Sentences with phrase «manipulating genes in mice»

To study these pathways, we use a range of in vitro and in vivo approaches, including manipulating genes in mice and leveraging genome - wide analyses and chemical biology.

Not exact matches

By directly manipulating a portion of the prion protein - coding gene, Whitehead Institute researchers have created mouse models of two neurodegenerative diseases that are fatal in humans.

The team manipulated the genome of mice such that they could initiate neuron death in the hippocampus by turning on specific genes.

Many universities and pharmaceutical companies are engaged in research and development using genetically modified mice that have certain genes manipulated to reproduce human diseases.

There is also the fact that Kono and Kawahara had to manipulate two genes to create their bi-maternal mice — so the differences in lifespan might be due to this genetic manipulation, rather than the absence of paternally imprinted genes.

For example, they succeeded in inserting a gene into a predefined position in the genome (knock - in) in more than 60 per cent of all manipulated mouse cells.

Studies in typical model animals — mice — are rarely illuminating, because the rodents often still behave normally when researchers manipulate genes that should cause these disorders.

By manipulating the same genes, Zuo and his colleagues induced supporting cells located in the inner ear of adult mice to take on the appearance of immature hair cells and to begin producing some of the signature proteins of hair cells.

It would be great if we could just go in and quickly manipulate individual mouse genes and study their function in health and disease, but, until recently, it just wasn't that easy.

Greenberg, an investigator in the Clinical Research Division, and colleagues conducted a pair of experiments by manipulating gene expression directly in the epithelial compartment of the mouse prostate gland to better understand the role of IGF - 1R.

However, researchers at the University of Pennsylvania, led by Dr. George Cotsarelis, have regenerated follicles in mice by manipulating a gene called Wnt.

By manipulating a specific gene in a mouse blastocyst — the structure that develops from a fertilized egg but is not yet an actual embryo — scientists with the University of Florida's McKnight Brain Institute and the Harvard Stem Cell Institute caused cells destined to build an embryo to instead change direction and build the cell mass that leads to the placenta.

has a simple nervous system and can be genetically manipulated quickly, the authors were able to screen dozens of genes — many more than were practical in previous studies using mice.

Because C. elegans has a simple nervous system and can be genetically manipulated quickly, the authors were able to screen dozens of genes — many more than were practical in previous studies using mice.

The reason for this response, Gordon says, was twofold: Firmicutes bacteria transplanted from the fat mice produced more of the enzymes that helped the animals extract more energy from their food, and the bacteria also manipulated the genes of the normal mice in ways that triggered the storage of fat rather than its breakdown for energy.

This gene is also present in mammals and has been artificially manipulated in mice to create extra vertebrae.