Sentences with phrase «many cellular pathways»

Clinically important findings suggest that targeting the epidermal growth factor receptor (EGFR) and the fibroblast growth factor receptor (FGFR) cellular pathways may benefit thousands of patients with this disease, according to the study published today in the journal PLOS Genetics.

«With this study, we have validated both NOX1 and NOX4 as core mediators of liver fibrosis and laid out the step - by - step cellular pathways that lead to this disease.»

Cell lines are the workhorses of biology, routinely stocked and studied in every laboratory to understand cellular pathways, receptors, targets, hormones, and all aspects of normal and malignant physiology.

Not much is known about the genes and cellular pathways that trigger GNRH release.

«And early developmental brain enlargement can be explained by underlying molecular and cellular pathway dysregulation, leading to altered neuronal cortical networks.»

«Newly discovered cellular pathway may lead to cancer therapies.»

Researchers have pinpointed the cellular pathway that allows the herbicide atrazine to mimic estrogen and fire up cancer cells, according to a study published January 16 in Environmental Health Perspectives.

Scientists have discovered a new cellular pathway that can promote and support the growth of cancer cells.

The other study showed how using a combination of drugs at increased potency could prove an effective therapy against glioblastoma by inhibiting the PI3K and MAPK cellular pathways.

The results suggest the simultaneous activation of certain molecular pathways — actions among molecules in a cell that can lead to change — in particular the MAPK and PI3K cellular pathways, triggered tumor initiation and produced increasingly dense low - grade gliomas that quickly progressed to glioblastoma multiforme (GBM).

Small molecule drugs were used to inhibit the function of a cellular pathway associated with protein synthesis.

But the finding that all these genetic differences trigger the same cellular pathway provides hope for others.

However, more information is needed on cellular pathways and targets affected by these inhibitors before pharmacological optimizations can be pursued.

«The mineral zinc acts as a catalytic, structural and signaling factor in the regulation of a diverse array of cellular pathways involving hundreds of enzymes and proteins,» he said.

«I wonder how many organisms and cellular pathways may utilize prion propagation.»

The growth of pNET malignant cells is closely tied to a cellular pathway known as mTOR (mammalian target of rapamycin).

«We found that a specific cellular pathway, AMPK - PGC1a, likely plays a key role to reduce mitochondrial function and content, which means that new therapeutic approaches that restore and increase mitochondrial function and content could ameliorate or perhaps even arrest chronic kidney disease.»

Researchers also know that a cellular pathway called the Wnt signaling pathway induces hair growth.

When the scientists tried to trigger LTP in these brain slices with electrical stimulation or chemicals, they found that methods that fired up cellular pathways involving the molecule cyclic adenosine monophosphate (cAMP) didn't work.

EDMONTON, ALBERTA — Researchers have identified a key cellular pathway by which the herbal medicine ginkgo biloba may protect brain cells.

«The parasite achieves this by sending proteins into the host cell that manipulate the host's own cellular pathways, enabling it to grow and reproduce.»

In particular, he is interested in explaining how inflammation in the body alters cellular pathways, resulting in cancers and other diseases.

Genome editing is used in many different cell types and organisms to specifically modify genes for the interrogation of fundamental cellular pathways.

These studies will provide new leads to understand the cellular pathways that control K2P function in other organisms.

The multitude of cellular pathways targeted by anthelminthics is difficult to explain.

The Cosford lab employs medicinal chemistry and chemical biology approaches to probe cellular pathways that regulate cell survival pathways in deadly tumors.

In adrenocortical carcinoma, niclosamide has anticancer activity through its inhibition of multiple cellular pathways and impairment of the cellular metabolism [43].

The primary defects that cause muscle degenerative diseases are affecting distinct cellular pathways; accordingly, there is a large variability in clinical pathology and onset.

We want to understand how cellular physiology is controled by basic molecular and cellular pathways regulating the biology of potassium - selective ion channels.

Whitehead Institute scientists report that the gene mutated in the rare hereditary disorder known as Birt - Hogg - Dubé cancer syndrome prevents activation of mTORC1, a critical nutrient - sensing and growth - regulating cellular pathway.

This is why recent work in the field of cancer research has focused on picking apart the complex cellular pathways involved in the development of different cancers and identifying the roles of key proteins involved, with the goal of being able to discriminately and effectively eliminate cancerous cells from the body.

Using DOS and small - molecule screening, Schreiber helped illuminate many cellular pathways, including the nutrient - response signaling network involving TOR proteins in yeast and mTOR in mammalian cells.

We are also interested in the evaluation of novel agents which inhibit cellular pathways known to be important in myeloma pathogenesis.

Kontoyiannis D., Boulougouris G., Manoloukos M., Armaka M., Apostolaki M., Pizarro T., Kotlyarov A., Forster I., Flavell R., Gaestel M., Tsichlis P., Cominelli F., Kollias G., 2002, «Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor - induced Crohn's - like inflammatory bowel disease», JEM, 196, 1563 - 74.

Padmanee Sharma, M.D., Ph.D., and colleagues discovered a cellular pathway whose activation seems be important for having a good response to ipilimumab.

Another innovative method used to track cellular pathways involves the rabies virus.

Though this exploitation of biochemical and cellular pathways, the Gelipo - TRAIL - Dox combo accumulated more than the controls in the affected tumor tissue and had a greater cytotoxicity.

A nanoparticle delivery system exploits biochemical and cellular pathways in tumor cells to deliver two different drugs to different locations in the cell.

Distinct cellular pathways select germline - encoded and somatically mutated antibodies into immunological memory.

This in turn can provide insight into the key cellular pathways that are potentially amenable for therapeutic intervention.

The model will describe cellular pathways that contribute to tumor formation and explain in detail how the genetic disposition of an individual can activate expression of genes that drive uncontrolled cell growth and lead to cancer.

Revelations about a key cellular pathway have important implications for neurodegenerative diseases like ALS and frontotemporal dementia.

Using these orthogonal measures of cellular pathway analysis, we confirmed that HPP - 4382, in contrast to bardoxolone, did not induce significant cellular stress at high doses as measured by HSPA6 expression and that the mechanism of HPP - 4382 activity does not appear dependent on NF - B as ICAM1 expression is not induced by HPP - 4382 (data not shown).

Novel treatments for cancer depend on the ability to modulate aberrant cellular pathways and effectively deliver therapeutics to the tumor.

Howard Hughes Medical Institute researchers have pinpointed defects in a critical cellular pathway that can lead to the death of dopamine - producing nerve cells and ultimately symptoms of Parkinson's...

First, Nanog opened two key cellular pathways, known as Rho - associated protein kinase (ROCK) and Transforming growth factor beta (TGF - β).

Now researchers at the Salk Institute for Biological Studies have identified an essential cellular pathway in zebrafish that paves the way for limb regeneration by unlocking gene expression patterns last seen during embryonic development.

March 13, 2017 Parallel cellular pathways activate the process that controls organ growth A new study from the University of Chicago suggests that while proteins that control organ growth accumulate around the edges of cells, they actually function at a different cellular site.

It is likely that these genes are components of related molecular or cellular pathways, or they might be targets of common regulatory mechanisms, or both [52]--[54].

In order to confirm that the cytotoxic effect seen in the amiodarone HCL - treated NSCs was specific to the activity of the drug, we first sought to determine which cellular pathways were affected in the amiodarone HCL susceptible NSC population relative to unaffected dopaminergic neurons receiving the same treatment (Fig.