Sentences with phrase «many complex diseases»
``... to fund and initiate collaborative and groundbreaking research into chronic complex diseases so that patients will be able to live life more fully.
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The naïve moralism in this area can be maintained only by ignoring the facts that inebriety is as much a symptom as a cause of the disturbed interpersonal life of the alcoholic, that alcoholism is a complex disease involving physical, cultural, and socio - psychological as well as moral factors, and that homelessness is in itself a complex phenomenon, not the simple product of excessive drinking.
On the contrary, the research findings indicate forcefully that alcoholism is a complex disease in which a variety of factors play a role.
Cancer is a complex disease and there are many factors that can contribute to its development, however there is broad consensus within the scientific community that no single food causes cancer.
Our pediatric nephrologists specialize in the treatment of this complex disease and do our best to provide care for children with nephrotic syndrome in the outpatient clinic.
At Floating Hospital for Children at Tufts Medical Center in Boston, you'll know the peace of mind that comes as a result of an exceptional team of pediatric oncologists and hematologists who treat these complex diseases.
Tufts Medical Center is a 415 - bed robust organization, providing everything from routine medical care to treating the most complex diseases affecting adults and children.
«Addiction is a complex disease,» he said.
The first environment - wide association study borrows from genomics to reveal new leads in major complex diseases
It also sought to match epigenetic changes and genetic differences to the physical characteristics of each cell type and use this knowledge to understand how these can lead to blood disorders, cancer and other complex diseases.
The machine could help unravel the genetic basis of many complex diseases, including diabetes, Alzheimer's disease, and some cancers.
Despite the proliferation of GWAS, the associations found so far have largely failed to account for the known effects of genes on complex disease — the problem of «missing heritability.»
Complex diseases, on the other hand, do not have a clear mutational footprint.
The advantages of MFCs may allow widespread use of diagnostic procedures that are currently too expensive to implement (e.g., prescreening for cancer) while the new capabilities may dramatically improve our ability to understand complex diseases such as cancer (e.g., through single - cell analysis).
«Many diseases, especially complex diseases, involve multiple genes, and this system could be used therapeutically to target and activate multiple genes together and rescue these disease phenotypes,» says Albert Cheng, a graduate student in the Jaenisch lab and co-author of the Cell Research paper.
Unlike monogenic diseases, which are caused by a single mutation in the genome, cardiovascular diseases belong to the group of complex diseases.
They are of high interest for the study of complex diseases that have no clear mutational cause,» said Yamashita, who added the alanine threonine substitution was a rare variant.
Extracting clinically relevant information pertinent to a complex disease process, drawing from a data set of 19,000 genes, required a creative rather than systematic research approach.
Today in Cell and associated journals, 24 research studies from the landmark BLUEPRINT project and IHEC consortia reveal how variation in blood cells» characteristics and numbers can affect a person's risk of developing complex diseases such as heart disease, and autoimmune diseases including rheumatoid arthritis, asthma, celiac disease and type 1 diabetes.
In conclusion, these results highlight the importance of large - scale genetic studies to better characterize complex diseases.
Highlighting the collaboration, Hughes said, «This study demonstrates how the synergy between experimental and computational approaches can help unravel the nature of a complex disease such as HD.»
However, it was not clear whether changes in lncRNA genes could put people at risk of developing complex diseases in the same way that changes in protein - coding genes do.
These findings also will help investigators to understand the etiology of common complex diseases because we can anticipate more functionally significant variants to influence diseases with a stronger environmental component, while uncommon variants may be more important for diseases with a weak environmental contribution.
So, like, complex diseases like diabetes or cancer or schizophrenia, the keep coming up with these same results.
DNA testing companies use the SNPs to calculate people's genetic risk of developing complex diseases.
When it comes to pinning down your risk of more complex diseases, it's a bit challenging for someone of mixed ethnicity.
«Multiple sclerosis is arguably the most complex disease ever described,» says Sergio Baranzini, a geneticist at the University of California, San Francisco.
«Ten years ago, geneticists worked in isolation, but now there is a premium on leadership — individuals able to pull together consortiums of geneticists to amass the cohorts of thousands of subjects required to address problems of complex disease genetics,» he says.
Scientists generally cringe at setting firm timelines for research goals and for cancer in particular, which is a complex disease that experts consider a set of more than 200 diseases.
«Dogs naturally suffer complex diseases, including mental disorders that are similar to those in humans.
«TB is a complex disease and modelling it is difficult but we've successfully used our model to replicate real world situations and are confident that it can be used to predict the effects of various changes in the way we tackle the disease.»
As efforts continue to characterise the genetic underpinnings of complex diseases, the data and results of this study are expected to enable the next wave of discoveries.
«We are excited about these findings — they solve a mystery and show how fat synthesis protects cells from dysfunction and disease,» said Robert Farese, Jr., professor of genetics and complex diseases at Harvard Chan School.
«To better understand what happens when cells are overwhelmed with fat during obesity, we first have to understand how the system normally deals with fluctuations in lipids,» said Tobias Walther, professor of genetics and complex diseases at Harvard Chan and co-senior author of the study.
His research interests include the molecular underpinnings of cervical cancer (including developing genetic screens), the identification of the genetic determinants of quantitative traits in humans, and the application of massively parallel sequencing technology for understanding the genetics of complex disease.
But it also gives scientists a wealth of new data and a unique approach by which to better understand and develop therapeutics against complex diseases.
Some Mendelian disorders are known to predispose patients to certain complex diseases, but these co-occurrences have thus far only been studied on a small - scale basis.
«For the first time we've found that almost every complex disease has a unique set of associations with single - gene diseases.
In 2007, researchers came to appreciate the extent to which our genomes differ from person to person and the implications of this variation for deciphering the genetics of complex diseases and personal traits.
This images gives a look at how closely related complex diseases are with each other, based on co-morbidity data.
This essentially gives us «barcodes» of specific gene loci, which we can use to help untangle the complex genetics of complex diseases,» said Andrey Rzhetsky, PhD, professor of genetic medicine and human genetics at the University of Chicago, who led the study.
«These loci represent great candidates for uncovering subtle genetic variations, some which might not directly cause Mendelian disease but still impact the risk for developing complex diseases.»
The team also discovered that genetic insults underlying Mendelian diseases do not appear to independently contribute to complex diseases but likely interact in a combinatorial way to ultimately cause the disorders.
Analyzing more than 120 million patient records and identifying trends of co-occurrence among hundreds of diseases, they created a unique genetic map that has the potential to guide researchers and clinicians in diagnosing, identifying risk factors for and someday developing therapies against complex diseases.
They studied these correlations in 65 complex diseases affecting almost every system in the body, including arthritis, depression and lung cancer, and in 95 Mendelian disease groups (representing 213 disorders).
Called the HapMap, this catalog has made the use of SNPs to track down genes involved in complex diseases — so - called genome - wide association studies — a reality.
This genetic map is immediately useful for geneticists and clinicians as a gauge to the level of risk of developing complex disease among their patients with Mendelian diseases.
«Genetic map developed linking complex diseases.»
After finishing my work here and going back to China, I would like to continue working in complex disease genetic research, because China offers a good population basis, and there are so many devoted scientists.
His overarching aim is to advance network medicine by identifying and targeting signaling networks associated with complex diseases.