Sentences with phrase «many cellular contexts»

Every cell type has the same genes, but each gets different instructions to turn on only those needed in a given cellular context.

The pilot project tested a dozen or so of the most commonly used gene promoters (regions of DNA that facilitate gene transcription) and segments of DNA that encode ribosome - binding sites (sequences of messenger RNA that control protein translation) to determine whether they behave consistently in different cellular contexts.

The main experimental technologies that Instruct offers are complementary, and increasingly link detailed atomic structure of single molecules or macromolecular complexes with their cellular context.

The advent of high - throughput technologies to systematically evaluate drug effects across different cellular contexts enables such discoveries.

Program investigates strategies to understand disrupted genes and cellular contexts, approaching discovery of drugs with

The research of the department focuses on the development of cryo - electron tomography which is widely seen now as a method of unique potential for visualizing macromolecular complexes in their functional cellular context.

The timing of the reprogramming and the factors required seem to vary depending on cellular context [12]--[17].

The main experimental technologies that Instruct - ERIC offers are complementary, and increasingly link detailed atomic structure of single molecules or macromolecular complexes with their cellular context.

Oct4 is a transcriptional regulator that can either activate or repress target gene expression, depending on the cellular context [9], [10].

Not exact matches

Although the work is done in the context of a more general problem — the effect of environmental electromagnetic fields upon cellular functions — Adey is also concerned with the question of how brain waves might play a role in normal brain function.

A comparative analysis of the genomes ofDrosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae — and the proteins they are predicted to encode — was undertaken in the context of cellular, developmental, and evolutionary processes.

It's a first step in mechanistically understanding how cellular stress responses are wired in specific contexts.»

Using this approach, researchers can easily generate diseaserelevant isogenic models to determine the impact of correcting or introducing disease - relevant mutations on cellular phenotypes in a tissue - appropriate context.

Nailing down the precise details and context of developmental molecular - cellular crosstalk in the endoderm of an embryo — where livers form — is critical to this technology's therapeutic potential.

Direct measurement of such compound target engagement in a cellular or tissue context has traditionally been difficult to establish without the development of specific tool compounds and / or protein modifications with reporter functionalities.

Dr. Subramaniam is head of database developments under The Alliance for Cellular Signaling, a multi-institution, multidisciplinary project, utilizing a multitude of high throughput approaches to obtain context - specific knowledge of cellular response to input.

Further research topics are statistical / computational methods to study complex experimental data (e.g. cellular genealogies) and image analysis procedures (e.g. model - based segmentation algorithms in the context of automatic single cell tracking).

For setting cancer in the context of ageing tissue, study of normal adult homeostasis is important — we are studying mutational processes, clonal dynamics and cellular competition in thousands of non-cancerous cells and samples from a range of tissue types, in health and disease.

Melt electrospun calcium phosphate coated scaffolds accelerate ectopic bone formation in the context of a long term cultured cellular construct.

Our goal is to identify signaling pathways which control or coordinate these different phenotypic transitions and to evaluate how these pathways can be influenced by the cellular environment, altered in pathological contexts or serve as therapeutic targets.

This finding suggests that high cellular cholesterol content could push immune cells like macrophages into tumor - fighting mode and presents a very intriguing paradox: namely that inflammation that is deadly in the context of atherosclerosis may be beneficial when it comes to cancer.

In that context, our carbohydrate intake should be low to moderate (only from cellular sources, not as flour), rich in leafy, sulphur - rich and colourful vegetables, moderate in fruit and with a high content of natural fats such as butter, extra virgin olive oil, coconut oil and animal fats.

Both of these molecules sense cellular energy homeostasis and nutrient balance, most notably in the context of calorie restriction and exercise.

The work of Liz Parish, CEO of BioViva, and Dr. Rhonda Patrick of FoundMyFitness, focuses on cellular aging, which in this context is applicable to all humankind.

Continuing with her interest in macro-versus-mirco structures, Smith pushes the boundaries of perception and context as her compositions toe the line between architectural and cellular forms.

Molecular medicine and molecular biochemistry provide the what and how these changes, especially deleterious ones may be treated, cured, suppressed, or understood in context with other gene regulatory mechanisms and transcription and translation coupled systems within the actual cellular environment.

[63] It is not my intention to create a regime that applies to all computers or cellular telephones that police come across in their investigations, regardless of context.