Not exact matches
Growth and development of the
mammary tissues begins at around weeks three and four of gestation, with specific
ductal branching and lobular formation.
Secretion of the hormones estrogen and progesterone set the stage for dramatic changes that take place in the breast during pregnancy: a massive proliferation of
mammary epithelial cells, and the formation of thousands of
ductal structures, which support milk production and transport during lactation.
When BPTF is knocked out in mouse
mammary stem cells early in pregnancy, however, there is a drastic decline in the number
ductal structures (right side).
Most often, breast cancer arises from the
mammary ducts (
ductal) or milk - producing lobules (lobular), though other less common histology types were represented as well.
This period is characterized by rapid
ductal growth and active proliferative activity of the
mammary epithelium of Lob 1.