Not exact matches
Small populations of adult stem
cells with somewhat limited developmental potential are responsible for the body's ability to heal injuries and replace worn out
cells and tissues, and evidence is growing that rare cancer stem
cells are responsible for the uncontrolled growth of some
malignant tumors, including
glioblastoma.
A research team led by Christine Brown, Ph.D., and a clinical team headed by Behnam Badie, M.D., has received a $ 12.8 million grant from the CIRM to fund a phase 1 chimeric antigen receptor (CAR) T
cell trial targeting an aggressive brain cancer called
malignant glioma, which includes
glioblastoma.
A phase 1 trial of a dendritic
cell (DC) vaccine administered with imiquimod, a TLR7 agonist that stimulates the innate immune system, for patients with
malignant glioma and
glioblastoma (NCT01808820).