Sentences with phrase «many human genetic studies»

The discovery could shed light on why many human genetic studies have previously not been able to fully explain how certain diseases, such as type 2 diabetes and obesity, are inherited.

«The poster child for human genetic studies leading to new therapies is PCSK9,» Stitziel said.

The relevance of these mutations was reinforced by the fact that many also were found in the same chromosomal regions previously shown to be associated with HLHS from human genetic studies.

«This finding demonstrates the power of human genetic study of rare conditions.»

Next, the scientists turned to human genetic studies to see how CYFIP might interact with other factors.

Finally, recent large - scale human genetic studies have implicated mutations in the NMDAR itself and serine racemase, as well as many genes associated with the postsynaptic density, with increased risk for schizophrenia.

Human genetic studies strongly point to apolipoprotein E (APOE) and microglia (the immune cells of the brain) as, respectively, the most important gene and cell type in the chain of events leading to Alzheimer's disease (AD), a common disorder in the elderly in which the brain is damaged and memories falter.

This understanding can be gained from studies of model organisms, in vitro experiments, bioinformatic analyses and human genetic studies.

Importantly, this establishes the true causative lesion, which is often impossible to ascertain from human genetic studies alone.

Human genetic studies have identified novel DNA variations in the genome associated with AMD, but most of them are not located within gene protein - coding regions, making their study a challenge.

Not exact matches

«We suspected that the young are most vulnerable because of their immature immune systems, but we didn't have a lot of hard evidence to show that before,» said study lead author Bo Hang, a Berkeley Lab staff scientist who previously found that thirdhand smoke could lead to genetic mutations in human cells.

A degree of kinship between human beings and the rest of physical creation has always been clear to an extent, but the depth and detail of our interrelationship with the rest of life on the planet is being confirmed over and over again in breathtaking detail by new scientific advances such as genetic studies and molecular biology.

Do a bit of study regarding genetic drift, population bottlenecks and the impossibility of the entire human race having come from 3 breeding pairs of humans, with all the males being 1st order relatives, a mere 4,000 years ago.

Blood pressure responses to high and low salt intakes may share similar genetic control mechanisms, according to a new study published in the Journal of Human Hypertension.

Using studies of twins who had been separated at birth, yet displayed remarkably similar characteristics of personality despite differences in environment, Harris demonstrated the importance of genetic predisposition as a factor in human development.

«Like human societies, whales value culture and family ties: Groundbreaking genetic kinship study of beluga whales.»

Of the thousands of ancestral variants reintroduced into modern humans, only 41 have been linked in genetic studies to diseases, such as skin conditions and neurological and psychiatric disorders, he said.

Molecular biologist Christina Warinner studies calculus, or fossilized dental plaque, which contains a trove of genetic clues to past human diet and disease.

Low levels of physical activity and inefficient sleep patterns intensify the effects of genetic risk factors for obesity, according to results of a large - scale study presented at the American Society of Human Genetics (ASHG) 2017 Annual Meeting in Orlando, Fla..

One wave of ancient human migrants out of Africa gave rise to all non-Africans alive today, three separate genetic studies conclude.

I continued working at the interface of science and epidemiology, first with Genaissance Pharmaceuticals, a New Haven - based pharmacogenomics company, where I was involved in the fascinating study of human genetic variation and population genetics.

In addition to exploring the specific functions of genetic material that the Turkish population inherited from Neanderthals, the study also examined the Neanderthals» influence on human populations in Western Asia more broadly.

But despite artificial influences the study found genetic differences between humans are what continue to fuel evolution.

The study illustrates the versatility of SNAs, which are nontoxic to humans and can be used, in principle, for any known genetic target.

The study results build on genetic and epigenetic basics, including that the blueprint for the human body is encoded in genes that direct the building of one or more proteins.

The study of the new strain's genetic structure might also lead researchers to a better understanding of how the microbe adapts itself to human hosts.

Dr Tomi Pastinen, senior author on the second study, from McGill University said: «We have created an expansive, high - resolution atlas of variations that deepens our understanding of the interplay between the genetic and epigenetic machinery that drives the three primary cells of the human immune system.

This study highlights the shared genetic etiology of many canine and human genetic disorders, and provides new tools to investigate PRA mechanisms while the beloved dogs benefit from genetic testing.

Genetic studies show that mollusk ancestors split from the vertebrates around 1.2 billion years ago, making humans at least as closely related to shrimps, starfish, and earthworms as to octopuses.

The researchers did a small study of existing genetic data from the human skin microbiome and estimate that 20 percent of the human population have S. epidermidis strains that make 6 - HAP on their skin, Gallo says.

Recent genetic studies have confirmed the first humans to arrive in the Americas traveled via Beringia.

In a new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cooking.

They studied genetic data from 1,983 living individuals across Africa, Europe, Asia, Oceania, and the Americas and concluded that Neanderthals or another ancient hominid group must have interbred with our ancestors at least once, in the eastern Mediterranean, soon after humans migrated out of Africa.

The first government - funded human genomics research study performed on African soil — aimed at unlocking the unique genetic character of southern African populations — has revealed a high level of genetic diversity.

«Fascinating genetic studies had been done on SMCHD1 that linked the gene to FSHD2, a rare muscular dystrophy involving the interaction of multiple genetic sites, but it had never been connected to craniofacial abnormalities,» says Michael Talkowski, PhD, of the MGH Center for Human Genetic Research, co-senior author of the Nature Geneticsgenetic studies had been done on SMCHD1 that linked the gene to FSHD2, a rare muscular dystrophy involving the interaction of multiple genetic sites, but it had never been connected to craniofacial abnormalities,» says Michael Talkowski, PhD, of the MGH Center for Human Genetic Research, co-senior author of the Nature Geneticsgenetic sites, but it had never been connected to craniofacial abnormalities,» says Michael Talkowski, PhD, of the MGH Center for Human Genetic Research, co-senior author of the Nature GeneticsGenetic Research, co-senior author of the Nature Genetics paper.

Professor Ali Tavassoli, who led the study with colleague Dr. Ishna Mistry, explains: «In an effort to better understand the role of HIF - 1 in cancer, and to demonstrate the potential for inhibiting this protein in cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environment.

While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.

Currently only a handful of known genetic mutations have been found to account for about 10 percent of glaucoma, says Liu, corresponding author of the study in the journal Human Molecular Genetics.

While a lot of archeological work had been done on these settlements, this is the first study to examine the genetic properties of the human remains.

Dueling genetic studies based on the DNA of modern dogs and wolves suggest the fellowship between humans and dogs could have been forged in the Middle East, Central Asia, East Asia or, as Goyet's archaeological evidence suggests, in Europe.

«Most previous research into ways of delaying the onset of HD symptoms have focused on studying the mutant protein in cells or in animal models, but the relevance of abnormalities in those systems to what actually happens in patients remains a huge assumption,» says James Gusella, PhD, director of the Center for Human Genetic Research (CHGR) at Massachusetts General Hospital (MGH), corresponding author of the Cell paper.

Often, those smaller animals express the genetic abnormality very differently from humans, says clinical scientist and pediatric neurologist James Dowling at the University of Michigan, Ann Arbor, who studies the myopathies and their genetic causes in both children and zebrafish.

Professor Thomas Higham said: «Other recent studies of Neanderthal and modern human genetic make - up suggest that both groups interbred outside Africa, with 1.5 % -2.1 % or more of the DNA of modern non-African human populations originating from Neanderthals.

The investigators plan to further study how these genetic differences may affect the bacterium's ability to evade the human immune system.

Genetic studies released in 2016 put a new molecular spin on humans» long - ago migrations.

The Genographic Project, launched in April 2005, is a five - year genetic anthropology study that aims to map historical human migration patterns by collecting and analyzing DNA samples from over 100,000 people across five continents.

Marathon running might be in some people's genes, according to a new study, which shows that a genetic mutation that boosts muscle endurance has spread widely in some human populations.

After starting with these human observations, Palmer's team is now studying the same delay discounting - related genetic traits in rodent models.

A new study suggests that the debilitating disease schizophrenia may be a byproduct of the genetic changes that fueled the evolution of the expansive human brain.

Or perhaps the answer lies in the interplay between the immune system and human genetic variability: Studies have highlighted genes that strongly influence who is most susceptible — and who is most resistant — to HIV infection and disease.