To
make a monoclonal antibody — a class of biologic drug that, while perhaps not as well known as the influenza vaccine or insulin (two other kinds of biologics), is highly prevalent — scientists start by inserting a gene into a cell that will enable it to produce a desired protein.
The high specificity with one epitope target
makes our monoclonal antibodies very efficient, reflecting in less background staining and low cross-reactivity with other proteins.
In terms of
making the monoclonal line: I had never done it before and it worked the first time probably because I used a robust cell line.
Not exact matches
The researchers, who were funded by Leukemia & Lymphoma Research and Cancer Research UK, have shown that some cancer cells are able to draw
monoclonal antibodies inside themselves,
making them invisible to immune cells.
Targeted drugs
made from engineered immune proteins — called
monoclonal antibodies — have revolutionised treatment for several types of cancer in recent years.
Made by Mapp Biopharmaceutical of San Diego, California, ZMapp contains three
monoclonal antibodies produced in tobacco plants.
Here we report the use of a liposomal vaccine for the generation of a
monoclonal antibody with particular characteristics that
makes it a valuable tool for fundamental studies as well as a candidate antibody for diagnostic and therapeutic applications.
Made major contributions to the field of immunology through his studies on immune tolerance in animal models, with particular focus on transplantation tolerance and autoimmunity, in addition to pioneering the use of therapeutic
monoclonal antibodies against T cells, resulting in the development of Campath - 1H, the first humanised
monoclonal antibody to be used therapeutically.
Monoclonal antibodies are one such class of biologics and these drugs are
made by farming antibodies from B cells that will act against a specific part of the disease process.
Our RabMAb ® technology is a patented hybridoma - based technology for
making rabbit
monoclonal antibodies.
His choices widened when he looked at the work of his graduate school mentor, who had
made important contributions to society by founding a Cord Blood Bank, and of a professor at a local 2 - year college, who advanced student training in scientific research by involving them in the lab production of
monoclonal antibodies.
It is a
monoclonal antibody against IL - 31, a cytokine that
makes dogs itch!