Sentences with phrase «many immunosuppressant»

Elion also discovered azathioprine, an immunosuppressant that made it possible for people with weak immune systems to receive organ transplants.

After suffering from the terrible side effects of steroids, antibiotics, and immunosuppressant drug therapy, I decided to do some research of my own and I soon discovered that my symptoms could be controlled simply by the food I put in my body.

I was diagnosed with Ulcerative Colitis when I was 14 and after 6 years of getting ill (every 3 months after I stopped smoking) I went onto an immunosuppressant — Imuran.

But heavy use of immunosuppressant drugs weakened her and she succumbed to cancer in April at the age of 49, the BBC's Hugh Schofield in Paris...

Almost all of the patients with melanoma were white and they were more likely to be taking the common immunosuppressants cyclosporine or sirolimus than those without melanoma.

Commonly used immunosuppressant drugs prevent rapid - onset, acute GVHD but not persistent, long - lasting, chronic GVHD, which may cause severe disability and death.

In humans, Lagasse is banking on immunosuppressant drugs to prevent rejection.

Rapamycin, an antibiotic and immunosuppressant approved for use about 15 years ago, has drawn extensive interest for its apparent ability — at least in laboratory animal tests — to emulate the ability of dietary restriction in helping animals to live both longer and healthier.

Currently, there are no targeted therapies for affected children, who are usually treated with topical steroids and, in severe disease, with immunosuppressant drugs.

The most promising drug so far has been rapamycin, an immunosuppressant often used in organ transplants that's been shown to extend the life span of mice.

Sutures across the implanted cornea temporarily held it in place, and the recipients were put on immunosuppressant drugs for six weeks to prevent it being rejected.

The drug works faster than other immunosuppressants, and so carries less risk.

Rapamycin is an immunosuppressant drug which can be used to help prevent organ rejection after transplantation.

Although immune tolerance can occur — in rare cases, transplant recipients who stop taking immunosuppressants have not rejected their foreign organs — researchers don't have a clear picture of what is happening at the molecular and cellular levels to allow this to happen.

Rapamycin, which is an inhibitor of the mammalian target of rapamycin (mTOR) signaling pathway, has a variety of cellular functions and is known to possess both immunosuppressant and anti-tumor properties.

All 10 patients who received the CTL119 cells experienced mild cytokine release syndrome (CRS), a known potentially lethal type of toxicity, within a few days after receiving their infusions; however, none required treatment with tocilizumab, an immunosuppressant drug that blocks the effects of the inflammatory cytokine IL - 6.

And there is a big roadblock to testing drugs designed to induce tolerance: It is hard to know if they work unless immunosuppressant drugs are withdrawn, and that would risk rejection of the transplant.

Engineered new tissues can not only help patients avoid the need for an organ donation, but also the need for the recipient to take immunosuppressant drugs.

«However, as immunosuppression drugs required for transplantation can have significant adverse side effects, the treatment only makes sense for people who have frequent severe hypoglycemia despite optimal diabetes management, or for those already on immunosuppressant drugs for a kidney transplant, a group being studied in another Phase 3 trial.»

What changed the scene was an immunosuppressant molecule called cyclosporin, developed by researchers at Sandoz, the Swiss pharmaceutical company.

Inhibitory control Other strategies being pursued to prevent the formation of inhibitors of clotting - factor therapy include immunosuppressants and drugs that deplete specific immune cells.

What's more, any whole organ transplant will for now require a cocktail of immunosuppressant drugs that could leave patients vulnerable to infections.

Working first in people with perfectly immune - matched siblings and then with partially mismatched donor - recipient pairs, the researchers showed that the majority of individuals could achieve stable kidney function and successfully wean off of their immunosuppressants with few problems — in one case for up to nine years.

«I do not believe such a large number of transplants is likely with poorly tolerated organs that need to be beaten down with immunosuppressants.»

Bacteria of the order Actinomycetales synthesise antibacterial agents such as erythromycin, the anticancer drug doxorubicin, and immunosuppressant and antiparasitic compounds.

In fact, in the 18 ASD cases observed in offspring of lupus mothers with public drug coverage, none of the children were exposed to antimalarials, antidepressants, or immunosuppressants during pregnancy.

Some naturally - occurring peptides are already used as drugs, such as the immunosuppressant ciclosporin, but researchers could open up a world of pharmaceutical opportunity if they could design and synthesize peptides.

The sugar glucosamine works as an immunosuppressant in mice, and xylitol (a sugar alcohol) can prevent ear infections in kids.

That raised an intriguing question, because one of the few things scientists already knew about cyclophilin A was that it is the target of a powerful immunosuppressant drug, cyclosporin A.

Nine patients were treated with tocilizumab, an immunosuppressant drug that blocks the effects of the inflammatory cytokine IL - 6, which have been found to spike during the most robust phase of the engineered cells» expansion in the body.

Following a tissue graft transplant — such as that of the face, hand, arm or leg — it is standard for doctors to immediately give transplant recipients immunosuppressant drugs to prevent their body's immune system from rejecting and attacking the new body part.

Titus says that the way the cells were developed means recipients don't need immunosuppressants.

Current antifungals also have a narrow spectrum of activity, and some interact with other drugs such as chemotherapy agents and immunosuppressants.»

He advocated widespread use of these immunosuppressants, and because of these drugs, the number of transplants has grown every year for the past several decades; in 2005 surgeons performed 28,107 transplants of the kidney, liver, pancreas, heart, lung and intestine, according to the United Network for Organ Sharing.

They treat with a powerful immunosuppressant three weeks before surgery, then inject donor cells into the patient and follow with low doses of drugs until the operation.

Immunosuppressant drugs can have severe side effects, increasing the risk of heart disease, infection, cancer and diabetes.

«Cancer treatment for transplant patients discovered: Letter notes combination of steroids and immunosuppressants, combined with immune checkpoint inhibitors helps prevent organ rejection in kidney transplant patients undergoing cancer treatment.»

In 1992 Starzl observed something that convinced him to rethink the way immunosuppressants are used.

All six had cytokine release syndrome (CRS), from which they recovered after treatment with tocilizumab, an immunosuppressant drug that blocks the effects of the inflammatory cytokine IL - 6.

Of the eight recipients, five were completely off immunosuppressants, with no sign of GVHD, within a year, and their kidneys have continued to function well for an additional 18 months.

Of 10 patients who got kidneys from genetically mismatched donors, which typically leads to organ rejection more often than matched transplants, seven successfully came off immunosuppressants.

«At the moment, the main treatments for non-infectious uveitis are steroids or the immunosuppressant cyclosporine,» explains Dr Calder.

Warshaw said patients who get immunosuppressants can respond very differently to regular cancer treatments.

Patients who undergo transplants are typically put on immunosuppressant medication to help their bodies accept the new liver.

The chemical rapamycin is used clinically as an immunosuppressant and as an anti-cancer agent that works by inactivating a protein named TOR (Target Of Rapamycin).

After running thousands of drugs through the supercomputer, they found that methyldopa not only blocked DQ8, but it didn't harm the immune function of other cells like many immunosuppressant drugs do.

(anti-CD25, Zenapax) An immunosuppressant, this drug lowers the body's immune response.

(ATG, Atgam, Thymoglobulin) ATG is an immunosuppressant, a drug that lowers the body's immune response.

Cyclosporine is used along with antithymocyte globulin (ATG), another immunosuppressant, for treating aplastic anemia and some other forms of bone marrow failure.

Exclusion criteria included: significant current illness as indicated by history, examination and / or laboratory testing including complete blood counts, alanine aminotransferase (ALT) and serum creatinine; previous immunization with a rabies vaccine or any experimental vaccine; chronic use of immunosuppressants; receipt of blood products during the previous 6 months; and allergy to substances present in the vaccines.