Sentences with phrase «making machinery of the cell»

MicroRNAs lower the levels of proteins such as BDNF by binding to messenger RNA, the molecular middleman that carries instructions from genes to the protein - making machinery of the cell, and tagging it for destruction.

The goal of these drugs is to, in various ways, destroy this message, denying the protein making machinery of the cell the instructions for making a specific protein.

Not exact matches

Only whole cells may contain all the necessary machinery for self - reproduction... Not only is DNA incapable of making copies of itself, aided or unaided, but it is incapable of «making» anything else... The proteins of the cell are made from other proteins, and without that protein - forming machinery nothing can be made.»

Ataluren appears to persuade the machinery of the cell to «run» that stop sign and allow a functioning protein to be made.

Another interesting aspect to the work is that it demonstrates the possibility of adding new machinery to human cells to enable them to make therapeutic agents in response to disease signals.»

He and colleagues have determined what gives cholera bacteria their curved shape and whether it matters (a polymer protein, and it does matter; the curve makes it easier for cholera to cause disease), how different wavelengths of light affect movement of photosynthetic bacteria (red and green wavelengths encourage movement; blue light stops the microbes in their tracks), how bacteria coordinate cell division machinery and how photosynthetic bacteria's growth changes in light and dark.

One big one: «Not everybody appreciates the way CRISPR technology works — it makes the cut in the DNA but it doesn't take care of the repair — so we rely on the cells» fundamental machinery to do that,» Doudna says.

Once inside cells, they are taken up by cellular protein - making machinery and induce the production, over weeks, of the viral proteins they encode.

During this time, transcription — the conversion of gene «recipes» encoded in DNA to mRNA, the messenger that carries the recipe to the cell's protein - making machinery — is completely shut off.

Given the potential for living systems to produce highly complex chemical compounds, researchers working with Michelle C.Y. Chang at the University of California, Berkeley (USA), aimed to manipulate the biosynthetic machinery in cells to use simple fluorinated building blocks to make new organofluorine target molecules.

They seem most lifelike only when they invade and co-opt the machinery of living cells in order to make more of themselves, often killing their hosts in the process.

When EBOV makes copies of itself inside cells, it does so by taking over and hijacking parts of that host cell's basic machinery to make its own proteins.

Since the beginning of time, viruses have been inserting their genetic material into the genomes of their hosts, tricking the cell's machinery into making more virus.

HIV - 1 integrates its own genome into the genome of human immune system cells known as CD4 + T cells, hijacking their cellular machinery to make more copies of itself.

At the heart of the «bit» of memory is essentially a fragment of DNA called a promoter, which enables the machinery of a cell to make a given protein.

When a methyl group (a carbon atom with three hydrogen atoms attached) binds to a cytosine molecule (one of the four nucleotides that make up DNA), it tells the cell's transcription machinery not to transcribe that gene.

Theoretically, once a particular codon — say, TAG — has been removed from a genome, the cell's protein - making machinery could be reprogrammed to assign TAG to an amino acid, instead of being a stop signal.

But when physiologist H. Lee Sweeney of the University of Pennsylvania School of Medicine in Philadelphia and his colleagues put this faulty gene into embryonic quail muscle cells growing in lab dishes, the cells made a shortened version of the protein and incorporated it into their contractile machinery.

One of the paper's co-authors, Hugh Willison, who studies GBS at the University of Glasgow in Scotland, says it's possible that something more subtle is happening: Like other viruses, the one that causes Zika hijacks a cell's own replication machinery to make new copies of itself, which then break out of the dying cell and infect neighboring cells.

The phages infiltrate bacterial cells, where they commandeer the host machinery to make thousands of new phages; then they escape through the bacterial cell wall — killing the host — and spread to infect their next victims.

A member of the U.S.S.R. Academy of Sciences shares his model of how cells recover from blows to their protein - making machinery

Researchers applied the findings to a mouse model with a genetic mutation in a component of the ribosome — the machinery that makes proteins — and the rate of protein production was reduced in stem cells by 30 percent.

October 21, 1994 Immortalizing agent of tumor cells found in yeast Researchers at the University of Chicago Medical Center have isolated the gene for a component of the elusive molecular machinery that plays a key role in making cancer cells immortal.

Basically, the cell's protein - making machinery reads a sequence of DNA as a sentence composed entirely of three - letter words called codons.

Importantly, while the enhanced presence of Bcl - xL is expected to promote cancer cell survival in the first place, it may also indicate that the apoptotic machinery (especially the caspases) are still in place, making it necessary for the tumor cell to maintain a high level of Bcl - xL [10].

Researchers at the University of Chicago Medical Center have isolated the gene for a component of the elusive molecular machinery that plays a key role in making cancer cells immortal, offering scientists a tantalizing target for new anticancer drugs of greater effectiveness and lower toxicity.

Cells from mice bred in Singh's lab to lack PU.1 allowed the researchers to manipulate the cells» decision - making machinery by introducing different amounts of Cells from mice bred in Singh's lab to lack PU.1 allowed the researchers to manipulate the cells» decision - making machinery by introducing different amounts of cells» decision - making machinery by introducing different amounts of PU.1.

During the ensuing infection, it makes many copies of its genetic material, using the cell's machinery, and this reassembles into many more virus particles that are then released to infect more cells.

Lindquist's group focused on a yeast protein called sup35, part of the normal yeast machinery for making all the other proteins in the cell.

Once stuck, the drug tells the cell's own machinery to dispose of the message molecule, so the protein isn't made.

The researchers are currently using the 4D microscope to image the components of cells, such as proteins and ribosomes, the cellular machinery that makes proteins.

«Lymphocytes are the white blood cells that help make antibodies and are part of the normal infection - fighting machinery,» Dr. Nichols explains.

The real kicker for muscle growth is that your body is a fine piece of machinery, and to better prepare itself for future metabolic stress, it adapts by adding cells to the muscle fibers which makes them bigger and stronger.

Large amounts of any PUFA, moreover, will cause the cell to make less of this enzymatic machinery by convincing the cell that it is no longer needed.26 This competition and cellular confusion can be avoided altogether by providing small amounts of preformed arachidonic acid and DHA in the diet.