Sentences with phrase «many mouse strains»

For their experiments, the researchers created hybrids of two genetically distinct mouse strains with a fully sequenced genome, allowing gene variants to be clearly assigned to the maternal or paternal allele.

This suggested that obesity in both obese and db mouse strains resulted from a mutation in a single gene in each case.

His lab eventually sold mouse strains all over the country.

In addition, the Merck institute — a nonprofit foundation set up by the giant drug company — is pulling together a committee of six prominent biologists who will select 150 clones for development into mouse strains over the next few years.

«Until now, researchers used a mouse strain that is deficient in interferon — a signaling protein that heightens anti-viral defenses.

Currently, it takes up to 10 months — and as much as $ 100,000 — to develop a knockout mouse strain.

Barbara Rehermann and Stephan Rosshart first collected 800 wild house mice (Mus musculus domesticus) in the Washington, D.C., metro area, and compared their DNA and gut bacteria both with a lab mouse strain and with wild mice from all over the world.

«It also remains to be elucidated whether this phenomenon is particular for the mouse strain used in this study or is a more general phenomenon that also occurs in other genetic strains,» said Dr. Gerjo JVM van Osch, senior author of the Journal of Orthopedic Research article.

This infection is fatal in some mouse strains but not others.

Future research can evaluate if Isl1 is protective from ARHL and NIHL in other mouse strains.

Bautista, Brem, and collaborators sought out genes whose expression was correlated with itch behavior across genetically distinct mouse strains.

They observed that after allergic sensitization, some mouse strains generated large populations of MMC9 cells while other strains did not.

Researchers from the Centers of Disease Control and Emory University studied a mouse strain of Ebola that was adapted from a human strain.

There is a mouse strain that develops primary mammary tumors, but those tumors do not form metastases.

While trying to create better mouse strains for studying human diseases, she and other researchers may have inadvertently stumbled upon genes that render hybrids as dead ends.

«The diversity across these 40 mouse strains is as great as or greater than that of the entire human population,» Jackson geneticist Kenneth Paigen tells me, but within each individual strain the DNA is incredibly uniform.

By using pharmacological small molecule inhibitors as well as neutrophils from genetically modified mouse strains the team could identify essential receptor and signaling pathways involved in the nicotine - mediated activation of neutrophils.

From this screen, they recovered eight different mouse strains with structural and functional heart defects indicative of HLHS.

Using a specialized gene manipulation technique called chromosome engineering, researchers developed genetically engineered mouse strains in three separate iterations: MYC only, the rest of the region containing PVT1 but without MYC and the pairing of MYC with the regional genes.

In one mouse strain, they discovered that mutations in two genes, named Sap130 and Pcdha9, were required for HLHS.

In the new work, the researchers fed two common emulsifiers, CMC and polysorbate 80, to both a genetically susceptible mouse strain and wild - type mice — those without genetic mutations that would put them at increased risk of IBD or metabolic syndrome.

Enter a mutant mouse strain that is afflicted at a young age with many of the diseases common to older humans.

However, researchers have only limited possibilities to study what exactly happens when the protein is missing because it is very difficult for them to breed the necessary mouse strains.

Each mouse strain captures only a snippet of the human picture.

Neuroscientist Mark Geyer is a schizophrenia man by trade, always on the lookout for mouse strains to model the reality - twisting disease.

«We have demonstrated the significance of this link in a mouse model system, based on the use of a miR - 34a - deficient mouse strain that we had generated.

Another of Woo's experiments involved a PAH - deficient mouse strain developed by William Dove and colleagues at the University of Wisconsin in Madison.

Still, the genetic homogeneity of largely inbred mouse strains may be misleading when it comes to understanding human stem cells, cautions Peter Andrews, professor of biomedical science and co-director of the Centre for Stem Cell Biology at the University of Sheffield, U.K. «In the human, every embryonic stem cell that we're working with that comes from a different person is genetically different,» says Andrews.

We have tested this hypothesis by generating and analyzing a mouse strain that lacks the gene encoding the essential subunit of the N - methyl - d - aspartate (NMDA) receptor NR1, specifically in dentate gyrus granule cells.

To their surprise, many of the cells failed to form teratomas at all — similar to what the researchers saw when they transplanted ES cells from one mouse strain to another.

This system could be used in combination with hundreds of existing mouse strains that have been engineered to express known cancer genes, allowing researchers to study more thoroughly the interactions of multiple genes.

If interactions between IL - 15 and IL - 15Rα were to occur strictly as a secreted cytokine binding to a cell surface receptor, then similar exercise and muscle phenotypes would have been observed in both IL - 15Rα — KO mice and IL - 15 — KO mice, since ligand - receptor binding would have been interrupted in both of these mouse strains.

When the researchers repeated the challenge experiments in two different immune - deficient mouse strains, they found that HB36.6 can protect these mice as well.

They crossed a mouse strain that is highly resistant to cancer with a strain that is highly susceptible.

In the course of screening over 180 mutant mouse strains with a systematic battery of behavioral tests, Dr. Tsuyoshi Miyakawa and his colleagues found that mice with heterozygous knockout of the alpha - isoform of calcium / calmodulin - dependent protein kinase II (αCaMKII) exhibit behavioral deficits and other brain features consistent with bipolar disorder.

Fast EDL and slow soleus muscles from all mouse strains were dissected and transferred to oxygenated Ringer's solution for assessment of isometric force — generating capacity ex vivo.

It is now possible to introduce mice strains (known as «knockout mice») in which specific genetic modifications can be activitated at specific times, or in specific cells or organs.

Using the C57BL / 6J mouse, a mouse strain that can be infected by the A / Vietnam / 1203 / 04 H5N1 virus without adaptation, we show that this virus travels from the peripheral nervous system into the CNS to higher levels of the neuroaxis.

Celera announced it had completed the sequencing of four mouse strains in April 2001, and it sells the information — along with computer tools to analyze it — to businesses and universities.

The new mouse model employs a mouse strain called C57BL / 6, which is commonly used in disease research.

Abner, R.; Edwards, T.; Brunner, D. Pharmacology of Temporal Cognition in Two Mouse Strains.

To this aim we generated new conditional knockout mouse strains, which are currently analyzed to unravel the mechanism of a recently discovered unexpected protective role of TNFSF14 / LIGHT by our lab in an Inflammatory Bowel Disease (IBD)- like mouse model.

The unit provides genetic testing services using a combination of both microsatellite and single nucleotide polymorphism (SNP) panels for characterizing and selecting breeders in a wide variety of inbred mouse strains subsequently used for the generation of congenic animals.

New mutations also can be added to existing mouse strains that already carry desired mutations, reducing the time and costs to generate double and triple mutant mice.

Some mouse strains are only archived as knockout - first allele («tm1a allele»), but if users are interested in another allele which is not cryopreserved at EMMA, some EMMA nodes offer allele conversion as a service.

Next, they confirmed these results in a special mouse strain bred to express HIV / gp120 in its brain.

During the next five years, KOMP2 will transform the knockout mouse embryonic stem (ES) cells into adult mice for 2,500 lines of well - characterized knockout mice strains, and IMPC will create about 2,500 additional knockout mouse strains.

• Mouse whole genome scanning The unit offers microsatellite and SNP based Genome Scanning Services for gene identification projects, based on linkage analysis, offering coverage for a number of mouse strains (i.e. C57BL6, DBA2J, CBA, 129S6, 129P2), as well as bioinformatic analysis using suitable mouse genetic software.

The Mouse Molecular Technologies team provide high - throughput genotyping and characterisation of mutant mouse strains created either by targeted embryonic stem cells (ESC) or CRISPR / Cas9 gene editing in single - cell zygotes.

The goal of the International Mouse Phenotyping Consortium (IMPC) is to discover functional insight for every gene by generating and systematically phenotyping 20,000 knockout mouse strains.