Sentences with phrase «many kinesin»

Although scientists have found dozens of different kinesins, each with its own job, they know little about how the minimotors work.

We demonstrated that β - arrestins mediate the activity - dependent interaction of Smo and the kinesin motor protein Kif3A.

Lawrence Goldstein and his colleagues at the University of California, San Diego (UCSD), reasoned that if they could find a molecule that halts kinesin function, they could learn more about when and how they work — and possibly design drugs to disable specific kinesins.

Cellular motors called kinesins drag cargo within cells — they tug recently separated chromosomes to opposite ends of a dividing cell, for example.

The researchers found that AS - 2 binds strongly to the kinesin motor, preventing it from sticking to a cell's monorails — that is, traveling along microtubules.

When a kinesin protein reaches the end, it detaches from the filament taking the tubulin to which it is bound with it.

Things like HIV protease inhibitors, for example, or Kinesin - tubulin interactions do not appear to be covered by any of the subheads listed under these two headings.

This particular active material, originally developed at Brandeis University, borrows elements of cellular machinery, with bundles of rod - like microtubules forming the filaments, kinesin motor proteins acting as the engines, and ATP as the fuel.

The worm - like structures are microtubules driven by kinesin motor proteins.

Members of the kinesin superfamily of motor proteins are essential for mitotic and meiotic spindle organization, chromosome segregation, organelle and vesicle transport, and many other processes that require microtubule - based transport.

Proteins called kinesins, for example, are natural nanomotors that support cellular functions such as mitosis (the chromosomal process that creates two nuclei from one parent nucleus) and meiosis (when the number of chromosomes per cell is reduced by one half).

A compound, adociasulfate - 2, was isolated from a marine sponge, Haliclona (also known asAdocia) species, that inhibited kinesin activity by targeting its motor domain and mimicking the activity of the microtubule.

His team found that, from its vantage point at the minus - end of an existing microtubule, Kinesin - 14 attaches to a second protein that is bound to the plus end of a growing microtubule.

A team of researchers led by Alipasha Vaziri, an associate professor and head of the Rockefeller's Laboratory of Neurotechnology and Biophysics, has found that a molecular motor, called Kinesin - 14, helps to guide the formation of a new microtubule along an existing one, and so directs the formation of bundles.

«Cell division: Physical forces involved in creating the mitotic spindle probed: The motor protein kinesin - 5 appears to help organize spindle's filaments by pushing or slowing them.»

The researchers described how a protein called kinesin - 5 acts like a kind of molecular motor to help organize the mitotic spindle.

By shining a laser light on a microscopic - sized plastic bead attached to a pair of microtubules linked by kinesin - 5 molecules, the team tracked their activity and discovered that this force is a function of the microtubule overlap — the longer the overlap, the greater the force.

The study shows it takes a lot of counterforce to slow down a determined kinesin.

The force exerted by kinesin - 5 in that process hasn't been previously measured.

To do the sorting, kinesin - 5 can link two anti-parallel microtubules, pushing them in opposite directions, so their minus ends move away from the spindle's center and toward the spindle's poles.

The base simulation will allow researchers to test more kinesins that move cargo from the nucleus to the outer limits of the cell and, eventually, dyneins, larger and more complex proteins that move cargo toward the center.

Kinesins transform energy from the chemical ATP, or adenosine triphosphate, into mechanical action.

As many kinesin - 5 molecules work together directing microtubules, they become the governing force of the spindle formation.

The researchers found that the motor protein kinesin - 5 (green) helps prepare the spindle by organizing its filaments, or microtubules, (red) by pushing them or acting as a brake.

«We believe that kinesin - 5 has the ability to coordinate the speed of microtubules and keep them from going too fast or too slow,» says Forth, likening the protein to a gear box in a car.

Kinesin - 5 has been identified as a target for drugs to treat cancers that involve uncontrolled cell division, such as colorectal cancer, Al - Bassam said.

It turns out these teammates barely register to the boss kinesin if they are more than 48 nanometers away.

«Kinesin - 5 structure opens cancer drug targets.»

Originally identified as a protein essential for mitosis in fungi, kinesin - 5 was first purified about 20 years ago by Scholey's lab who found that it is unusual because it has motor units at both ends, allowing it to link two microtubules and walk them past each other.

Other motor proteins, called kinesins and myosins, are much smaller and have specific functions, but dynein can turn its hand to a lot of different of functions,» Professor Knight said.

In this example, the leading kinesin (LK) carries most of the load, with motor heads (blue) activated by a neck linker (yellow) that connects to the stalk (red) and senses the presence of the cargo.

Each kinesin contains two «head» subunits, and each subunit contains two binding sites — one to grip and walk along microtubules and the other to bind ATP.

«The structure of kinesin - 5 is unexpected, and the implications are big — it allows us to target it, for example in various forms of cancer,» said Jawdat Al - Bassam, assistant professor of molecular and cellular biology at UC Davis, who led the project.

RESULTS: Here we report the identification of a de novo nonsense truncating mutation in one patient with SCZ, in kinesin 17, a synaptic motor protein.

Till Korten (Diez, MPG)-- «How Kinesin - 1 deals with roadblocks: biophysical description and nanotechnological application» (2009)

Functional analysis of human microtubule - based motor proteins, the kinesins and dyneins, in mitosis / cytokinesis using RNA interference.

Rene Schneider (Diez, MPG)-- «A novel parabolic prism - type TIR microscope to study gold nanoparticle - loaded kinesin - 1 motors with nanometer precision» (2013)

The Fragile Fiber1 Kinesin Contributes to Cortical Microtubule - Mediated Trafficking of Cell Wall Components.

A kinetoplastid - specific kinesin is required for cytokinesis and for maintenance of cell morphology in Trypanosoma brucei.

Molecular Basis for Specific Regulation of Neuronal Kinesin - 3 Motors by Doublecortin Family Proteins.

Inhibition of the motor protein Eg5 / Kinesin -5 in amyloid β - mediated impairment of hippocampal long - term potentiation and dendritic spine loss.

The human kinesin - 14 HSET tracks the tips of growing microtubules in vitro.

Regulation of endosomal membrane traffic by a Gadkin / AP -1 / kinesin KIF5 complex.

Kinesin - 1 and dynein at the nuclear envelope mediate the bidirectional migrations of nuclei.

CENP - meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila.

An orphan kinesin in trypanosomes cooperates with a kinetoplastid - specific kinesin to maintain cell morphology through regulating subpellicular microtubules.

Kinesins klp5 + and klp6 + are required for normal chromosome movement in mitosis.

Volker Bormuth (Howard, MPG)-- «Optimized optical tweezers to study the mechanics of kinesin - 8: stepping, slipping, protein friction» (2009)

Molecular Basis for Specific Regulation of Neuronal Kinesin - 3 Motors by Doublecortin Family Proteins % U http://www.sciencedirect.com/science/article/pii/S1097276512005503.

A genomic toolkit to investigate kinesin and myosin motor function in cells.