Sentences with phrase «making use of mice»

Making use of mice bred for developing Alzheimer's like symptoms, the researchers provide evidence that caffeinated coffee protects against the disease which isn't possible with other beverages that contain caffeine or decaffeinated coffee.

To address this question, the researchers made use of mice with mutations that affect different aspects of synapse unsilencing.

Apple iPhone users can pair their device with a Bluetooth wireless keyboard, but they won't be able to make use of a mouse as iOS doesn't support them.

Not exact matches

If you've used an Apple mouse (IDEO fashioned the company's first, in 1980), swept with a Procter & Gamble (PG) Swiffer (it collaborated on the hit), or even stood in line at an airport recently (the firm has worked with the Transportation Security Administration to make the process friendlier), you've felt the legacy of David Kelley.

Ghosh tried plugging a regular mouse into his laptop, but the lack of big - enough surfaces on the road and during presentations made it cumbersome to use.

Well, that's more in honour of my grandmother who also used to make «mice» cookies, except she didn't shape hers as neatly as my mother did.

Not only can these Mickey Mouse Stickers make the perfect reward system when used as potty stickers and teamed with one of our FREE Potty Training Charts, but they can also be added to a potty chair to make a decorative statement!

Check out PalinAsPresident.com, a great use of Flash to present a satirical view of Sarah Palin occupying the Oval Office — make sure your sound is on and just start mousing over things.

«In our attempt to make CBT friendly, JAMB introduced the use of 8 keys without a mouse.

A year before he published his results in 2017, research by a team in Japan led to the birth of live mouse pups using eggs the team made from adult skin cells.

The experiment also showed that mouse brains are flexible enough to receive and make use of the additional wavelength information.

For the first time, researchers have made something resembling a mouse embryo without using an egg cell, allowing them to probe the early steps of development

We generated knockout mice lacking synaptobrevin / VAMP 2, the vesicular SNARE protein responsible for synaptic vesicle fusion in forebrain synapses, to make use of the exquisite temporal resolution of electrophysiology in measuring fusion.

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

Senior author Madhav Dhodapkar, M.D., the Arthur H. and Isabel Bunker Professor of Medicine and Immunobiology, and chief of Hematology, said the study, using tissue and blood samples from humans and mice, shows that chronic stimulation of the immune system by lipids made in the context of inflammation underlies the origins of at least a third of all myeloma cases.

The researchers used mice with skin like that of red - haired, fair - skinned people, who don't tan because of a nonfunctioning protein on the surface of the skin cells that make melanin.

Scientists made select nerve cells in mice's brains sensitive to light, and then used lasers to activate specific groups of those cells.

To make their discovery, Iragavarapu's team used two groups of mice, one of which was genetically modified so it could not produce the CHI3L1 glycoprotein.

The results obtained by Afsaneh Gaillard's team and that Pierre Vanderhaeghen at the Institute of Interdisciplinary Research in Human and Molecular Biology show, for the first time, using mice, that pluripotent stem cells differentiated into cortical neurons make it possible to reestablish damaged adult cortical circuits, both neuroanatomically and functionally.

In a paper published Sept. 21 in Cell, Harvard Medical School genetics professor Olivier Pourquié — whose lab discovered the segmentation clock 20 years ago — and colleagues report that they used mouse cells to reconstitute a stable version of this clockwork for the first time in a petri dish, leading to several new discoveries about where the clock is located, what makes it tick and how the vertebral column takes shape.

Hay's team also showed that the same approach could be used to make female mice generate antibodies to the zona pellucida, a layer of proteins that surrounds egg cells.

For over two decades, consumers have used the internet to research, shop, make friends, find dates and learn about the world with the click of a mouse or a few keystrokes.

Morgan Fullerton, lead author of the study, added: «Unlike the majority of studies using genetic mouse models, we haven't deleted an entire protein; we have only made a very minor genetic mutation, equivalent to what might be seen in humans, thus highlighting the very precise way metformin lowers blood sugar in Type 2 Diabetes»

To make their discovery, Hasko; and colleagues used two groups of mice.

Using a tiny colonoscope, Quirós and Cruz - Acuña delivered the hydrogel, along with the organoids, into wounds that had been made in the intestines of immune - compromised mice.

What's more, the technology works not just for humans but for almost any higher species and is being used to make high - resolution maps of mice, rats, various plants, and even sheep, goats and pigs.

It highlighted differences in the structure and make up of human NMJs compared with those of mice and rats, which are routinely used in studying neuromuscular diseases.

In the study, the scientists used a type of mouse, called CVN - AD, that they had created several years ago by swapping out a handful of important genes to make the animal's immune system more similar to a human's.

Using a model of Parkinson's disease in which the toxin MPTP, made famous in book «The Case of the Frozen Addicts,» induces Parkinson's - like symptoms in humans and mice, Dr. Smeyne showed that mice infected with H1N1, even long after the initial infection, had more severe Parkinson's symptoms than those who had not been infected with the flu.

Using mice fed on a fat - rich diet that made them overweight and raised their blood sugar levels, they found that a daily dose of kynurenic acid stopped the mice putting on weight and gave them better glucose tolerance, despite no change in their food intake.

In one test for working memory — the ability to use recent experience to make decisions — the mice were trained to find food in one arm of a maze based on a visual cue.

In an elegant proof - of - principle approach, the researchers used synthetic molecules to decrease the physical distance between the ER and mitochondria in cells and in liver tissue and found that this intervention impaired mitochondrial function and made mice more sensitive to high fat diet - induced insulin resistance and diabetes.

He used adult cells — first in mice, although the technique is now feasible in human cells — to make stem cells that can form a wide range of other cells, essentially turning their cellular clocks back to infancy so they could mature into different adults.

A compound used in many common plastic products, including baby bottles and dental sealants, causes genetic abnormalities in mice, say researchers who made the discovery as a result of a mix - up in the lab.

Using a drug made from three mouse antibodies, the researchers said it protected two out of four non-human primates that were given the treatment two days after infection.

With the combined use of genetics and pharmacology, the investigators altered the production of proteins controlled by eIF2α in adult mice, essentially converting them into adolescents by making them more susceptible to cocaine - induced changes in synaptic strength and behavior.

Using a new class of mathematical models that do not make many assumptions about how behavior is organized, we will deconstruct the mouse's normal behavior into motifs, or syllables, and correlate those with brain activity.

Aerosol administration was performed as follows, the residual cup was filled with 8mls of the cisplatin agent and the nebulisation time was 10 minutes (almost 1 ml / minute) as observed from our previous studies.14 The aerosol was delivered to the mice (one by one) within a nose only cage that has been previously presented.34 In the groups receiving the intratumoral cisplatin an insulin injection was used to deliver the 2mls of cisplatin within the tumor in different depths, however; a quantity of the drug when the injection was made superficially was lost since it was not accumulated.

The George lab has made seminal contributions to the field including: discovering a novel population of neurons in the brain of humans, rats and mice that are involved in nicotine dependence, identifying neuronal ensembles responsible for nicotine and alcohol addiction, and unveiled the cellular and molecular changes associates with long term use of nicotine, cocaine, methamphetamine and alcohol use on the brain.

To better understand this complex tissues and its functions — and the diseases that affect it — a multicenter team led by researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital has released a census of the cells that make up the lining of the small intestine, using gene expression profiles of more than 53,000 individual cells from the mouse gut or gut organoid models.

They are also investigating the use of a natural gene drive system in mice to ensure to ensure that all of the non-native mice on an infested island can be reached and made nonreproductive.

Südhof then made use of the emerging power of mouse genetics to delineate the functional role of a number of these vesicle proteins including the role of synaptotagmin, which he demonstrated to be the critical calcium sensor for rapid neurotransmitter release.

Researchers have produced vast libraries of short segments of ribonucleic acid (RNA) that can be used to turn off individual human and mouse genes to study their function.The libraries will be made...

It will make use of cutting - edge approaches in vivo and in vitro, including mouse genetic models and next - generation sequencing of RNA and immunoprecipitated chromatin (RNA - seq and ChIP - seq).

For instance, MEF cells are usually made of fibroblasts from the mouse embryos at embryonic day 13.5 and only cells at early passages (p2 to p3) are used as feeders for derivation and culture of embryonic stem (ES) and iPS cells.

In fact, in the same issue of PNAS, a team from the Massachusetts Institute of Technology and University of California, Irvine report success in preventing gut infections by vaccinating mice against Salmonella using siderophores made by those bacteria.

We used Rag1 - / - mouse splenocytes, a source of ILC3s, because the absence of T cells in this model makes ILC3s the dominant IL -22-expressing cell type [40].

These webtools make use of the multilayered datasets from the BXD mouse population to expedite in silico gene function prediction through a series of integrative and complimentary systems analytical approaches, including (expression - based) phenome - wide association, transcriptome - / proteome - wide association, and (reverse --RRB- mediation analysis.

The webtools make use of the multilayered datasets from the BXD mouse population to expedite in silico gene function prediction through a series of integrative and complimentary systems analytical approaches, including (expression - based) phenome - wide association, transcriptome - / proteome - wide association, and (reverse --RRB- mediation analysis (Figure 1 - 2).

In 2009, a group led by Brian Kaspar of Ohio State University published a paper, also in Nature Biotechnology, showing that an AAV strain called AAV9 injected into the bloodstream could make its way into the brain — but it was only efficient when used in neonatal, or infant, mice.