This had been impossible in the past because, unlike
mammalian egg cells which are tiny and transclucent, a bird's egg cell is filled with opaque yolk and it is huge — this means that finding the nucleus is like looking for a white marble in a pool of milk.
The results help fill in the scientific puzzle kicked off by Dolly's cloning, which proved that
mammalian egg cells were capable of dissolving the genetic roadblocks that limit the potential of most adult cells to give rise to only a single type of tissue — that of the organ from which they hail — whereas embryonic stem cells have the potential to become virtually any kind of body tissue.
Not exact matches
It was 1996 when biologists first fused a
mammalian skin
cell with an
egg cell, cloning Dolly the sheep.
Harvard Medical School reproductive biologist Jonathan Tilly made headlines in March when he suggested
mammalian ovaries contain stem
cells that give rise to new potential
eggs, or oocytes, throughout adulthood.
The acquisition of so much cellular material from its sisters almost certainly helps the
egg start a program of growth through which it becomes the largest
cell in the
mammalian body.
He notes that the new study is especially relevant because it worked in
mammalian cells, which ultimately are a better way to grow the virus than
eggs: It's a faster production system and avoids mutations that occur when the virus adapts to chicken
eggs, which can compromise vaccine effectiveness.
Dr. Reinholdt's research focuses on comparative and functional
mammalian genomics, reproductive development and stem
cell biology.Researches gamete development, which gives rise to
eggs and sperm and supports early embryo development, with a focus on
mammalian reproduction and fertility.
The reason CRISPR is so controversial is that it works well on
mammalian «germline»
cells, such as sperm,
eggs and embryonic
cells, and the genetic editing can therefore result in heritable traits.