Sentences with phrase «many kinds of tumors»

Even with the cancers that are further along in their immunotherapy responses, a «certain fraction of those kinds of tumors, I don't know we'll ever cure,» Allison says.

So if researchers think that an individual drug for, say, chronic myeloid leukemia might work against a different kind of tumor because the two illnesses share similar biological underpinnings, they have to conduct a whole new clinical trial and go through the approval process all over again for the second condition.

However, when the researchers switched on KRAS in the preclinical models, an entirely different kind of tumor formed, called angiosarcoma.

Put simply, the pattern of microRNA genes turned on in one kind of tumor was entirely different from the pattern in another kind of tumor, and entirely different again from that seen in healthy cells.

One reason for this, explains Hai - Hui (Howard) Xue, MD, PhD, UI professor of microbiology and immunology, is that there are two kinds of tumor cells — bulk leukemia cells that can be killed by TKI drugs, and a subset of cells called leukemia stem cells, which are resistant to TKIs and to chemotherapy.

But while checkpoint blockade has had some striking successes, the therapy has almost no effect on some of the most lethal kinds of tumors.

It's a primary brain cancer, which means that it originates directly from the brain, and it's not coming from a different kind of tumor located in another part of the body.

Certain kinds of tumors have been found to be more aggressive and associated with less than favorable prognoses compared to others.

Moreover, while surgeons are able to operate to remove certain kinds of tumors, some disorders are located in the brain stem, amongst nerves, making surgery impossible,» added collaborator and senior author Anne - Sophie Carret.

On a brighter note, not all breast cancer patients have the kind of tumor microenvironment in which pre-op chemo can promote metastasis.

«At some point, if we get favorable results, we could apply it to other kinds of tumors.

The tumor predates other evidence for these kinds of tumor by well over 100,000 years.

The production of vaccines involves developing antigens that can fight specific kinds of tumors.

Some kinds of tumors produce a hormone that can cause your body to make too much cortisol.

But when cortisol remains in the body two or more days, it affects the body's immune system by reducing its T - cell count, impairing memory, and reducing Natural Killer (NK) cells that fight viruses and even some kinds of tumors.

A biopsy is the only way to determine what kind of tumor your dog has.

We see other kinds of tumors as well, but they are much less common — lung tumors, brain tumors, nasal tumors, liver tumors.

Many kinds of tumors will metastasize to the lungs, so this is something that needs to be checked out immediately.

A biopsy may be indicated to rule out a certain kind of tumor called inflammatory mammary carcinoma, as surgery is generally not recommended for this tumor type

Additionally, veterinarians usually want to take a fluid sample from the lymph nodes to look for cancerous cells and will perform a biopsy of any oral mass to determine exactly what kind of tumor is present.

Studies show spayed and neutered cats lead healthier and longer lives, and the procedure virtually eliminates the chances for certain kinds of tumors.

Common conditions of pet ferrets include diarrhea, intestinal foreign bodies, parasites, heart disease, and various kinds of tumors.

Then there are some companies that take issue with any kind of tumor.

Not exact matches

BMS's drug, ipilimumab (Yervoy), was the first checkpoint inhibitor (a kind of cancer immunotherapy drug that essentially helps the immune system release its brake and go after tumor cells it might normally miss) to get approved in the US in 2011 for melanoma.

«This approval will open the floodgates for these kinds of therapy to be used in many different leukemias, lymphomas, solid tumors, myelomas,» Dr. Prakash Satwani, a pediatric hematologist - oncologist at Columbia University Medical Center, told Business Insider.

Kaalvoet - Kind, I felt nauseated just reading of someone telling a mother her child has a brain tumor because of the mother's sin.

Iron Gall ink is so named because it is traditionally made from oak galls, a kind of arboreal tumor.

With his kind of cancer, there were no tumors to X-ray, no reliable way to chart the course of the disease.

Just months after finding out he had metastatic cancer, former President Jimmy Carter announced this weekend that his doctors have said he no longer needs cancer treatment thanks in part to a groundbreaking new kind of medication that trains the immune system to fight cancer tumors.

«There are certainly challenges to overcome for clinical application of this kind of immunotherapy, but the newly published data are an important milestone in immunotherapy targeting solid tumors that have eluded other treatments.»

The system, says Brahmer, provides a kind of «handshake» or connection between receptors on immune cells, called PD - 1, and their sister - proteins on tumor cells, called PD - L1.

(Mackenzie notes that it shouldn't be a problem for her strategy, because she plans to use the same kind of cells as bone marrow transplants, which haven't caused tumors.)

«Each tumor type may acquire a unique set of capabilities that may provide tumor - specific growth and survival advantages, which may need to be determined for each kind of cancer.

«About five percent of people have some kind of cartilage tumor in their bones, and in most cases it's because the growth - plate cartilage cells weren't fully replaced by bone tissue,» Alman said.

Glioblastomas in lab dishes and mouse brains are fakes, little Potemkin villages that everyone thought were faithful replicas of human glioblastomas but which, lacking tumor stem cells, were nothing of the kind.

To streamline this process, Uhlén's team has created standardized arrays containing microscopic samples from 48 kinds of normal human tissue and 20 types of tumors.

A 2013 paper in the same journal reported excellent vocal outcomes for the first 92 treated patients, but neither paper included the kind of follow - up data required to confirm the treatment's long - term effectiveness in curing the tumors.

One adaptation to this fortunate reality is that rather than using overall survival (OS) as the measure of a drug's success, many clinical trials now use a kind of midpoint, namely progression - free survival (PFS)-- the time that it takes for a tumor controlled by the trial's medicine to restart its growth.

Unfortunately, however, in most cases a kind of resistance develops: Eventually, the cancer cells no longer respond to the drug and the tumor spreads again.

«In a tumor, similarly, regions that develop these kinds of shapes may activate cells that can then escape and form more tumors.

They then conducted biochemical analyses to identify neuroligin - 3, confirm that the protein could stimulate tumor growth in cultured samples of several kinds of human high - grade gliomas and study which signals the protein uses within glioma cells to promote their growth.

In the largest study of its kind, researchers led by the University of Pennsylvania School of Nursing have investigated the caregivers of 186 mothers to childhood brain tumor survivors aged 14 - 40 whose care needs last long into adulthood.

Tracking sequence changes over time could also provide a kind of early warning system to identify the emergence of an aggressive form of the cancer by providing a real - time window into tumor evolution.

These tumors might yield to a new kind of drug known as a PARP inhibitor that kills cancer cells by hijacking the cell's ability to mend DNA breaks.

Researchers leading the largest genomic tumor profiling effort of its kind say such studies are technically feasible in a broad population of adult and pediatric patients with many different types of cancer, and that some patients can benefit by receiving precision drugs targeted to their tumors» mutations or being enrolled in clinical trials.

In the first clinical proof of its kind, a drug has dramatically shrunk cancerous tumors by disrupting a key genetic pathway.

But only about half of melanoma victims have these tumor - fighting T cells, and the cells are very scarce in other kinds of cancer.

«We kind of had this wild idea that because these tumor cells are just pouring [out microvesicles], maybe we can actually see it in the blood,» Breakefield says.

When Pandolfi and colleagues increased the levels of saturated fats — the kind found in fast food cheeseburgers and fries — in the animals» diet, the mice developed aggressive, metastatic tumors.

Generally tumors that happen in older people have more mutations, and for other kinds of cancers the number of mutations has been found to be related to the response to immunotherapy: Older people can have tumors that have more mutations and sometimes they can be more responsive to immunotherapy but, really, it's just luck; there's no hard - and - fast rule about age being related to response to immunotherapy.