Sentences with phrase «many human pathologies»

«Lots of ideas and efforts have been made to use NSAIDs to treat human pathologies, including colorectal cancer and other diseases,» Miller said.

«The findings underline the therapeutic potential of this endogenous anti-inflammatory factor, Del - 1, in further human pathologies where the levels of Del - 1 are reduced,» Chavakis said.

Jasper says age - related loss of metabolic balance is a risk factor for many human pathologies.

The authors also found abnormalities in the subthalamic nucleus occur earlier than in other brain regions, and that subthalamic nucleus nerve cells progressively degenerate as the mice age, mirroring the human pathology of Huntington's disease.

iPS cells enable to enlarge applications for modeling numerous human pathologies, reproducing the dysfunction processes of damaged tissue, and developing targeted medicine.

The setting in Honolulu captured my conflicted mood perfectly — human pathology inside the convention center and great natural beauty outside of it.

The unit study macromolecules that are central in basic processes of cellular life, as well as for specific human pathologies.

Recently, loss - and gain - of - function mutations in K2P channels have been directly linked to human pathologies (Birk Barel syndrome, familial migraine with aura, cardiac conduction disorder).

From a public health perspective, aging is also the critical risk factor for a variety of human pathologies, including neurodegenerative diseases, many forms of cancer and metabolic disease.

Biomedcode's unique animal models of human TNF - depended arthritis have offered the first proof of concept for the central role of TNF in the development of human pathology.

There was no difference or age - dependent increase in the level of TBS - soluble or FA - treated Aβ peptides in cerebellum between non-transgenic and transgenic animals (Additional file5: Figure S4); a finding that is in agreement with the human pathology [49].

Zheng is now trying to translate this finding to human pathology, where mutations in human ubiquitin ligases cause low affinity bindings to target proteins.

Human pathology studies suggest that tumor cells invade collectively as strands, cords and clusters of cells into the stroma, which is dramatically reorganized during cancer progression.

The goal of this Unit is based on the simple, but fundamental, concept that an understanding of normal developmental regulation should provide us with a better understanding of the basis of human pathology.

Such a similarity makes TNFΔARE a unique model of a complex human pathology appropriate for the simoultaneous testing of novel therapeutics and small molecule inhibitors on two different pathologies.

We explore the relations existing between cysteamine - driven inflammation versus cytoprotection in vivo and in human pathologies.

Since a drug is assumed to be effective against its target human pathology and since the vast majority of deaths in the developed world are from ageing - related causes, it is inappropriate to describe something as an anti-ageing drug unless one has good reason to believe that it will appreciably extend the life expectancy of those in the developed world who receive it.

Our scientists couple such technological advances with a deep knowledge of biological processes, creating multidisciplinary teams that can decipher the basis for human pathology.

The only animal model that reproduces the human pathology and biochemical mechanisms is the Golden Retriever dog.

chondrodysplasia: any growth plate (cartilage) disturbance resulting in canine dwarfism; in human pathology, it has a different meaning: enchondromatosis, a rare disorder marked by enlarged cartilage and tumors in joints.

Behavior analytic theory came to be regarded as too narrow to account for the complexities involved in human pathology.

Not exact matches

The pathologies of speech, hearing, and sight demonstrate the profound dependence of all of the higher human functions upon bodily structures.

Examines the pathology of normalcy in our society and the creation of a society in which human needs will be fulfilled.

It also follows from Legutko's view that liberal orders like the EU recreate the pathologies of communism, albeit with a human mask.

Assagioli has an appreciation for the way in which the intensive study of pathology by psychoanalysis and depth psychology has enlarged and deepened our understanding of the human psyche.

The growth contributions of the traditional therapies are, for the most part, concentrated in two areas — their illumination of the depths and complexity of human personality, and their insights about the nature and dynamics of deeply blocked growth (pathology).

He saw human personality in biologically reductionistic, pathology - centered ways.

But it does throw some light upon the dark side of the human story if we see human cruelties and destructiveness as corruptions of the power to love, and thus as belonging not to the norm of human nature but to its pathology.

There are great differences among these three spokes - persons for social possibility and pathology, but they all focus on the fact that societies have ways in which to articulate and distort certain kinds of truth that make human life possible Or problematic.

Jung sought an explanation for the human psyche that went beyond what he once called «the curse of pathology.»

First of all, it implies some superficial beliefs about the place of sexuality in human experience (we might regard these as being in the antechamber of the temple of sacred sexuality proper): the belief that sexuality is a key, perhaps even the key, component of the quality of being human (in this, of course, lies the pervasive heritage of Freud); the belief that modern Western culture, and especially American culture, has unduly suppressed sexuality (this is the anti-Puritan aspect of the proposition), and, that, as a result, not only are we sexually frustrated (and that frustration carries all sorts of physical and psychological pathologies in its wake), but our entire relation to our own bodies as well as the bodies of others has become distorted.

Gradually, over the last ten years or so, my counseling and caring ministry has shifted from a diagnostic, treatment approach (a pathology model) to a human development, positive - potentials approach (a growth model).

«Pathologies of power: rethinking health and human rights,» American Journal of Public Health 89 (10): 1486 - 1496.

Evidence from animal and small - scale human studies suggests that pioglitazone may prevent or reverse Alzheimer's - related pathology and symptoms.

«Norovirus is one of the deadliest human pathogens that we know the least about,» said first author Craig B. Wilen, MD, PhD, an instructor in pathology and immunology.

«Most mouse models produce pathology that only distantly resembles human diseases.

If you give a flu virus to ferrets, they develop an analogous pathology to humans.

«We feel it's critical that the scientific community consider the potential hazards of all off - target mutations caused by CRISPR, including single nucleotide mutations and mutations in non-coding regions of the genome,» says co-author Stephen Tsang, MD, PhD, the Laszlo T. Bito Associate Professor of Ophthalmology and associate professor of pathology and cell biology at Columbia University Medical Center, and in Columbia's Institute of Genomic Medicine and the Institute of Human Nutrition.

«Before this study, it was not known if it is possible to produce sufficient numbers of these cells and successfully use them to remuscularize damaged hearts in a large animal whose heart size and physiology is similar to that of the human heart,» said Dr. Charles Murry, UW professor of pathology and bioengineering, who led the research team that conducted the experiment.

We see parasites and pathologies far more severe than in domestic animals or humans.

Although the drug levodopa can relieve some symptoms, there is no cure — intensifying the pressure to find an animal model that can help clarify the pathological processes underlying human PD and find new medications to treat the pathology and / or relieve symptoms.

If the same dynamic plays out in human brains, hyperconnections in the developing cortex could result in the neural pathologies observed in human autism, Kanold said.

«Every human carries trillions of bacteria in their gut (gut microbiome) and recent advances in research indicate that these tiny passengers play an important role in our overall health maintenance,» says Ashutosh Mangalam, PhD, assistant professor of pathology at the University of Iowa Carver College of Medicine.

This evidence indicates that LB1 is not a modern human with an undiagnosed pathology or growth defect; rather, it represents a species descended from a hominin ancestor that branched off before the origin of the clade that includes modern humans, Neandertals, and their last common ancestor.

In contrast, Neandertals and modern humans share derived wrist morphology that forms during embryogenesis, which diminishes the probability that pathology could result in the normal primitive state.

The physician - scientist may study the same properties of the same molecule but for a different reason: because he or she believes that those studies will provide information on the fundamental pathology of a disease or insight into human biology that will provide a better understanding of healthy versus diseased states.

So you can put all this together and say it's reasonable that some of this is really driving pathologies in humans.

So it is reasonable to say that this is driving pathologies in humans.»

New findings published in Biological Psychiatry brings us closer to understanding the pathology of autism, and the point at which it begins to take shape in the human brain.

Knowledge of these mechanisms in songbird species with different social and mating systems may in turn elucidate social and sexual pathologies in humans.