way,» as Pruden's team did for the South Platte, says Joakim Larsson of the University of Gothenburg, Sweden, who has tracked antibiotics and
resistance genes in India and Sweden.
With a human strain showing widespread
resistance as well — and the fact that pandemic viruses may arise when avian and human strains swap
genes —
makes it even less appealing, says Bright.
Companies selling Bt seeds hope to avoid that in part by designing plants that
make more than one Bt toxin, but this strategy may not work if
resistance to several toxins is tied to a single
gene, says Tabashnik, who is now at the University of Arizona.
In one instance, he
made the memory especially easy to read by engineering the cells to mutate an antibiotic
resistance gene in response to light.
A few years later, O'Neill and others
made a startling discovery: They didn't even need to couple Wolbachia to infection
resistance genes.
Dr Melita Gordon, from the University of Liverpool's Institute of Infection and Global Health, said: «Importantly, the antibiotic
resistance genes, which have previously been carried on a separate genetic package, have now been incorporated into the main chromosome of the bacteria itself, which is likely to
make it easier for the Typhoid strain to retain these
resistance genes.»
They successfully pinpointed the exact spot in the chromosomal structure that is home to the
genes which
makes it drug - resistant, known as an antibiotic
resistance island.
«The greatest hope for achieving durable
resistance to rust diseases is to
make wheat's
resistance genetically complex, combining several
genes and
resistance mechanisms,» Singh explained.
Extremely precise genome - editing techniques such as CRISPR / Cas9 now
make it possible to adjust the
genes of endangered species toward better
resistance to exotic diseases, or to modify the
genes of invasive species to reduce their ability to reproduce.
Earlier cases of
resistance were largely due to mutations in single
genes — trump cards that immediately
made for invincible parasites.
The pair work together to develop detection methods for new and emerging tomato viruses, identify the tomato
genes responsible for virus
resistance, and
make this information available to plant breeders.
Using CRISPR, researchers can select hardier wild rice varieties that require less fertilizer or have a natural pest
resistance, and turn off the one «seed shattering»
gene that has
made them undesirable to growers.
The availability of molecular markers for these
genes, which help breeders improve the accuracy and speed of developing new varieties, has
made improving
resistance to bacterial blight more efficient.
The statistical analysis of
gene - families,
resistance genes and mobile elements was performed by ShotgunFunctionalizeR 1.03 using custom -
made annotations and the Poisson model for direct comparisons [24].
One use of these
genes might be to insert them into other crop plants to provide «disease
resistance, or to
make them grow bigger and faster,» says Kaul.