Sentences with phrase «mammary gland cell»

Wilmut and his colleagues transplanted a nucleus from a mammary gland cell of a Finn Dorsett sheep into the enucleated egg of a Scottish blackface ewe.

The four Finn Dorsets were derived from the mammary gland cell line that led to the birth of Dolly.

In response to hormones circulating during pregnancy, DNA in mammary gland cells loses certain marks called methyl groups, the team found.

Mechanical Interactions of Mouse Mammary Gland Cells with a Three - Dimensional Matrix Construct.

Not exact matches

The mammary glands and milk - producing cells also help regulate how much of what you eat and drink actually reaches your baby through your milk.

Oxytocin contracts the cells in the mammary glands to push milk out of the nipple and into your baby's mouth.

These growth modulators are produced either by the epithelial cells of the mammary gland or by activated macrophages, lymphocytes (mainly T cells), or neutrophils in the milk.

The basic unit of the mammary gland is the alveolus or acinus cell that connects to a ductule.

One way, the drugs or medications can get into breast milk is to pass through the cell pores in the mammary gland.

The second way is to pass across the fatty cell membrane of the mammary gland.

Different studies suggest that bacteria present in the maternal gut could reach the mammary gland during late pregnancy and lactation through a mechanism involving gut immune cells.

In a study published in Cell Reports, researchers lead by Cédric Blanpain, MD / PhD, WELBIO investigator and Professor at the Université libre de Bruxelles, Belgium, identified a novel lineage - restricted stem cell in the mammary glCell Reports, researchers lead by Cédric Blanpain, MD / PhD, WELBIO investigator and Professor at the Université libre de Bruxelles, Belgium, identified a novel lineage - restricted stem cell in the mammary glcell in the mammary gland.

«Perhaps there are some mammary gland stem cells that can be coaxed to have a slightly broader potential than normal, but I very much doubt that embryonic - like cells normally exist in the breast,» says Robin Lovell - Badge of the National Institute for Medical Research in London.

In previous studies, the research team, headed by Pier Paolo Di Fiore and Salvatore Pece, investigated the role of a protein called Numb in maintaining stem cells in normal mammary gland development in mice.

In mammary gland stem cells, for example, Numb binds and inhibits an enzyme called Mdm2, preventing it from targeting p53 for degradation.

The study builds on Polyak's earlier research finding that women already identified as having a high risk of developing cancer — namely those with a mutation called BRCA1 or BRCA2 — or women who did not give birth before their 30s had a higher number of mammary gland progenitor cells.

A new technique — called DNA Programmed Assembly of Cells — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hCells — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hcells each, which can be built in a matter of hours.

The new technique — called DNA Programmed Assembly of Cells (DPAC) and reported in the journal Nature Methods on August 31, 2015 — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hCells (DPAC) and reported in the journal Nature Methods on August 31, 2015 — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hcells each, which can be built in a matter of hours.

Not only does this let them build up complex tissue components like the mammary gland, but also to experiment with specifically adding in a single cell with a known cancer mutation to different parts of the organoid to observe its effects.

But studying how the cells of complex tissues like the mammary gland self - organize, make decisions as groups, and break down in disease has been a challenge to researchers.

After a first pregnancy, milk - producing mammary glands remain in a state of preparedness, ready to quickly spring into action and feed subsequent babies, Camila dos Santos of Cold Spring Harbor Laboratory in New York and colleagues write May 19 in Cell Reports.

After isolating a mammary stem cell from mouse breast tissue, molecular biologist Jane Visvader and oncologist Geoffrey Lindeman of the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, managed to grow a functional breast, complete with milk - producing glands and ducts.

The authors believe theirs is the first study to show that mouse mammary gland tissues are sensitive to a mixture of 23 commonly used UOG chemicals, with dose - specific effects on tissue morphology, cell proliferation and induction of intraductal hyperplasias, an overgrowth of cells considered a marker for future breast cancer risk.

The first success came in 2006 when researchers created mammary glands after discovering mammary stem cells in mice.

«One of the least understood aspects of this process is how the excess milk and large numbers of dead cells are removed from the mammary gland without substantial activation of the immune system,» says Matthew Naylor, a cancer biologist at the University of Sydney in Australia.

Different tumor subtypes can include glandular, which include the mammary glands, as well as squamous, which are very rare and involve epithelial cells that line the inside of the breast.

«The mammary gland has a huge amount of stuff that it has to get rid of quickly after lactation, but if you just have immune cells taking the dead cells out, you still get chronic inflammation and tissue damage,» says Charles Streuli, who supervised the study.

But we had no other cell line to go with, so we all agreed that we'd use these mammary - gland cells and just see what happened, gain some experience.

The basic components of the mammary gland are the alveoli (hollow cavities, a few millimetres large) lined with milk - secreting cuboidal cells and surrounded by myoepithelial cells.

In Nrk mutant mammary glands, dense clusters of ER alpha - positive mammary epithelial cells were sometimes observed at late stages of pregnancy, which may represent the «bud» of the breast tumor.

During pregnancy, the elevated blood estrogen level induces the proliferation of mammary epithelial cells, leading to the development of the mammary gland in preparation for lactation.

Those hormones may subsequently enter the maternal bloodstream and affect milk - producing cells in the mammary gland, the researchers said in a Jan. 22 statement.

They removed epithelial cells from the fourth mammary gland of each mouse, leaving behind the stromal tissue.

Epithelial cells remove apoptotic epithelial cells during post-lactation involution of the mouse mammary gland.

However, we have found a system that allows the isolation of stem cells from the mammary gland and the investigation of their molecular features: with this knowledge in our hands we will be able to start the discovery of selective drugs capable of killing the stem cells of a given tumor.

An adult cell from the mammary gland of a Finn - Dorset ewe acted as the nuclear donor; it was fused with an enucleated egg from a Scottish Blackface ewe, which acted as the cytoplasmic (or egg) donor.

«They were thinking of the fact that the cell used came from a mammary gland and arrived at Dolly Parton, the credit is theirs.»

Title: Developmental stage - specific contribution of LGR5 + cells to basal and luminal epithelial lineages in the postnatal mammary gland Authors: de Visser KE, Ciampricotti M, Michalak EM, Wei - Min Tan D, Speksnijder EN, Hau C - S, Clevers H, Barker N, Jonkers J Date: 2012 Publication Details: The Journal of Pathology 2011 May; 224 (1): 56 - 66

Stockmen involved in the delivery thought of the fact that the cell used came from a mammary gland and arrived at Dolly Parton, the country and western singer.

These cells form many of the organs in the body, and arrange themselves into either sheets (such as the skin) or branching ducts (such as kidney, or mammary glands).

However, when challenged by an oncogene, the normal mammary epithelial cells in these involuted glands did not aberrantly activate STAT5 (Figure 8A) when compared to mammary cells that gained caErbB2 first and were later exposed to pregnancy hormones (Figure 3A).

6) More importantly, the Figure 6 shows that when mammary epithelial cells are transfected with miR - 150 and grafted in empty mammary fat pads, they recapitulate the phenotype of activated Wnt signaling (largely hyperplastic mammary gland).

Malignant lymphomas (lymph node tumours), skin cancer (mast cell tumours), bone cancer, and breast cancer (mammary gland tumours) are very common in elderly furkids.

An adenocarcinoma is a malignant growth of these cells most often originating (primary site) from the intestines, uterus and mammary glands.

This is a tumor originating from cells of the mammary glands.

Some of the most common are lymphoma, osteosarcoma, transitional cell carcinoma, mammary gland carcinoma, mast cell tumor, melanoma, fibrosarcoma and leukemia, among others.

These cancerous growths include but are not limited to mast cell tumors, melanomas, lymphoma, mammary gland tumors, and soft tissue sarcomas.

Expression of VEGF has been reported in a wide range of different tumor types in the dog including hemangiosarcoma, malignant melanoma, soft tissue sarcomas, mast cell tumors, nasal carcinomas, intracranial neoplasias, and simple mammary gland adenocarcinomas and inflammatory mammary carcinoma.

Breast Cancer occurs due to abnormal cell reproduction or growth in the mammary glands of female dogs.

In dogs, they often develop from carcinomas of the mammary glands, thyroid, bronchopulmonary epithelium, kidneys, chemoreceptor cells, nasal mucosa, squamous epithelium of the skin, prostate, pancreas, adrenal cortex, and salivary glands.