Sentences with phrase «many normal cells»

But in the lab, when the scientists manipulated human cells to be able to create the water bear shielding protein — called Dsup — they showed about half the DNA damage as normal cells.

«You have to understand how normal cells work.»

Since PSMA's limited on normal cells, the therapy should hammer away at tumors while letting healthy tissues do their job.

There is evidence to suggest that cancer cells are softer than normal cells (although tumours are stiffer).

And a histogram of stiffness showed that as tumours become «pre-malignant», two peaks appear on the graph, rather than the single one observed for normal cells.

Manganese is an essential trace metal that is crucial for normal cell function and metabolism and is particularly important for brain health.

The oxidative damage caused to normal cells by free radicals has been linked to chronic conditions like cancer, heart disease, and degenerative diseases related to aging.

Sometimes there are some normal cells and sometimes all of the growth is abnormal, but unfortunately either way this is not a viable pregnancy.

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cells.

We reasoned that if the hypothesis was correct, we might be able to find the src gene (the oncogene of the Rous sarcoma virus) in the DNA of normal cells.

It will be of no use to invent means for impeding the activities responsible for cancerous growth if the same activities are also required for the survival of normal cells.

In one respect the first look is unnerving, because the chemical mechanisms that seem to drive the cancer cell astray are not different in kind from mechanisms at work in the normal cell.

Because they multiply quickly and spread throughout the body, cancer cells require more energy than normal cells.

According to Chan, neoantigens have two advantages: First, they look very foreign to the immune system and second, they don't appear in normal cells.

Working with human breast tissue, the new study's authors attempted to induce EMT in normal cells; they figured they would just get fibroblasts, a type of connective tissue that is important in wound healing.

When injected together, they killed up to 90 per cent of polyps and left normal cells unaffected.

To determine local immune control, where the invasive tissue interfaces with normal cells, post-birth placentas and stage - four melanoma tumors were examined.

The other significant finding of the study, says Garrett Jenkinson, Ph.D., assistant research scientist at the Johns Hopkins Whiting School of Engineering who carried out much of the analyses, was that this variability goes haywire in cancer cells, which may display significant regional differences in methylation stochasticity compared to normal cells.

The hope is that 3BP specifically kills certain cancer cells — while leaving normal cells alone — because they rely more on glucose metabolism than on an alternative pathway called oxidative phosphorylation.

The study found that carfilzomib and irinotecan have a potential synergistic effect in SCLC and other Irinotecan - sensitive cancers by allowing normal DNA damage repair and enabling normal cell - cycle death.

«Just as normal cells with the same genome differentiate into many different cell types, a single tumor characterized by specific genetic mutations can contain many different types of cells — stem - like and more differentiated cells — with the difference being rooted in their epigenetic information.

A 2009 study by the same researchers showed that NF - kB helps normal cells in DNA repair, which may prevent them from harming the body.

Today is the 70th birthday of Elizabeth Hay, an embryologist at Harvard Medical School who, through pioneering studies on regeneration of amphibian limbs, has shed light on the cellular mechanisms that transform normal cells into tumors.

Several mutations were found in genes coding the machinery that makes mitochondrial proteins, and so would probably hinder mitochondria's ability to make the chemical fuel called ATP, which is used by normal cells.

«Especially in early stages, normal cells can kill cancer cells,» says biologist Yasuyuki Fujita, who led the British team.

But the mutants actually lost out to the normal cells every time.

He and his group had been looking for evidence that normal cells in the cancer's environment contribute to chemotherapy resistance.

A Biophysical Journal study published September 1 reveals exactly how the venom's toxin — called MP1 (Polybia - MP1)-- selectively kills cancer cells without harming normal cells.

Cancer cells may produce unique metabolic profiles, in part because they grow very rapidly and have metabolic activity very different from normal cells.

«In this way, it will be possible to experimentally recapitulate the necessary subsequent steps for normal cells to transform into cancer cells.»

«As it has been shown to be selective to cancer cells and non-toxic to normal cells in the lab, this peptide has the potential to be safe, but further work would be required to prove that.»

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

Fat cells cultured from the body mass index of a morbidly obese patient cause multiple myeloma cells to anchor to a much greater extent than normal cells and produce a significantly larger number of blood vessels to sustain the cancer cells.

And because mouse embryo cells with inactivated copies of BRCA2 are more sensitive to ionizing radiation than normal cells are, «it's a reasonable extrapolation» that breast cancers with mutated copies of the gene may be especially good candidates for radiation therapy.

«The challenge is finding targets that exist on other types of cancer cells but not on normal cells,» says pediatric oncologist Stephan Grupp of the Children's Hospital of Philadelphia, who worked with Porter on testing the treatment in mice.

According to Eckmann, «The special thing about these processes is that they involve known molecules with very long evolutionary histories, previously receiving attention as suppressors of tumour formation within the context of normal cell division.

By measures of elasticity, normal cells were about twice as stiff as the mutated ones, which were basically soft.

Moreover, the team compared TiY with a known vimentin - inhibitor, withaferin A (WFA) and observed that TiY has a stronger selectivity towards TICs than WFA, when compared with toxicity to normal cells and non-TIC cells.

«T - DM1 delivers the DM1 agent directly to the tumour cell, while limiting exposure of DM1 to normal cells,» Hurvitz says.

How it hides: In a normal cell, genes encode instructions for surface proteins known as the major histocompatibility complex (MHC).

In abnormal [PSI +] cells, which are genetically identical to normal cells, the important protein clumps together, and the cells are unable to grow under certain conditions.

Since cancer cells divide more often than most normal cells, they react more sensitive to DNA damaging agents.

If a breast cancer line had silently contaminated Klonisch's cell culture early on, it would have been subject to the usual technique for immortalizing a normal cell (which involves applying enzymes, antibiotics and antibiotic - resistant genes).

Most of the time, let - 7 effectively communicated to the gene exactly how much KRAS protein was needed for normal cell turnover.

Test tube experiments showed that white blood cells with the mutation responded more strongly to Il - 4 than did normal cells.

Researchers know that, like normal cells, cancer cells start to die when the mercury rises above 43 ˚C.

Unlike normal cells, however, the tumour cells are considerably more sensitive, because they can not repair damage well.

«Blocking the damage response in normal cells that have been bathed in chemotherapy could be instrumental in keeping errant or dormant cancer cells from starting down the path to proliferation,» he said.

But among its detailed descriptions of cell preparation, discursive descriptions of the issues around abortion, and the story of the discovery that normal cells have a finite lifespan, there is plenty of ammunition for those arguing with family or Facebook friends who have swallowed the conspiracy theories of the anti-vaccination community.

«Tumor cells produce larger quantities of H2O2 and use oxidative signals at higher levels than normal cells in order to drive their own growth,» says Mirko Sobotta, first author of the publication.