Sentences with phrase «making tumor cells»

These modifications contribute to a tumor's ability to grow indefinitely, as well as making tumor cells drug resistant and capable of surviving treatments intended to kill them.

«What we may be looking at,» he adds, «is a future way to prevent metastasis to many organs simultaneously» using drugs that make tumor cells let go of the blood vessels they cling to.

«Therefore, inhibiting NF - kB will might make tumor cells more vulnerable to elimination by the immune system.»

The new study revealed that pancreatic cancer cells not only send signals that make macrophages produce abnormal amounts of dectin - 1 surface receptors, but also that make tumor cells themselves express high levels of galectin - 9.

Nguyen is developing ways to guide surgeons during tumor removal surgery by using fluorescent compounds to make tumor cells — and just tumor cells — glow during surgery, which helps surgeons perform successful operations and get more of the cancer out of the body.

Not exact matches

Delano said a previous doctor told him the bump was a lipoma — a harmless tumor made of fat cells.

As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?

This makes me happy: Microglia cells migrate into tumors and supply cancer cells with a substance needed for the repair of DNA damage.

Prior to the development of a fully functioning nervous system, and the activation of said system, a human embryo is «alive» in the same sense a tumor is «alive»: the individual cells that make it up are alive, but there is no higher - level functionality.

You need to stop immediately on the side with the tumor, in case rogue cancer cells make it into your daughter's body, and then gradually stop on the other side.»

Introducing human prostate cancer cell lines into mice, Wu and his colleagues saw a particular enzyme called MAOA activate a cascade of signals that made it easier for tumor cells to invade and grow in bone.

A successful test would therefore require isolating enough of these scarce cells to make statistically valid inferences about the tumor, often at a stage when the tumor itself is growing and changing rapidly.

A route used by tumor cells to spread could be exploited to make stem cells for regenerative medicine and cancer therapies

Opioids also may make blood vessels leaky, making tissues more receptive to cancer cells looking for places to build a tumor, Moss says.

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

T cells genetically engineered to make the chimeric antigen receptor can recognize and target tumor cells.

These might make a cell hardier in a foreign environment — say, when a breast cell relocates to bone — or more able to escape the primary tumor and survive while rushed through the bloodstream.

The personalized vaccine is made from patients» own immune cells, which are exposed in the laboratory to the contents of the patients» tumor cells, and then injected into the patients to initiate a wider immune response.

But, counter-intuitively, this mass cell death might be the very thing that makes the animals so long - lived: it could be a natural mechanism their bodies use to clear precancerous cells, stopping tumors in their tracks.

In mice with pancreatic tumors, Kalbasi and other members of the team found relatively high levels of inflammatory compounds including CCL2, the signaling molecule that activates CCR2 on monocytes and macrophages to make these cells migrate to tumors.

Using tumor samples from a patient, they do lab tests to determine which substances can first make the different types of cancer cells uniform and then effectively kill them.

The team has given the new protein a name: HAMLET for Human Alpha - lactalbumin Made LEthal to Tumor cells (appropriate for a Scandinavian hero that alters its nature to take lethal action).

Ruggero has for several years been probing the ability of tumor cells to make extraordinary amounts of protein to sustain their rapid growth and immortality.

In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia Agostinis.

«Our study sought to understand what happens to make those growth - plate cartilage cells remain, and this work will ultimately be used to determine what causes those benign tumors to become malignant.»

The initial experiments made use of cancer cells that Quiñones - Hinojosa and his team removed from willing patients and grew in the laboratory until they formed little spheres of cells, termed oncospheres, likely to be the most resistant to chemotherapy and radiation, and capable of creating new tumors.

Scientists at Barrow Neurological Institute have recently made discoveries about use of a new technology for imaging brain tumors in the operating room — a finding that could have important implications for identifying and locating invading cells at the edge of a brain tumor.

«One of the major and immediate downstream effects of myc activation is a dramatic increase in the capacity of affected cells to make protein,» Ruggero said «This, in turn, leads to increased cell survival and proliferation, and to unstable genomes that foster additional mutations that turn these abnormal cells into tumor cells.»

A team of researchers led by Julie Y. Djeu, Ph.D., associate center director of education and training at Moffitt, discovered that TGF - β produced by tumor cells causes NK cells to make high levels of a molecule called microRNA - 183 (miR - 183).

There are as many as 14, but the scientists found that cyclin D adds just a single phosphate at one, and only one, of the 14 locations during the early G1 phase of cell cycle progression, essentially make 14 different versions of the Rb tumor suppressor.

A mutation that helps make cells immortal is critical to the development of a tumor, but new research at the University of California, Berkeley suggests that becoming immortal is a more complicated process than originally thought.

To make the vaccine, cancer cells are harvested from a tumor after surgery and stripped of their proteins; then those proteins are cultured with dendritic cells, a subclass of white blood cells, drawn from the patient's blood.

«Our test should make it possible to find drug combinations that kill ALL the cancerous cells in a tumor,» Skala said.

If metastatic cancers are most often made up of cells with different genetic drivers, perhaps researchers should be targeting the primary tumor with multiple drugs to contain the cancer.

Metastasis, or cancer spread by the formation of tumors at new sites, is generally what makes cancers deadly because surgery and other treatments are unlikely to find and destroy every cancer cell.

CCL5 attracts tumor cells to the lungs and lymph nodes, and VEGF increases the number of blood vessels and makes them more porous, allowing tumor cells to metastasize and infiltrate the lungs.

For tumors to grow and spread, cancer cells must make larger than normal amounts of nucleic acids and protein, so they can replicate themselves.

Glioblastoma is the most lethal form of primary brain tumor and leads to death in patients by invading the brain tissue in a process that allows single cells to move through normal brain tissue, which makes complete surgical removal of the tumor impossible.

So making cells in the primary tumor softer might be a way to prevent metastasis,» he said.

«We believe the cells lacking myoferlin are made softer in the tumor so they can't physically detach away.

The cells also might react by making fewer receptors, which may make the prostate tumor cells vulnerable once more to androgen deprivation therapy.

The stem cell model says that tumor growth is more hierarchical, mainly driven by a subset of cells that can make new copies of themselves and give rise to the other cell types the tumor contains.

Treating the smoldering embers that surround the tumor rather than just mutant cells could make cancer a disease we can live with.

«Beta blockers may lead to new novel triple negative breast cancer treatments: New research suggests that adrenaline can act on tumor cells via a cell surface receptor called the beta2 - adrenoceptor and that changes in signaling within the cell make it highly invasive.»

Researchers are creating organoids from tumor cells to mimic cancers and introducing specific mutations into organoids made from healthy tissue to study how cancer arises.

The authors said their results, which they have made publicly available, constitute an invaluable resource to help clinicians predict which chemotherapies will be most effective against tumor cells with particular genetic mutations, and how to rationally combine therapies to prevent cancers from developing resistance.

«The finding that certain cell signaling lipids change the activity of an oncogenic Ras protein, suggests that we might be able to interfere with tumor progression by inhibiting the enzymes which make the specific cell signaling lipid in cells,» Buck said.

However, tumors are made up of a variety of different cell types, and it has been unclear whether photodynamic detection identifies all of them.

Although other tumor suppressors exist, what makes Par - 4 so special is that it is not mutated as frequently as other known suppressors, and it's «selective» in its actions in that Par - 4 will only kill cancer cells and not normal cells.

Genetically modified Salmonella bacteria target tumors and make the immune system extra aggressive toward cancer cells.