Sentences with phrase «many failed clinical trials»

The value of Innate's shares tanked in late - June following a failed clinical trial for its multiple sclerosis treatment.

After a failed clinical trial earlier this summer, the company's stock plummeted.

Shares plummeted Tuesday by more than 90 percent on a failed clinical trial for its multiple sclerosis treatment.

Currently, 92 per cent of new drugs fail clinical trials, even though they have successfully passed animal tests.

During a conversation this month in his office at Weill Cornell Medicine in New York City, Fine rattled off more dismal stats, like the many failed clinical trials of experimental drugs for glioblastoma; like the paltry increase in life expectancy for people with glioblastoma from 12 months in 1990 to 15 today; like the stupid (in hindsight) assumptions about how glioblastomas grow and how to study them in mice.

In an early Phase I study, an Alzheimer's drug candidate showed reduced side effects compared with similar drugs that have failed clinical trials.

Not exact matches

In particular, the complaint alleges that throughout the Class Period, defendants made materially false and / or misleading statements and / or failed to disclose that (1) the trials for GED - 0301 suffered from fatal design defects, such that GED - 0301 had failed to demonstrate meaningful clinical efficacy; (2) the growth of Otezla sales had dramatically slowed during Celgene's third fiscal quarter of 2017; and (3) the clinical and nonclinical pharmacology data in Celgene's new drug application («NDA») for Ozanimod were insufficient to permit a complete review by the FDA, which resulted in the FDA issuing a refusal to file letter to Celgene regarding the NDA.

But while thousands of clinical trials on immunotherapy drugs, of which many are predicted to fail, are springing up, the depth of information on neoantigen vaccines is much shallower: Just two studies on neoantigen vaccines for melanoma, recently profiled in Nature, were completed last year in Boston and Germany.

But a late - stage clinical trial called CheckMate - 026 for the drug failed to meet its primary goal of halting cancer progression in advanced, untreated patients whose tumors consisted of at least 5 % PD - L1.

That also could bring new life to pancreatic cancer drugs that have failed in clinical trials because they were unacceptably toxic to the rest of the body, she says.

On average about 99 % of all drugs in clinical trials never actually make it to approval, and drugs are still failing late - stage trials in 2017.

Solanezumab, a drug developed by Eli Lilly that also acts on the amyloid hypothesis, failed some key clinical trials, though the company is still testing it in the pre-clinical stages of the disease.

Shares of biotech Sage Therapeutics slumped 15 % in Tuesday afternoon trading after the company's experimental seizure disorder treatment, brexanolone, failed to meet the key goal in a clinical trial.

The flagship drug of San Diego's MediciNova failed a midstage clinical trial for methamphetamine dependency, casting doubt on prospects for a product it has placed great hopes in.

Cases brought against producers of legal highs could fail due to the absence of any clinical trials on humans, MPs heard.

A day after Collins was heard off the House floor discussing the possible sale of an Australian biotech stock, the company issued a news release further confirming its experimental treatment for multiple sclerosis had failed in clinical trials.

WASHINGTON — A day after Rep. Chris Collins was heard off the House floor discussing the possible sale of an Australian biotech stock, the company issued a news released further confirming its experimental treatment for multiple sclerosis had failed in clinical trials.

The value of stock in a multiple sclerosis drug company - which includes large holdings by members of Congress - collapsed Tuesday when company officials announced the drug failed during recent clinical trials.

One potential drug, Tariquidar, is currently in clinical trials, but in the past, other potential drugs have failed at that stage.

If the prevention trials fail, it will be up to academics to persuade companies back to the table with solid preclinical and early clinical data, says Mucke.

For the most part, clinical trials in Alzheimer's disease have been woefully disappointing — failed drug after failed drug.

But billions of dollars have poured into large - scale clinical trials of amyloid - lowering therapies that so far have failed.

Until now sepsis has been treated as an inflammatory disease but more than 30 clinical trials of anti-inflammatory drugs for sepsis have failed.

The lab tested more common hydrogels but found that they were unable to provide the same controlled release and also failed to provide an additional benefit over CDN treatment seen in clinical trials.

Clinical trials testing various cancer vaccines have failed miserably; in one, a melanoma vaccine called Canvaxin did not improve the survival of patients, an outcome that ultimately forced the drugmaker to sell itself to another firm.

So, although the drugs looked like they worked in the lab, when they moved to clinical trials, they failed.»

Northfield Laboratories, Inc., in Evanston, Ill., has been conducting clinical trials for its oxygen - carrying red blood cell substitute, PolyHeme, but in May said the product failed to meet the primary goals of mortality and safety in an important phase III study.

Furthermore, dietary antioxidants have failed as anticancer agents in clinical trials (4).

Several vaccines against HSV - 1 tested in clinical trials for the prevention of adult - to - adult transmission have failed, Leib noted, but none have been tested for prevention of adult - to - baby so - called «vertical transmission» of the virus.

Many of the clinical trials carried out to date with with synthetic cannabis have failed, with no measurable effect being recorded in patients.

Even when an experimental drug fails in clinical trials, there is often a patient or two — maybe 1 in 50, he said — whose cancer stops growing or even vanishes, at least temporarily.

However, a clinical trial that began almost 10 years ago was terminated early because not only was semagacestat found to fail, patient groups that received the drug showed exasperated symptoms compared to the placebo group.

The study can be seen in Cell Reports and provides an explanation for why the clinical trials for Alzheimer's disease drugs have failed and gives new light on the discord between preclinical and clinical findings.

This finding helps explain why two large clinical trials testing HIV pre-exposure prophylaxis, or PrEP, in women failed to show efficacy.

Michos notes that a recent randomized clinical trial published in JAMA Cardiology failed to show any cardiovascular benefit with high - doses of monthly vitamin D supplements among participants living in New Zealand.

But then, in 2014, two large - scale, multinational clinical trials aimed at treating fragile X by inhibiting that pathway failed.

And up to half of participants enrolled in clinical trials to treat PTSD fail to respond to therapies including serotonin - reuptake inhibitors — a class of drugs often used as antidepressants — and cognitive behavioural therapy.

Worse, many promising drug candidates fail in phase II clinical trials when their efficacy is put to the test.

«Every clinical trial for TBI treatment to date has failed to demonstrate reliable and safe improvement in outcomes,» she said.

But the most promising candidates — compounds called vaginal microbicides that thwart the virus at the site of infection — have failed repeatedly in clinical trials.

But the results of the clinical trial, first presented at a meeting a year ago, showed that the vaccine failed to raise an adequate CD8 + response, and it protected only two people.

A new type of pump to help failing hearts will undergo clinical trials in autumn 2004 in the UK.

Two new phase III clinical trials investigating the efficacy and safety of bitopertin, a glycine uptake inhibitor considered to be a promising new add - on therapy for treating negative symptoms in schizophrenia, failed to show a benefit of the drug over placebo.

Despite the urgent need, almost all clinical trials of neuroprotective therapies to date have failed to translate from the laboratory to the clinic, according to the RBC research team.

«We can reduce the toxicity of approved protein drugs, and may also be able to rehabilitate protein fusion drugs that have so far failed in clinical trials due to unacceptable side effects.»

Large clinical trials testing therapies in patients who test positive for the standard biomarkers have generally «all failed to improve outcomes.»

«The clinical trials for treatments have all failed because by the time of diagnosis the brain is so far gone that it's like pouring gas into a car that has no engine.»

While the use of antiangiogenesis drugs that block the growth of new blood vessels can improve the treatment of some cancers, clinical trials of their ability to prevent the development of new metastases have failed.

But while many appear to be effective in animal models, most fail when tested in late - stage human clinical trials.

While the last decade has seen many potential new agents for hepatocellular carcinoma fail in clinical trials, phase I and II data from early regorafenib trials were promising, and led to the initiation of this international, multi-center phase III trial.