Sentences with phrase «malignant growth of these cells»

An adenocarcinoma is a malignant growth of these cells most often originating (primary site) from the intestines, uterus and mammary glands.

Not exact matches

Breast cancer is the uncontrollable growth of malignant cells in the breasts.

Small populations of adult stem cells with somewhat limited developmental potential are responsible for the body's ability to heal injuries and replace worn out cells and tissues, and evidence is growing that rare cancer stem cells are responsible for the uncontrolled growth of some malignant tumors, including glioblastoma.

The Campàs lab is studying several of these questions, including how limbs are built and how mechanical changes in tumors affect the behavior of malignant cells and the growth of the tumor.

But the researchers also found that the new molecule intervened directly in the growth of the cancer itself, inhibiting a protein that controls the division and proliferation of malignant cells.

Nearly half of all cancer patients receive radiation therapy to curb the growth of malignant cells.

By providing a woman's family history of these cancers, including the ages they were diagnosed, the programs calculate a probability that the patient carries a harmful mutation in BRCA1 or BRCA2 (genes involved in controlling malignant cell growth).

Scientists now know that what matters most in determining the behavior of a particular cancer (and its response to specific therapy) are the molecular pathways that drive malignant cell growth instead of where the tumor begins in the body.

Therefore, the insights of Dr. Melendez and her colleagues may deepen our understanding of cancer and aid in the development of therapies against malignant cell growth.

As a result, the researchers were able to prevent the growth and malignant spread of the cancer in the animal model and human melanoma cells.

This rapid, malignant metastatic formation of melanoma, was previously put down to the high mutation rate that is characteristic of melanoma, i.e. genetic changes that stimulate the growth of cancer cells.

The growth of pNET malignant cells is closely tied to a cellular pathway known as mTOR (mammalian target of rapamycin).

Furthermore, since malignant cells exploit early developmental programmes for their survival and growth, a deeper understanding of human development will have impact in cancer research.

Anna Huttenlocher, University of Wisconsin, USA Neutrophils in the Tumor Microenvironment Neutrophils, Wounds, and Cancer Progression Stefan Kaufmann, Max Planck Institute, Germany Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells Kathryn Moore, New York University, USA MicroRNA -33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment in disease?

«Tumor stem cells can be considered to be the replicative engine of the malignant process, in other words, the cellular pool that continuously nourishes tumor growth.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Her goal is to define the molecular architecture and functional significance of a niche, determine how tumor growth impacts the niche, learn how benign and malignant cells compete within a niche, and use this knowledge to design precisely targeted anti-cancer treatments that spare normal bone marrow and improve the efficacy of stem cell - based therapies.

Role of Interferon -LCB- alpha -RCB-(IFN -LCB- alpha -RCB--RRB-- inducible Schlafen - 5 in Regulation of Anchorage - independent Growth and Invasion of Malignant Melanoma Cells

Lauric Acid inhibited the viability of both cancer cell types without altering the growth of MCF - 10A normal breast epithelial cells, thus suggesting its specific potential to trigger antiproliferative effects in malignant cells.

Although a non - essential amino acid in normal cells, the demand for glutamine is dramatically increased throughout malignant transformation to support increased metabolic demands; namely, provision of catabolic substrates for ATP production and anabolic substrates for macromolecule biosynthesis.The intracellular glutamine pool is also critical for sustained activation of mTORC1 signalling, a master regulator of cell growth and protein translation, as well as prevention of apoptosis

Phytoestrogens After Breast Cancer Endocr Relat Cancer 2001 (Jun); 8 (2): 129 — 134 In breast cancer survivors, most physicians avoid HRT because of concern regarding the potential promotion of growth of occult malignant cells by estrogens, due to the estrogen dependence of breast cancer.

Cancer information and prevention with ellagic acid Cancer: a malignant neoplastic disease -(any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream).

Published in the recent issue of the journal Cell Metabolism, new data points to adrenalin levels produced by exercise as the key to thwarting malignant growth.

Ammonia is toxic to normal colonic cells and stimulates the growth of malignant cells (Visek, 1978).

While there are many different types of cancer, all of them stem from the abnormal growth of cells that invade numerous body sites, quickly leading to the formation of tumours that are either benign (restricted to a local area and removable) or malignant (invasive, spreading throughout the body).

It's suspected that the hormones promote cellular growth, which then increases the number of cells that may be susceptible to malignant transformation.

a malignant growth made up of epithelial cells tending to infiltrate surrounding tissues and gives rise to metastases (spreading).

Blocking Hemangiosarcoma Tumor Growth Hemangiosarcoma, a malignant cancer of blood vessel cells, is an aggressive disease that is rapidly fatal in dogs.

We do not know the precise cause of malignant cancers of bones in dogs but abnormal bone cell growth and unusual hormone stimulation may be involved.

Rather, it is believed that hormones, through their promotion of cellular growth, increase the number of cells that may be susceptible to malignant transformation.

Early spaying may therefore, reduce occurrence of malignant lesions because the procedure removes the source of the hormones that cause some mammary cells to lose growth control, which puts these dividing cells at high risk for mutation and malignant transformation by environmental carcinogens.In fact, recent reports have identified activation of a specific oncogene in a number of canine mammary tumors.

Leukemia is a progressive, malignant disease that involves out - of - control growth of white blood cells (leukocytes) in a dog's blood and bone marrow.

Acupuncture may effectively reduce pain in cats with cancer and may also eliminate swelling or other symptoms that are associated with the growth of malignant cells in felines with cancer.

Skin tumors are the most commonly diagnosed neoplasms in veterinary medicine.2 These neoplasms represent a diverse group of benign and malignant growths arising from a variety of cell types.