Sentences with phrase «many human patients»

Valeri said drugs that work in mice have only proved effective in 60 to 70 percent of human patients.

By printing multiple lung airways — or any other afflicted organ — from a human patient and testing drugs on them, pharma companies can bypass the ethically challenged practice of testing on animals and proceed to human clinical trials with greater confidence the drugs will actually work, according to Wadsworth.

This is done routinely in experiments with animals and occasionally with human patients undergoing neurological treatment.

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

A clinical trial to evaluate whether the ointment can treat antibiotic resistant infections in human patients is scheduled for 2018.

«I really hope,» she says, «that our studies will one day translate into helping human patients with dementia.»

By correlating osteoarthritis in living birds with their known behaviors, Rothschild hopes to learn more about the causal factors than he ever could from his human patients.

At much higher doses, benzodiazepines treat epilepsy and anxiety in human patients now, including those with autism.

These antianxiety drugs «are known to be safe, and we are using them at very low levels here,» study author Scheuer notes, adding he is not concerned about human patients receiving low doses of antianxiety drugs off - label.

«I don't think there are any human patients who walk backwards,» says Esther Becker of the University of Oxford, who led the team that investigated the mice (Proceedings of the National Academy of Sciences, DOI: 10.1073 / pnas.0810599106).

In the brain, his FFI mice develop neuronal loss in the thalamus and his CJD mice experience spongiosis in the hippocampus and the cerebellum, reflecting the damage seen in the brains of human patients.

A medical doctor (of human patients), Rothschild is often sought out these days by paleontologists for his observations about the diseases revealed in bones (the dinosaur kind)-- and the subsequent deductions about how these long - extinct creatures might have lived.

It works in cell studies and in mouse studies, but so far has proved frustratingly ineffective in human patients.

The findings may one day help researchers create better skin transplants for human patients with severe burns or skin diseases.

«Data from this study serves as rationale to now include dogs with spontaneous cancers in the advancement and optimization of PMed for human patients,» according to the study, Prospective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating personalized medicine (PMed) trials.

Besides its potential application in human patients, the newly developed skin tissue also could be used as an alternative to testing cosmetics on animals, the researchers said.

Prior to the new study, researchers had already developed a more basic type of skin substitute that had been used successfully in human patients, said Takashi Tsuji, a team leader at RIKEN Center forDevelopmental Biology in Japan.

Overuse of drugs on human patients and farm animals has helped fuel the rise of such drug resistance.

However, the therapy hasn't translated as well for human patients.

This is the finding of a study in both mice and human patients led by researchers at NYU Langone Medical Center and published online June 9 in the journal Cell.

By promoting DNA demethylation, high - dose vitamin C treatment induced stem cells to mature, and also suppressed the growth of leukemia cancer stem cells from human patients implanted in mice.

Pancreatic tumors taken from human patients also carried the enzyme - producing bacteria.

«We also confirmed that human patients with a missing or malfunctioning DNASE1L3 gene had an abundance of circulating DNA and developed antibodies to it, and that such antibodies were also present in most forms of lupus,» says Reizis.

The finding, reported in next month's issue of Nature Medicine, raises new questions about whether people could contract exotic diseases if animal organs become routinely transplanted into human patients.

«Gene variants modifying Huntington's symptom onset may lead to new therapeutic strategies: Genome - wide association analysis identifies sites associated with earlier - or later - than - expected symptom appearance in human patients.»

«Our approach does not rely on model systems but on DNA samples and clinical data from human patients.

Those false lines were used in the early trials of two drugs that were later tested in human patients with thyroid cancer.

To that end, in collaboration with the University of Zurich and MD Anderson Cancer Center, the researchers tested melanoma tumor samples from human patients undergoing treatment with the same targeted therapies.

In one small study in Japan, human patients with mild cognitive impairments showed significant improvement when given the mushrooms in powdered form.

They found that, within the first three days of injury, fish in the concussion group were slower to find a school of fish with which they previously swam, a measure of spatial memory which is impaired in other animal models of concussion and human patients.

«The rules, whether to protect human patients and research animals or prevent financial conflicts of interest, are often well - intentioned, academic officials say,» wrote Malakoff Monday in another After Election 2014 post.

Previous clinical trials have evaluated the efficacy, safety and tolerability of CIP on human patients.

Having an accurate, predictive model in mice is a proof - of - principle that such a model could also work for human patients in a hospital setting.

Horvath and Tell's research is the first reported study to compare breast cancer subtypes and gene expression patterns associated with STAT3 in the tumors of human patients.

Given that in humans HTR7 is also expressed in the neurons that innervate the skin, this new gene may well be responsible for itch in human patients taking antidepressants.

They waited until mice had had an EAE attack, akin to a flare - up of MS in human patients, and then administered Del - 1.

«The next step is to test tumors from more human patients and see how the results compare to the response that the patients have to chemotherapy,» said Walsh.

The most popular «Trojan horses» used to smuggle genes into human patients are modified retroviruses.

Next up: the team plans to study whether human patients with early stage Alzheimer's or a mild cognitive impairment experience this same nonconvulsive seizure activity.

They created inflammation in the temporomandibular joints of the mice, and then measured bite force exerted by the mice to assess jaw inflammation and pain, similar to how TMJD pain is gauged in human patients.

Studies of IBD are typically performed using cell culture experiments or animal models, which don't mimic the precise conditions that occur in the gut of human patients.

«These results are especially exciting because they show that we can take findings in the mouse and possibly apply them at the human patient population,» said Koenig.

Just as the technique restored kidney, muscle, and insulin - producing function in the mouse models, he sees a future for rejuvenating neuronal populations, maybe even one day in human patients.

Animal studies have suggested that overactivation of TLR7 plays a role in lupus, and a gene variant that increases expression of the receptor has been associated with increased lupus risk in human patients.

«The new model enables studies of the complex interactions between host cells, mucus production, and gut microbes in a system that closely mimics the situation in human patients,» Dawson said.

Hair thinning in a human patient and mouse with inherited loss of function mutations in WNT10A is shown.

«Our eventual goal is a clinical trial in human patients.»

«By analyzing mice with the WNT10A mutation, as well as tissues from human patients with WNT10A mutations, we found that WNT10A regulates the proliferation, but not the maintenance, of stem cells in hair follicles,» said Sarah Millar, PhD, vice chair for Basic Research in the Department of Dermatology.

«Our studies took us back and forth between human patients and our mouse model,» said Millar.

The researchers are now testing this approach in mice, and they envision that eventually the technology could be adapted to deliver the CRISPR components to treat infections or remove other unwanted bacteria in human patients.