Sentences with phrase «making unintended»

At the risk of making an unintended pun, we are not embroidering here.

But what if it were to end up making unintended changes to other parts of the genome that aren't targeted?

Should you make an unintended blunder, it will prove hard to take back.

The tool isn't perfect — it can, on occasion, make unintended cuts or replacements in a cell's DNA, which could lead to severe health problems for the recipient.

Charles Pfahl's favorite piece Archetype presents a subtle shift of color, which may make unintended references -LSB-...]

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

As we've seen countless times over the years, tax reforms always come with unintended consequences that only emerge once tax payers have had some time to digest the new rules, adjust their reporting accordingly, and start making the tweaks and refinements that will help them maximize profit and minimize tax.

Again, the issue of deficit reduction is unlikely to register very much in the debate about whether or not it is appropriate to require women to register for the draft — but it makes for an interesting example of just how far the unintended consequences of a piece of legislation can reach.

Section 831 of the law (entitled «Closure of Unintended Loopholes») made several changes to the Social Security Act and closed two complex loopholes that were used primarily by married couples.

This episode is a perfect example: an unintended casualty of this weekend's firestorm is the idea of data portability: I have argued that social networks like Facebook should make it trivial to export your network; it seems far more likely that most social networks will respond to this Cambridge Analytica scandal by locking down data even further.

Most tech was made with good intentions; only later do the unintended consequences become clear.

I know it is either the unintended consequences of decisions made in some ivory bank tower or just a dog scratching fleas.

«Government intervention can have unintended consequences that could make matters worse for certain stakeholders.»

The vulnerability of phone numbers is the unintended consequence of a broad push in the security industry to institute a practice, known as two - factor authentication, that is supposed to help make accounts more secure.

To the extent that the proposed rules make it more difficult for multinational companies to reduce US taxable profits, however, there could be a negative effect on foreign direct investment as an unintended consequence.

By respecting equally the life of the unborn child and the life of the mother, by supporting notification and consent before an abortion involving a minor, by offering ministries to reduce unintended pregnancy, by affirming (and encouraging church support of) crisis pregnancy centers, and by urging family counsel in decision - making about abortion, the additional language is decisively pro-life.

If An American Bible shows the unintended mess that Protestants made of the Bible's significance, In Discordance with the Scriptures details the ways that Protestant churchmen over the last 125 years have tried to put the genie of a vernacular Bible back in the bottle of one version that all Protestants would use.

I think there are, however, good arguments to be made from the natural sciences, which I believe can help us discern unintended consequences of our decisions including the decision at hand.

Richard, yes I think it can be considered «unfair» when using the «rules» to gain an unintended advantage, i.e. intentionally dropping the ball... just because both sides can take advantage of the same loophole does not make the situation fair.

Yet McCain - Feingold had the unintended effect of making 501 (c)(4) political activities far more important than they had been, since the law's ban on soft money doesn't apply to such groups...

Even the commonplace pieties we repeat to one another that never make it to Facebook can get all twisted up with unintended implications wherever they are uttered.

«So let's work together to reduce the number of women seeking abortions by reducing unintended pregnancies, and making adoption more available, and providing care and support for women who do carry their child to term,» Obama said to applause.

I think that this premium might end up becoming further enticing to a new or unintended target of Chinese consumers that enjoys making large ticket purchases at the aim of being a status symbol or «showing off» their wealth.

«Tourist destinations across the country are often threatened by mega-chain hotels, restaurants, and grocery stores, because they have the unintended effect of wiping away so much of what makes a community unique,» stated Paul Menta, co-owner of Key West Legal Rum and Executive Chef at The Stoned Crab.

We make no guarantees about the accuracy, currency, content or quality of the information provided by such third - party sites, and we assume no responsibility for unintended, objectionable, inaccurate, misleading, or unlawful content that may reside on those sites.

But besides the unintended humor of the trophy, O'Hara didn't think the series made any waves.

Breastfeeding Answers Made Simple — Breastfeeding Reporter — Unintended Consequences «By emphasizing how to create a safe sleeping environment — rather than trying to browbeat parents into avoiding bedsharing — more babies» lives would be spared.

Infant deaths that occurred as a result of bed sharing under these circumstances have resulted in health authorities such as the American Academy of Pediatrics recommending that parents not sleep with their infants.6 It is ironic that not only does blanket condemnation of bed sharing potentially make parenting unnecessarily more difficult for some mothers, it also has the unintended outcome of increasing deaths in places other than beds, such as sofas.

These 10 child discipline mistakes that fathers make can produce unintended results and create barriers to your children's future good behavior.

But critics say campaigns like these are fueling an unintended side effect: making new mothers more stressed out than ever.

But the country's terrain, the fractured nature of Malian politics, and the unintended consequences that always flow from the use of force, all make this intervention a risky proposition.

That action guidance of IL mitigates unintended consequences and makes it easier for an actor to align right intent (comply with law) with an acceptable compromise between interests and norms.

They have not been properly thought through and could end up making a mess of education provision through their unintended consequences.

Unintended consequences are a fact of life, but to make policy in wilful ignorance of them is not only disheartening but is nothing short of dangerous.

And it offers grist to both ideological conservatives and liberals.For conservatives and libertarians, the tragedy reveals the deleterious blowback of nanny state intervention.The social welfare and family court judge tilted to the missing wife's parents, and restricted Josh's visits from his two sons.We should expect Gingrich to run with this story, attacking the liberal nanny state; and how this liberal state's actions have negative unintended consequences.Liberals will also weigh in.The police, 911 distpatcher, and the criminal justice systemas a whole, all failed.The «hard power» of the police state actually made matters worse.As the ideological divide plays out, the tragedy does not end.The young mother / wife is still missing, and presumed dead.The sick Josh is no longer a person of interest.

But one unintended consequence might be that while districts are focused on making sure they stay within the cap, many are actually spending more.

I vaguely had a project in mind, to try to write some sort of political equivalent of Freakonomics... Something about the law of unintended consequences in political decision - making, and how some problems, especially social ones, just get dumped, almost by default, in certain places.

Gary Ashton, Director of Firearms Operations at BASC said: «BASC is confident that the government supports British shooting and wishes to see it prosper, nevertheless it is important that any changes made during the passage of the Bill through parliament do not have adverse or unintended consequences.

«But we're also equally accepting that there's also an issue about how you do that so you make sure you don't create unintended consequences where, say, a family with one earner gets child benefit removal when there's another family with income earners who actually collectively earn more but keep the benefit.»

A cap with no other change makes no sense for the city, you'll just have another class of unintended consequences.»

But we still have to see the specifics and make sure there are no unintended consequences.»

«The current law creates an unintended incentive to find every way to jack up the rent — jack up the rent to get it out of rent regulation; create vacancies to get it out of rent regulation; make quote - unquote «capital improvements» so that the rent can be jacked up more to get it out of rent regulation,» he said.

«But we also continue to challenge those who make the laws to ensure that any changes are based on sound evidence and do not have unintended consequences.

But we also have to make sure there are no unintended consequences.»

The Committee makes clear that this breach of the rules on my part was unintended.

This small measure actually has been proven to reduce rates of unintended pregnancy by up to 30 percent; it makes a big difference people with jobs, school, or who live in a rural community far from a pharmacy.

Sensible, educated solutions the government is pursuing, making healthy rooms for growth and unintended improvement.

I think any legislator who is thorough and is thoughtful of whatever unintended consequences come out has to make sure that the words make sense.»

The researchers used two types of Cpf1 family proteins (AsCpf1 and LbCpf) as they are the most efficient among its kind and performed Digenome - seq: A test they devised to identify intended (on - target) and unintended (off - target) sites the researchers wanted Cpf1 to make a cut throughout the genome.

Many people have concerns about the possible use of genome editing in humans, for example, about the risks of unintended effects due to off target DNA alterations, and the implications of making irreversible changes that will be passed on to future generations.