Sentences with phrase «many biosynthetic»

The fact that we can make biosynthetic insulin (diabetes medication created in engineered bacteria — translated for the rest of us) is amazing and such a jump from using yeast to make bread and beer.

The research, Marker - Aided Transfer of Beta - Carotene Biosynthetic Genes (Golden Rice I) into two Philippine Rice Varieties, was presented by Dr. Antonio Alfonso, project leader and the paper's main author.

ZmPSY1 — phytoene synthase from another food crop, maize, which catalyzes the condensations of two molecules of geranylgeranyl diphosphate to form 11 - cis - phytoene, the first committed step in the carotenoid biosynthetic pathway;

In recent years, scientists have introduced the biosynthetic pathway for provitamin A carotenoids into staple foods, including genetically engineered Golden Rice, which contains 1.6 — 35 μg β - carotene per gram of dry rice.

To produce Golden Rice, 2 enzymes are introduced into the endosperm [phytoene synthase (psy) and phytoene desaturase (crtl)-RSB- via an endosperm - specific glutelin (Gtl) promoter (15), to establish a β - carotene biosynthetic pathway in the rice grains.

The bulk of secondary siRNAs exhibited structure and sequence indicative of a biosynthetic mode whereby each molecule derives from an independent de novo initiation by RdRP.

Analysis of endogenous small RNAs indicated that a fraction derive from a biosynthetic mechanism that is similar to that of secondary siRNAs formed during RNAi, suggesting that small antisense transcripts derived from cellular messenger RNAs by RdRP activity may have key roles in cellular regulation.

Water splitting - biosynthetic system with CO2 reduction efficiencies exceeding photosynthesis.

Biosynthetic studies of the prion protein (PrP) have shown that two forms of different topology can be generated from the same pool of nascent chains in cell - free translation systems supplemented with microsomal membranes.

As more gaps are filled in, he said, a more complete genome will emerge, and that will help researchers dive deeper into the biochemical processes in this alga.That information will then help them understand how and why the organism makes hydrocarbons in very high quantities, how that process is regulated and what the particular biosynthetic pathways are used to make the hydrocarbons.

«Biosynthetic QDs will enable the development of an environmentally - friendly, bio-inspired process unlike current approaches that rely on high temperatures, pressures, toxic solvents and expensive precursors,» Berger says.

This biosynthetic approach provides a viable pathway to realize the promise of green biomanufacturing of these materials.

In the study, the team demonstrated that a biosynthetic gene cluster is capable of producing a whole range of substances, rather than just a single product.

To make this discovery, Serhan and colleagues deconstructed the biosynthetic pathway for maresin biosynthesis and found that human macrophages are responsible for converting DHA to the novel epoxide intermediate «13S, 14S - epoxy - maresin.»

Keasling thinks it is only a matter of time before manufacturers phase out petroleum products in favor of more profitable and sustainable biosynthetic versions.

Syntheses of two natural products reveal a surprising divergence in the plausible biosynthetic precursors of their class.

This biosynthetic hybrid stimulates the development of weak T regs into killer T cells that destroy the immune cells directing the autoimmune attack.

Given the potential for living systems to produce highly complex chemical compounds, researchers working with Michelle C.Y. Chang at the University of California, Berkeley (USA), aimed to manipulate the biosynthetic machinery in cells to use simple fluorinated building blocks to make new organofluorine target molecules.

Her work described the regulatory link between the metabolic enzyme ATP - citrate lyase and histone acetylation levels in mammalian cells, and established that glucose utilization in the hexosamine biosynthetic pathway regulates growth factor receptor signaling.

Both outcomes, the elucidation of the biosynthetic pathway and the discovery of tilimycin as a stable intermediate metabolite, which is even more toxic to human cells, have important physiological and pharmacological implications.

Dr. Kain notes that the L - arginine -(NO) biosynthetic pathway identified in this research may be a common pathway underlying other conditions linked to poor birth outcomes, be they in low or high - income countries such as Canada.

However, Zechner and colleagues found that the source of the blocking, an indole, only enters the biosynthetic pathway at its end.

Until now, most studies of rose fragrance have focused on a biosynthetic pathway that generates pleasant - smelling alcohols, known as monoterpenes, using specific enzymes called terpene synthases.

Taylor believes that an artificial pacemaker coupled with a biosynthetic heart could allow doctors to create made - to - order, rejection - free human heart implants — a salvation for the thousands of people in the United States who die each year while awaiting traditional heart transplants.

After having identified the gene cluster for tilivalline synthesis, the scientists performed comprehensive biomolecular and molecular genetic experiments to track down the complete biosynthetic pathway of tilivalline.

«New biosynthetic pathway unique to pathogenic microorganisms.»

Of the three pathways activated within the UPR, the new work implicates IRE1, which produces a molecule called spliced X-box binding protein 1 (Xbp1s), as a direct activator of the hexosamine biosynthetic pathway (HBP).

The natural product might be made using the snow flea's biosynthetic machinery.

This caused the host bacteria to «spit» out the replicon from the genome, causing a rearrangement of the rapamycin biosynthetic genes.

By manipulating the genetic sequences, characterizing the resulting metabolites and using radioactive labeling experiments it was possible to elucidate the structure of the novel molecules and to unravel the detailed biosynthetic pathways.

Certainly, the biosynthetic pathways of the plant, animal and bacterial pigments soon parted company with their older bacterial and pre-bacterial forbears.

This in turn has enabled chemists to detect the new biosynthetic intermediates, such as precorrin - 6x.»

They managed this trick by stopping the organism partway through the biosynthetic process.

The key to controlling which route isocitrate will take seems to lie in the enzymes surrounding all these reactions: the enzyme isocitrate dehydrogenase keeps it for the fat - metabolism and energy production cycle; the enzymes isocitrate lyase and malate synthase divert it away into biosynthetic processes in the bacterium.

Two of Macchiarini's patients given a biosynthetic windpipe have died, and a third is in intensive care.

The findings also lay the scientific groundwork for the next generation of aroma products, which use the potential of optimized biosynthetic pathways in plants for industrial - scale production of high - quality food odorants.

They identified several key biosynthetic steps and discovered that the enzymes of the symbiotic Streptomyces worked less selectively than those of free - living bacteria.

They previously reported partial success by tweaking natural biosynthetic processes and inserting a gene from A. annua into Escherichia coli, which is commonly used in industrial processes.

An overlooked loop structure of the folate biosynthetic pathway is crucial to produce synergistic activity of these two antibiotics,» said Minato.

These drugs are known to act by targeting specific steps in the folate biosynthetic pathway, and their combined activity is far greater than the sum of their individual activities.

Together, these molecules confer the normal brown body color, possibly as a result of a physical interaction or joint use as precursors in a downstream biosynthetic step.

Through the systematic analysis of ommochrome and porphyrin biosynthetic pathways, the authors identified several genes required for producing planarian pigment.

«An engineered biosynthetic pathway of this complexity had not been demonstrated before.»

They also used plants that were inhibited in their ability to produce floral volatiles after the biosynthetic gene NaChal1 (CHAL) had been silenced.

He has developed an algorithm that identifies the biosynthetic genes in bacterial genomes and has applied this algorithm to the human microbiome.

Macrophage - activating factor produced by a T cell hybridoma: physiochemical and biosynthetic resemblance to gamma - interferon.

Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity.

We did not observe downregulation of BR biosynthetic genes that might account for the loss of BR upstream intermediates.

BR homeostasis is controlled through transcriptional feedback regulation of these biosynthetic genes by known BR signaling TFs, BRASSINAZOLE RESISTANT1 (BZR1) and BRI1 - EMS - SUPPRESSOR1 (BES1) / BZR2.

He is currently developing design principles, tools, and methodologies to mine and characterize novel secondary metabolite biosynthetic pathways and component enzymes by leveraging the DOE JGI's unique resources and capabilities.