Sentences with phrase «many key regulators»

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The missing link turns out to be a protein called sirtuin 1 or SIRT1, which is also a key regulator of aging.

Partly related to its function as a regulator of the immune response, the NF - kB pathway is also a key regulator of cancer progression.

But in addition to these factors, Hunt, who won a share of the 2001 Nobel Prize in physiology or medicine (along with Leland Hartwell and Paul Nurse) for his discovery of cyclin, a key regulator of the cell cycle, emphasizes early independence and playfulness.

The key regulator they identified were the RFX transcription factors.

This led me to enter the field of developmental and cell biology, and to eventually discover cyclin as a key regulator of the cell cycle.

In particular, they are key regulators of energy and glucose.

The team has identified the protein kinase MSK1 as a key regulator of dormant or latent metastases.

The Eischen group focused on the role of long non-coding RNAs (lncRNAs), which have emerged as key regulators of genes.

«Key regulator in pacemakers of our brain, heart discovered.»

The researchers found that mutations to a gene called ATF6, a key regulator of the unfolded protein response, can lead to achromatopsia, a hereditary visual disorder characterized by color blindness, decreased vision, light sensitivity, and uncontrolled eye movement in children.

The new findings come on the heels of a series of pivotal discoveries made by Yuan and colleagues over the last decade revealing RIPK1 as a key regulator of inflammation and cell death.

«In this study, we show that PVT1 can be a key regulator of MYC protein, which can shift the paradigm in our understanding of MYC amplified cancers.»

And when researchers experimentally increased deltaFosB levels in normal mice, calbindin expression was suppressed and the animals» memory deteriorated, demonstrating that deltaFosB and calbindin are key regulators of memory.

Researchers from the Vetmeduni Vienna have now discovered that NK cells can switch and promote tumor growth, with STAT5 acting as the key regulator.

Using newly discovered information, the researchers made significant advances in developing a family of drug candidates that target a receptor known as peroxisome proliferator - activated receptors gamma (PPARγ), a key regulator of stem cells controlling bone formation and bone resorption and a master regulator of fat.

They also found that a protein called Seven in absentia 2 (Siah2) is a key regulator of the turnover of a well - studied, clock nuclear protein called RevErbα on a 24 - hour cycle.

To start the process, both the key regulator Atg1 as well as the «waste» to be discarded are separately brought to the precise location where the waste is packed into cellular «garbage bags.»

Their results, the researchers conclude, identify IL - 28B as a key regulator of the immune response to influenza vaccination.

A key regulator of alternative splicing is the Rbfox family of proteins, which are enriched in neurons and previously were linked to neurodevelopmental disorders, including autism, schizophrenia, and epilepsy.

«The complete protection from obesity and metabolic dysfunction in the study animals, without any differences in appetite or physical activity, suggests that p75 NTR is a key regulator of fat burning.»

Previously, Jonathan Tilly, a reproductive biologist at Massachusetts General Hospital in Boston, found a striking correlation between high levels of a protein called Bax (a key regulator of apoptosis) and cell death in healthy ovaries.

«New key regulator of acquisition of immune tolerance to tumor cells in cancer patients.»

A key regulator of myeloid derived suppressor cells and the possibility of reverting its effects on immune fucntion

In 2001 he was jointly awarded the Nobel Prize for Physiology or Medicine for discoveries of key regulators of the cell cycle.

The study, published in Nature Communications today, focused on protein kinases, enzymes that are key regulators of cellular processes.

CR6 - interacting factor 1 is a key regulator in Aß - induced mitochondrial disruption and pathogenesis of Alzheimer's disease.

Furthermore, CD47 is known to be a key regulator of tissue homeostasis, and is also involved in a variety of diseases ranging from atherosclerosis to cancer.

Finally, these oxidants induce PGC1alpha, a key regulator of mitochondrial metabolism, to increase mitochondrial activity and energy production.

We discovered STK38 as a novel binding partner of Beclin1, a key regulator of autophagy.

Hsiou - Chi Liou and colleagues find that c - Rel, a lymphoid - specific member of the NF - kappaB / Rel family of transcriptional factors, is essential for B lymphocyte survival and cell cycle progression, [i] and that it is important for inducible cytokine and cytokine receptor expression and a key regulator of early activation and proliferation in T cells.

Additionally, the RBR protein HOIP forms the central unit of the linear ubiquitin chain — assembly complex (LUBAC), which has emerged as key regulator of the NF - κB pathway.

Yvonne Gloor (Walch - Solimena, MPG)-- «The Arf GTPase exchange factor sec7p interaction network: unraveling the crosstalk between key regulators of golgi transport» (2007)

In this presentation, special emphasis will be given to the role of Ca2 + handling as a key regulator of (i) muscle weakness and (ii) beneficial adaptations observed after high intensity interval training.

In rice, Oryza sativa HOMEOBOX1, a key regulator of meristem maintenance similar to kn1 from maize, controls local BR accumulation by directly targeting and upregulating genes encoding BR catabolism and conjugation enzymes (Tsuda et al., 2014).

Delous M., Yin Ch., Shin D., Ninov N., Debrito Carten J., Pan L., P. Ma T., Farber S., Moens C., Stainier D.Y.R sox9b is a key regulator of pancreaticobiliary ductal system development.

He served as a member of the graduate faculty in the Department of Molecular Biology at Princeton University and spent 10 years at NIH where he madesignificant contributions to the discovery of a class of proteins known as tyrosine kinase oncogenes as key regulators of the immune system.

LKB1 acts as a key regulator of cell polarity as well as energy metabolism partly through the activation of the AMP - activated protein kinase (AMPK), a sensor that adapts energy supply to the nutrient demands of cells facing situations of metabolic stress.

Hypoxia - inducible factors as key regulators of tumor inflammation.

One mechanism is protein synthesis by key regulators such as S6 kinase (S6K).

We identified homozygous inactivating mutations in RAB3GAP, encoding RAB3 GTPase activating protein, a key regulator of the Rab3 pathway implicated in exocytic release of neurotransmitters and hormones, in 12 families with Micro syndrome.

«IL - 28B is a key regulator of B - and T - Cell vaccine responses against influenza» by Adrian Egli et al. published in PLOS Pathogens on Thursday 11 December 2014.

As shown in 1A, similar to hESCs, hNSCs express high levels of SOX2, which is considered a key regulator of pluripotency [19], and NESTIN, a protein specific to NSCs [21]--[23].

So SOCS3 is actually a key regulator that has been found to inhibit leptin signaling, and cause so - called leptin resistance.

The research demonstrates that bioactive lipids have the ability to regulate inflammatory immune cells in the retina, key regulators of the angiogenic process in this disease.

Together, our results identify SCYL1 as a key regulator of motor neuron survival, and Scyl1 -LRB-- / --RRB- mice share pathological features with many human neurodegenerative conditions.

Instead of waiting for the program to end, we spent the past decade showing that HARs are key regulators of embryonic development.

So, therefore, insulin is a key regulator of this pathway as well.

The protein is a key regulator of lysosomal exocytosis.