Sentences with phrase «many aplastic»

She died in 1934 due to aplastic anemia, which is caused by prolonged exposure to radiation.

These diseases include leukemia or lymphoma, aplastic anemia, severe sickle cell anemia, and severe combined immune deficiency.

Yates didn't think her kids would qualify because her husband had a rare blood disease called aplastic anemia and was not diagnosed with cancer.

Ergotamine (for migraine headaches); Methotrexate (for arthritis); and Cyclosporine (for severe arthritis and psoriasis, aplastic anemia, Crohn's disease, kidney disease, and for after organ transplant surgery).

Dr. Kimball, 93, who had lived for years on Chicago's North Shore before moving to Florida in 1982 after his retirement, died Friday, Dec. 27, of aplastic anemia.

Ernest Robbins Kimball, M.D., 93, a pediatrician and pioneer in the scientific documentation of the medical and psychological benefits of breastfeeding, passed away Dec. 27, 2002 of complications resulting from aplastic anemia.

Rocco Bavuso, left, 22, of Bayside, who was diagnosed with aplastic anemia, meets Christian Verholen, 32, his marrow doner, on May 8, 2018, at the annual Celebration of Life Dinner of North Shore University Hospital's Don Monti Bone Marrow and Stem Cell Transplantation Program at Crest Hollow Country Club in Woodbury.

Aplastic anemia may also be acquired by mechanisms that have still not been clearly established, from exposure to certain toxins to viral infections.

There are types of aplastic anemia that are not associated with short telomeres.

However, the researchers believe that these results are proof of concept that gene therapy is a valid strategy against aplastic anemia; this therapy could also be applied to other genes — besides from telomerase — if a causal role for those other forms of the disease was discovered.

«Researchers fight aplastic anemia using a therapy designed to delay aging.»

It is a completely new strategy against aplastic anemia.

«Indeed, the treatment [with telomerase] significantly prevents mortality from aplastic anemia, and lengthens the telomeres in the blood and in bone marrow,» say the authors.

If so, says Grover Bagby, a hematologist who directs the Oregon Cancer Center at the Oregon Health Sciences University in Portland, further work to decipher the protein's exact function could shed light on how to treat a much larger population of patients with leukemia, certain other forms of cancer, and aplastic anemia.

Other ongoing stem cell trials are targeting blood disorders like aplastic anemia, leukemia, lymphoma, and, of course, sickle - cell disease.

«In the group that was not treated with the gene therapy, the majority of the animals die from aplastic anemia, and they also die much sooner.»

One of them was used to reproduce acquired aplastic anemia: due to various types of damage, some of the stem cells die, and those that remain need to divide more frequently in order to maintain the production of blood cells; as a result of so many divisions, the telomeres shorten and the disease appears.

Many forms of aplastic anemia share an important link with the aging process: the shortening of telomeres, structures that protect the ends of chromosomes.

The second animal model attempts to reproduce hereditary aplastic anemia, which is produced by mutations associated with the telomeres and telomerase.

A common trait in aplastic anemia, regardless of whether it is inherited or acquired, is the presence of short telomeres.

«We provide proof - of - concept that the telomerase based treatment -LRB-...) has a therapeutic effect on the type of aplastic anemia caused by short telomeres,» the authors state in an article in the journal Blood, with Christian Bär among them as the first author, as well as Juan Manuel Povedano.

Human diseases that include dyskeratosis congenita, aplastic anemia, and idiopathic pulmonary fibrosis have been genetically linked to mutations that negatively affect telomerase activity and / or accelerate the loss of telomere length.

In aplastic anemia, the body's immune system appears to destroy these stem cells.

«Study of gene mutations in aplastic anemia may help optimize treament.»

Historically, severe aplastic anemia was almost always fatal due to infections and bleeding.

Doctors generally treat aplastic anemia effectively using immunosuppressives — drugs that prevent the immune system from attacking bone marrow — allowing recovery of the patient's own marrow and long - term survival.

The study, appearing in the New England Journal of Medicine, could lead to tailor - made treatment plans for aplastic anemia patients as part of the emerging precision medicine movement.

Alemtuzumab is in clinical trials for treating aplastic anemia.

In certain types of aplastic anemia, lymphocytes are responsible for attacking the bone marrow stem cells.

It is still an investigational therapy, in combination with other medications, for treating aplastic anemia and other forms of bone marrow failure.

ATG is approved by the U.S. Food and Drug Administration (FDA) for treating moderate and severe aplastic anemia.

Researchers are currently studying MMF in combination with other medicines for treating aplastic anemia.

Cyclosporine is used along with antithymocyte globulin (ATG), another immunosuppressant, for treating aplastic anemia and some other forms of bone marrow failure.

Pluristem Therapeutics Ltd. (Nasdaq: PSTI; DAX: PJT: PLTR) has announced that a seven year - old girl suffering from an aplastic bone marrow whose...

The Aplastic Anemia and MDS International Foundation [phone] [phone] 4330 East West Highway, Suite 230 Bethesda, Maryland 20814 U.S.A.

Old Drug Leads to New Cure Kimmel Cancer Center scientists discover that high dose cyclophosphamide, without bone marrow transplant, cures aplastic anemia and several autoimmune diseases.

Another study is testing whether unrelated donor stem cell transplant can provide better long - term outcomes than traditional immunosuppressive therapy (IST) for children with severe aplastic anemia.

It is a completely new strategy against aplastic anaemia.

The second animal model attempts to reproduce hereditary aplastic anaemia, which is produced by mutations associated with the telomeres and telomerase.

A common trait in aplastic anaemia, regardless of whether it is inherited or acquired, is the presence of short telomeres.

«In the group that was not treated with the gene therapy, the majority of the animals die from aplastic anaemia, and they also die much sooner.»

Kimmel Cancer Center researchers prove that high - dose cyclophosphamide therapy, administered alone (without bone marrow transplantation), is an effective therapy for many aplastic anemia patients.

Aplastic anaemia is a rare, and potentially fatal, disease of the blood, by which the bone marrow is unable to generate blood cells at the appropriate pace.

One of them was used to reproduce acquired aplastic anaemia: due to various types of damage, some of the stem cells die, and those that remain need to divide more frequently in order to maintain the production of blood cells; as a result of so many divisions, the telomeres shorten and the disease appears.

This work, published in «Blood», was carried out by the CNIO Telomeres and Telomerase Group The treatment is based on the transport of the telomerase gene to the bone marrow cells using gene therapy, a completely new strategy in the treatment of aplastic anaemia

Representative bone marrow images of aplastic anaemia (left) and cured anaemia upon the telomerase gene therapy (right).

Now, the same researchers have proven that this therapy may be effective against the types of aplastic anaemia caused by short telomeres.

INHERITED AND ACQUIRED Aplastic anaemia can be caused by inherited mutations in about thirty genes (known to date), several of which are involved in preserving the telomeres.

«Indeed, the treatment [with telomerase] significantly prevents mortality from aplastic anaemia, and lengthens the telomeres in the blood and in bone marrow,» say the authors.

There are types of aplastic anaemia that are not associated with short telomeres.