Sentences with phrase «many key genes»

Some researchers have proposed deleting or disabling key genes that are required for early embryonic development.

Study Dispels Theories of Y Chromosome's Demise: Stripped - Down Chromosome Retains Key Genes for Fertility

We observed strong modulation of key genes involved in lactose synthesis and insulin signaling.

Changes in key genes clearly define four previously unknown conditions within the umbrella diagnosis of schizophrenia, according to a study led by researchers from NYU Langone Medical Center published online April 28 in EBioMedicine, a Lancet journal.

In recent years, clock researchers have uncovered some of the gears and springs that keep this circadian timepiece running, largely by identifying a handful of key genes in organisms from bread mold to mice.

Upon joining the lab, Lee chose a high - risk project — «it sounded like more fun,» she says — aimed at determining whether a key gene in the yeast cell cycle, cdc2, was also present in human cells.

The team sequenced the gene that codes for the NaV1.7 channel in mole rats, and compared it with SCN9A — a key gene in the human version of the channel.

A second key gene, SLC39SA13, codes for a zinc transporter that helps nerve cells to «decide» whether or not nerve impulses are amplified of dampened.

One key gene encodes the making of a receptor called TREM2, a docking site for molecules on the surface of microglia and other innate immune cells.

Researchers have found that the expression of three key genes drops during the fasting - mimicking diet.

It was assumed that these fish became blind because mutations disabled key genes involved in eye development.

«U1 dysfunction might produce changes in RNA processing affecting many genes or specific changes affecting a few key genes that are important in Alzheimer's,» Lah says.

Tattersall explains how epigenetic effects on key genes cascade to produce radical morphological changes in an eye blink, and why our unusual thinking style, far from being the perfected product of long - term selective pressures, was bootstrapped out of existing abilities barely 100,000 years ago.

In addition to its effect on the insulin pathway, the let - 7 microRNA appears to drive these metabolic and functional changes by acting on other key gene regulators.

Interestingly, the let - 7 family of micro RNA affects several key genes that regulate glucose metabolism, called the PI3 / AKT / insulin pathway.»

By isolating a key gene in the remaining plants, scientists found the receptor that aids in plant development and helps repair a plant during major events.

According to Beg, NF - κB proteins regulate key genes involved in immune response, inflammation, cell death and cell growth.

Alternatively, epigenetic changes — changes in the way genes are switched on and off — influencing key genes, induced by sex hormones, may be responsible.

«It's really cool that they can pinpoint the acquisition of key genes that allow the movement of this bacteria into fleas,» says evolutionary geneticist Hendrik Poinar of McMaster University in Hamilton, Canada, who was not involved with the study.

The authors conclude that the study of marine mammals is just the first demonstration of this new evolutionary approach, and is versatile enough to be applied to many other emerging questions concerning key genes involved in the diversity of life.

In 1972, he devised a now widely used formula, Nei's standard genetic distance, which compares key genes of different populations to estimate how long ago the groups diverged.

Further, Shankman identified a key gene, Klf4, that appears to regulate these transitions of smooth muscle cells.

They had identified a key gene in the beet cyst nematode that makes the cytokinin hormone.

This caused two key genes normally activated solely on the left side of the body to be expressed on the right side, the team reports in the 4 July issue of Nature.

Now, Mitchum's team is trying to find how this key gene might work differently in other nematode types, like root - knot nematode as part of a new National Science Foundation grant.

Sifting through this mountain of data, the scientists found three key genes that were altered by the NOTCH1 mutation and also acted as master regulators, turning off the critical pathways that normally prevent inflammation and calcification.

With the acquisition of a number of key genes and lipids from a bacterial symbiont, it would be possible for Loki - type cells to evolve a primitive membrane trafficking machinery and compartmentalization.»

By flipping on three key genes in cells from the lower stomach, scientists may have engineered a viable replacement for those beta cells.

Kriegstein notes that the hunt will likely commence for small molecules capable of activating the key genes.

To find the new mutation, the scientists looked at five key genes that play a role in phototransduction, or the process by which light signals are transmitted through the eye to the brain.

The DNA variation observed at key genes revealed a large diversity of coat coloration patterns within Scythian horses, including bay, black, chestnut, cream and spotted animals.

Although the experiment would be very difficult to pull off in a non-model organism, «that would be the real kicker to demonstrate that that is the key gene for it,» he said.

Some of the letter variants were inside a gene, while others were near key genes.

«In mammals, in the absence of haploid cells, other approaches have been used to identify key genes, such as interfering RNA, but they are sub-optimal methods.

The researchers found that MYC may affect circadian rhythm and metabolism by promiscuously binding to promoter regions in key genes for maintaining these daily cycles.

Rhythmic expression of key genes is essential for maintaining proper timekeeping of the body's clock.

Early in human evolution, our ancestors switched off two key genes.

Indiana University scientists have discovered the first known instance of a plant or animal lacking several key genes involved in energy production in cells.

«We're now trying to track down which the key genes are, and which the key pathways are,» she says.

During the 1990s, a team led by Jeffery Taubenberger at the Armed Forces Institute of Pathology in Washington, D.C., sequenced key gene fragments of the 1918 flu strain, recovered from frozen victims found in the Alaskan permafrost and in archived autopsy material.

In addition, researchers came up with a list of the activity of 275 key genes that can present reprogramming results.

His lab initially tried making the virus more transmissible in ferrets — virologists» preferred animal model — by mutating key genes.

Such key genes likely would serve as signposts to biological pathways important to normal and disordered dental development.»

The tip of this ear of corn is growing abnormally, but provided scientists with information about how to tweak expression of a key gene to boost yield.

«Key gene in early brain regeneration in planarians described by scientists.»

Therefore, egr - 4 is a key gene in early brain regeneration.

Nevertheless, our data clearly point to ANKRD55 as the key gene in this area.

In a separate paper, virologist Mark Gibbs and his colleagues at Australian National University in Canberra report that a key gene in the virus that caused the 1918 pandemic is part pig, part human.

In recent years, scientists have tried to turn fast - growing bacteria into chemical factories by transplanting the key genes responsible for the exotic chemistry.

«Even more importantly, the differences involved key genes and pathways that are designed to be blocked by new RA treatments.