Furthermore, by
making use of embryonic stem cells and in vitro differentiation, SIF - seq can be used to assess enhancer activity in a wide variety of disease - relevant cell types.»
Not exact matches
To
make the HSCs, the Harvard group
used human skin
cells to create induced pluripotent
stem cells (iPSCs), adult
cells researchers genetically reprogram to an
embryonic -
stem -
cell state, where they can grow into any kind
of cell.
Trials
of cells made from human
embryonic stem cells are also poised to begin in people with type 1 diabetes and heart failure, the first time
embryonic stem cells have been
used in the treatment
of major lethal diseases.
But the factor that may
make the discovery very significant is that umbilical cord blood can be saved, stored and multiplied without any
of the ethical dilemmas facing
embryonic stem cell use, which are derived from human fetuses.
The act
of reprogramming
cells to
make them as capable as ones from embryos apparently can result in aberrant
cells that age and die abnormally, suggesting there is a long way to go to prove such
cells are really like
embryonic stem cells and can find
use in therapies.
ERRORS have occurred in a type
of stem cell that could be
used instead
of embryonic stem cells — and in tissues
made from them.
The immediate payoff was a commercialization deal in age - related macular degeneration in which Pfizer became the first big pharma company to
make a move into the
use of embryonic stem cells as the basis for a tissue regeneration therapy.
«
Use of induced pluripotent
stem cell (iPSC) technology» — which involves taking skin
cells from patients and reprogramming them into
embryonic - like
stem cells capable
of turning into other specific
cell types relevant for studying a particular disease — «
makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie
of KU Leuven.
After many delays, the first FDA - approved experiment in people
of a therapy
made using human
embryonic stem cells began in October.
Recently, his lab
used induced pluripotent
stem (iPS)
cells — adult
cells made to act like
embryonic stem cells —
made from skin
cells of patients carrying apoE4, or other mutations related to Alzheimer's, to study their effects on the development, survival, and degeneration
of human neurons.
Even though different
cell types were
used as the initial starting materials, and they were
made to produce different sets
of proteins, both groups identified and isolated
cells nearly identical to human
embryonic stem cells, and did so in the same timeframe.
Teitell
used embryonic stem cell lines that
made different types
of neurons and studied them with array CGH for comparison.
For instance, MEF
cells are usually
made of fibroblasts from the mouse embryos at
embryonic day 13.5 and only
cells at early passages (p2 to p3) are
used as feeders for derivation and culture
of embryonic stem (ES) and iPS
cells.
Their promise was so great that when President Obama announced last March that he was lifting the ban on the
use of federal money for research on human
embryonic stem cells, critics on the right were apoplectic: iPS
cells, they said,
made such a move scientifically unjustified.
And meanwhile, university researchers can and do work on
embryonic stem cells — just so long as they don't
use federal funds (which
makes for some complicated partitioning
of lab equipment in many a US university department).